Comparison of the Effect of Pan-Retinal Photocoagulation versus Intravitreal Anti-vascular Endothelial Growth Factor Injection on the Foveal Vasculature Using Optical Coherence Tomography Angiography Article Swipe
Hamid Riazi‐Esfahani
,
Amin Ahmadi
,
Reza Sadeghi
,
Masoud Mirghorbani
,
Fariba Ghassemi
,
Mohammad Zarei
,
Hassan Khojasteh
,
Hooshang Faghihi
,
Elias Khalili Pour
,
Ahmad Mirshahi
,
Nikoo Bayan
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2159623/v1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2159623/v1
Introduction: To evaluate and compare macular vasculature changes in 1 and 3-months after initiating treatment with either panretinal photocoagulation (PRP) or Intravitreal bevacizumab (IVB) injection. Methods : A total of 62 eyes from 33 diabetic patients without macular edema were included in this prospective case series. Of these, thirty-nine eyes (21 patients) were allocated to the PRP group, while 23 eyes (12 patients) were treated with IVB biosimilar (Stivant â ). Optical tomography angiography (OCTA) was performed to measure foveal avascular zone (FAZ) characteristics as well as superficial (SCP) and deep vascular plexus (DCP) densities. Results : After the initiation of IVB injections, the FAZ area and Perimeter expanded modestly at month 1 but returned to baseline level after three months. In the PRP group, however, FAZ area and Perimeter were rather steady. FAZ area changes were significantly different between treatment groups at month 1 (p=0.02), but not at month 3 (p=0.31). The comparison of two groups based on mean FAZ perimeter change revealed a significant difference at month 1, but no significant difference at month 3 (p=0.03 and p=0.48, respectively). There was no significant difference in the FAZ circularity index change between the two groups at each timepoints (p=0.55 and p=0.31). The foveal vessel density changes in the SCP were not statistically significant between the two groups, at both month 1 and 3 (all P>0.05). A comparison of two treatment arms based on mean DCP density change revealed a significant difference at month 1, but not at month 3 (p=0.01 and p=0.49, respectively). Conclusion : Some vascular metrics changes in OCTA (e.g., FAZ area, Perim, Foveal DCP vascular density) may be significantly different between two types of therapies in the very early short-term (1 month) after treatment initiation. In the third month following treatment, all of these differences diminished to insignificance.
Related Topics
Concepts
Medicine
Perimeter
Ophthalmology
Ranibizumab
Optical coherence tomography angiography
Significant difference
Retinal
Panretinal photocoagulation
Macular edema
Optical coherence tomography
Foveal
Foveal avascular zone
Edema
Diabetic retinopathy
Bevacizumab
Surgery
Internal medicine
Diabetes mellitus
Chemotherapy
Endocrinology
Geometry
Mathematics
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-2159623/v1
- https://www.researchsquare.com/article/rs-2159623/latest.pdf
- OA Status
- green
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4306740430
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4306740430Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-2159623/v1Digital Object Identifier
- Title
-
Comparison of the Effect of Pan-Retinal Photocoagulation versus Intravitreal Anti-vascular Endothelial Growth Factor Injection on the Foveal Vasculature Using Optical Coherence Tomography AngiographyWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-10-18Full publication date if available
- Authors
-
Hamid Riazi‐Esfahani, Amin Ahmadi, Reza Sadeghi, Masoud Mirghorbani, Fariba Ghassemi, Mohammad Zarei, Hassan Khojasteh, Hooshang Faghihi, Elias Khalili Pour, Ahmad Mirshahi, Nikoo BayanList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-2159623/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-2159623/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-2159623/latest.pdfDirect OA link when available
- Concepts
-
Medicine, Perimeter, Ophthalmology, Ranibizumab, Optical coherence tomography angiography, Significant difference, Retinal, Panretinal photocoagulation, Macular edema, Optical coherence tomography, Foveal, Foveal avascular zone, Edema, Diabetic retinopathy, Bevacizumab, Surgery, Internal medicine, Diabetes mellitus, Chemotherapy, Endocrinology, Geometry, MathematicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
30Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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