Comparison of the therapeutic methods (pharmacologic and nonpharmacologic) on prevention of post-ERCP pancreatitis: A systematic review and meta-analysis Article Swipe
Masood Shirmohammadi
,
Mohammad Hossein Somi
,
Morteza Ghojazadeh
,
Hossein Hosseinfard
,
Tahmasebi Fatemeh
,
Elham Sheykhsaran
,
Amin Sadrazar
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.34172/jrcm.2021.017
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.34172/jrcm.2021.017
Background: Pancreatitis is considered as the most prevalent serious disorders of endoscopic retrograde cholangiopancreatography (ERCP). Different approaches have been suggested to prevent or reduce this complication. Therefore we aim to investigate them in the current study. This systematic review was performed in 2019 using Pubmed, Embase, google scholar and Cochrane library. Two reviewers selected eligible studies and outcomes of interest were extracted. Meta-analysis was done by using the random or fixed-effect models. I-square statistic test was used for heterogeneity analysis. Material and Methods: Totally, 2758 articles were searched. Thereafter duplicated and irrelevant articles were excluded, and six articles were entered to the present study. Six RCTs were considered eligible with a total participants of 1685. Results: The relative risk of PEP was not significantly different in NSAID and hydration groups (Pooled RR=1.19, 95%CI: 0.40 to 3.50, P-value=0.74). The random effect model indicated no significant differences between NSAID and NSAID+hydration groups regarding the incidence of PEP (Pooled RR=2.19, 95%CI: 0.70 to 6.88, P-value=0.17). Conclusion: Additionally, the results of one study showed that rectal indomethacin alone appeared to be more effective for preventing PEP than no prophylaxis, PSP alone, and the combination of indomethacin and PSP. Using NSAIDs alone or the combination of NSAIDs and hydration can reduce the risk of post-ERCP pancreatitis. Lack of studies comparing different approaches of prophylaxis in post-ERCP patient or the reporting of different parameters among the existing studies seriously limited the possibility and quality of meta-analysis. Further well-designed studies with accurate reporting of data is necessary to provide more reliable conclusion.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.34172/jrcm.2021.017
- https://jrcm.tbzmed.ac.ir/PDF/jrcm-9-17.pdf
- OA Status
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- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3158276788
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3158276788Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.34172/jrcm.2021.017Digital Object Identifier
- Title
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Comparison of the therapeutic methods (pharmacologic and nonpharmacologic) on prevention of post-ERCP pancreatitis: A systematic review and meta-analysisWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-04-25Full publication date if available
- Authors
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Masood Shirmohammadi, Mohammad Hossein Somi, Morteza Ghojazadeh, Hossein Hosseinfard, Tahmasebi Fatemeh, Elham Sheykhsaran, Amin SadrazarList of authors in order
- Landing page
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https://doi.org/10.34172/jrcm.2021.017Publisher landing page
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https://jrcm.tbzmed.ac.ir/PDF/jrcm-9-17.pdfDirect link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://jrcm.tbzmed.ac.ir/PDF/jrcm-9-17.pdfDirect OA link when available
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Medicine, Meta-analysis, Cochrane Library, Pancreatitis, Endoscopic retrograde cholangiopancreatography, Relative risk, Internal medicine, Random effects model, Incidence (geometry), Confidence interval, Physics, OpticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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48Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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