Comparison of Sequential versus Concurrent Albumin and Furosemide in Pediatric Nephrotic Syndrome Patients: A Blinded Randomized Controlled Clinical Trial Article Swipe
Fatemeh Tadayoni
,
Bahador Mirrahimi
,
Hasti Charousae
,
Masoumeh Mohkam
,
Reza Dalirani
,
Seyyed Mohammad Tabatabaei
,
Nasrin Esfandiar
,
Zahra Pournasiri
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.5863/jppt-24-00026
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.5863/jppt-24-00026
OBJECTIVE Comparing the effectiveness of sequential and concurrent administration of albumin and furosemide in reducing edema in children with nephrotic syndrome. METHOD A double blinded randomized controlled clinical trial was conducted in patients diagnosed with nephrotic syndrome between 2 and 15 years of age. The patients were randomly divided into 2 groups of 32 subjects. One group received an admixture of albumin and furosemide, and the other received furosemide immediately after the albumin infusion. The weight loss and urinary sodium concentration results were analyzed in each group. RESULTS The comparison of the 2 groups demonstrated that the group that received albumin and furosemide sequentially had statistically significant weight loss. There was no significant difference in the amount of urinary sodium, as determined by random spot urine analysis in 9 subjects in each group, and no study drug-associated adverse effects were observed in any patient. CONCLUSIONS there was a significant difference between weight loss in the 2 groups that received albumin and furosemide simultaneously or sequentially and according to this study, the sequential method of furosemide administration after albumin infusion is the preferred method to reduce edema in pediatric patients with nephrotic syndrome.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.5863/jppt-24-00026
- OA Status
- green
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411468988
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411468988Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.5863/jppt-24-00026Digital Object Identifier
- Title
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Comparison of Sequential versus Concurrent Albumin and Furosemide in Pediatric Nephrotic Syndrome Patients: A Blinded Randomized Controlled Clinical TrialWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-06-01Full publication date if available
- Authors
-
Fatemeh Tadayoni, Bahador Mirrahimi, Hasti Charousae, Masoumeh Mohkam, Reza Dalirani, Seyyed Mohammad Tabatabaei, Nasrin Esfandiar, Zahra PournasiriList of authors in order
- Landing page
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https://doi.org/10.5863/jppt-24-00026Publisher landing page
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/12172666Direct OA link when available
- Concepts
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Furosemide, Medicine, Nephrotic syndrome, Albumin, Randomized controlled trial, Internal medicine, Double blinded, Clinical trial, Pathology, Placebo, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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56Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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