Comparison of tetrabenazine, tiapride and olanzapine in Huntington's disease: a one-year French randomized multicenter study (Neuro-HD) Article Swipe

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Katia Youssov , Étienne Audureau , Jérémie Pariente , Jean‐Philippe Azulay , Isabelle Bénatru , Alexandra Dürr , Pierre Krystkowiak , Cécilia Marelli , Christine Tranchant , C. Simonin , Christophe Verny , Anne‐Catherine Bachoud‐Lévi , Mélissa Tir , Clarisse Scherer , Adriana Prundean , Philippe Allain , Tiffany Monier , Laurie Lemoine , Aimée Petit , Perrine Charles , Élodie Petit , Frédérique Fluchère , Éric Decorte , Marie Delliaux , Arnaud Delval , S. Ansquer , Emilie Rabois , Anaïs Fradet , Anziza Manssouri , Jean Luc Houeto ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.1016/j.parkreldis.2025.108017

Olanzapine improved chorea, behavior, and irritability, although with a slight increase in rigidity. Tetrabenazine confirmed efficacy for chorea but was associated with mood disorders and drowsiness, while tiapride reduced irritability. These results underscore the importance of symptom-specific, individualized treatment.

Related Topics

Randomized Controlled Trial

Disease

Dopamine

Concepts

Tetrabenazine Tiapride Olanzapine Huntington's disease Medicine Chorea Multicenter study Psychiatry Internal medicine Pharmacology Randomized controlled trial Disease Schizophrenia (object-oriented programming) Dopamine

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Type: article
Language: en
Landing Page: https://doi.org/10.1016/j.parkreldis.2025.108017
PDF: https://www.prd-journal.com/article/S1353-8020(25)00758-8/pdf
OA Status: hybrid
References: 35
Related Works: 10
OpenAlex ID: https://openalex.org/W4413959989

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OpenAlex ID: https://openalex.org/W4413959989

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DOI: https://doi.org/10.1016/j.parkreldis.2025.108017

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Title: Comparison of tetrabenazine, tiapride and olanzapine in Huntington's disease: a one-year French randomized multicenter study (Neuro-HD)

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Type: article

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Language: en

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Publication year: 2025

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Publication date: 2025-09-03

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Authors: Katia Youssov, Étienne Audureau, Jérémie Pariente, Jean‐Philippe Azulay, Isabelle Bénatru, Alexandra Dürr, Pierre Krystkowiak, Cécilia Marelli, Christine Tranchant, C. Simonin, Christophe Verny, Anne‐Catherine Bachoud‐Lévi, Mélissa Tir, Clarisse Scherer, Adriana Prundean, Philippe Allain, Tiffany Monier, Laurie Lemoine, Aimée Petit, Perrine Charles, Élodie Petit, Frédérique Fluchère, Éric Decorte, Marie Delliaux, Arnaud Delval, S. Ansquer, Emilie Rabois, Anaïs Fradet, Anziza Manssouri, Jean Luc Houeto

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Landing page: https://doi.org/10.1016/j.parkreldis.2025.108017

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PDF URL: https://www.prd-journal.com/article/S1353-8020(25)00758-8/pdf

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OA URL: https://www.prd-journal.com/article/S1353-8020(25)00758-8/pdf

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Concepts: Tetrabenazine, Tiapride, Olanzapine, Huntington's disease, Medicine, Chorea, Multicenter study, Psychiatry, Internal medicine, Pharmacology, Randomized controlled trial, Disease, Schizophrenia (object-oriented programming), Dopamine

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References (count): 35

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