Comparison of the Micronaut-AM System and the EUCAST Broth Microdilution Reference Method for MIC Determination of Four Antifungals against Aspergillus fumigatus Article Swipe
Nikolett Gyurtane Szabo
,
Valentin Joste
,
Sandrine Houzé
,
Éric Dannaoui
,
Christine Bonnal
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/jof9070721
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/jof9070721
The Antifungal Susceptibility Testing method of the European Committee on Antimicrobial Susceptibility Testing (EUCAST-AFST) is a reference technique for the determination of the Minimum Inhibitory Concentration (MIC) of antifungals for Aspergillus fumigatus. However, it is time-consuming and requires expertise. Micronaut-AM (M-AM) is a fast, simple, time-saving, and ready-to-use new colorimetric method using an indicator (resazurin) to facilitate the visual reading. The aim of this retrospective study was to evaluate the performance of the M-AM system and compare it with the EUCAST broth microdilution reference method to determine the susceptibility of 77 A. fumigatus clinical strains to amphotericin B, itraconazole, voriconazole, and posaconazole. Overall, the essential agreements within ±2 dilutions were 100%, 62%, 58%, and 30% and the categorical agreements were 100%, 97%, 91%, and 87% for amphotericin B, itraconazole, voriconazole, and posaconazole, respectively. No categorical discrepancy was found for amphotericin B, but several categorical discordances were observed with azole antifungals. However, only 2 of the 16 azole-resistant strains confirmed by the cyp51A sequencing would have been misclassified by M-AM. The use of M-AM is probably suitable for the determination of the MICs of amphotericin B, but further evaluations are needed to confirm its usefulness for the determination of the MICs of azoles for A. fumigatus.
Related Topics
Concepts
Posaconazole
Itraconazole
Aspergillus fumigatus
Voriconazole
Broth microdilution
Amphotericin B
Microbiology
Minimum inhibitory concentration
Azole
Biology
Antifungal
Antimicrobial
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jof9070721
- https://www.mdpi.com/2309-608X/9/7/721/pdf?version=1688351195
- OA Status
- gold
- Cited By
- 3
- References
- 20
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4382983250
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4382983250Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jof9070721Digital Object Identifier
- Title
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Comparison of the Micronaut-AM System and the EUCAST Broth Microdilution Reference Method for MIC Determination of Four Antifungals against Aspergillus fumigatusWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-06-30Full publication date if available
- Authors
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Nikolett Gyurtane Szabo, Valentin Joste, Sandrine Houzé, Éric Dannaoui, Christine BonnalList of authors in order
- Landing page
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https://doi.org/10.3390/jof9070721Publisher landing page
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https://www.mdpi.com/2309-608X/9/7/721/pdf?version=1688351195Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2309-608X/9/7/721/pdf?version=1688351195Direct OA link when available
- Concepts
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Posaconazole, Itraconazole, Aspergillus fumigatus, Voriconazole, Broth microdilution, Amphotericin B, Microbiology, Minimum inhibitory concentration, Azole, Biology, Antifungal, AntimicrobialTop concepts (fields/topics) attached by OpenAlex
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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20Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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