Comparison of the Effects of Tamarind Seed Extract (Tamarindus Indica L.) with Sertraline in Treating Premature Ejaculation: A Randomized Double-blind Trial Article Swipe
Ali Sahraian
,
Iman Shamohammadi
,
Somayeh Daneshvar
,
Payam Sadeghi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.31661/gmj.v14i.4015
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.31661/gmj.v14i.4015
Background: Premature ejaculation (PE) is a prevalent male sexual disorder often untreated due to embarrassment. This study compares the efficacy of tamarind seed extract (Tamarindus indica L.) with sertraline in treating PE. Materials and Methods: In this randomized, double-blind, parallel-group trial, 41 men diagnosed with PE at urology and psychiatric clinics in Shiraz, Iran (2023) were enrolled. Participants were randomly assigned to receive either 80 mg tamarind seed extract capsules (Group A, n=20) or 50 mg sertraline tablets (Group B, n=21) daily for 4 weeks. The primary outcome was the Premature Ejaculation Diagnostic Tool (PEDT) score, with secondary outcomes including International Index of Erectile Function (IIEF) scores (erectile function, orgasmic function, sexual desire, intercourse satisfaction, overall satisfaction) and side effects. Data were analyzed using SPSS version 22 with t-tests and ANOVA (P<0.05). Results: Both treatments significantly improved PEDT scores (P=0.001, η_p^2=0.76, 95% CI for mean difference: [-6.95, -4.95]) and IIEF subscales (P<0.01). No significant differences were observed between groups (P=0.69, η_p^2=0.10) or in the time-group interaction (P=0.42, η_p^2=0.15). Side effects were minimal in both groups.Conclusion: The findings indicate a potential relationship between tamarind seed extract and improvements in premature ejaculation and related factors, comparable to sertraline; however, these results should be interpreted with caution and require further validation through additional research.Trial registration number: IRCT20140926019295N4.
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Metadata
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- Language
- en
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- https://doi.org/10.31661/gmj.v14i.4015
- OA Status
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- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4413977768Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.31661/gmj.v14i.4015Digital Object Identifier
- Title
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Comparison of the Effects of Tamarind Seed Extract (Tamarindus Indica L.) with Sertraline in Treating Premature Ejaculation: A Randomized Double-blind TrialWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-08-27Full publication date if available
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Ali Sahraian, Iman Shamohammadi, Somayeh Daneshvar, Payam SadeghiList of authors in order
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https://doi.org/10.31661/gmj.v14i.4015Publisher landing page
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.31661/gmj.v14i.4015Direct OA link when available
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Premature ejaculation, Medicine, Sertraline, Traditional medicine, Double blind, Alternative medicine, Psychiatry, Placebo, Antidepressant, Anxiety, Psychoanalysis, Pathology, PsychologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.satisfaction, | 114 |
| abstract_inverted_index.significantly | 135 |
| abstract_inverted_index.η_p^2=0.15). | 167 |
| abstract_inverted_index.embarrassment. | 14 |
| abstract_inverted_index.parallel-group | 39 |
| abstract_inverted_index.research.Trial | 210 |
| abstract_inverted_index.groups.Conclusion: | 174 |
| abstract_inverted_index.IRCT20140926019295N4. | 213 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 4 |
| citation_normalized_percentile.value | 0.46186784 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |