Comparison of topical and intravenous tranexamic acid for reducing postoperative blood loss in single-level posterior lumbar interbody fusion: a retrospective study from Japan Article Swipe
Kazuma Kitaguchi
,
Kunihiko Hashimoto
,
Takashi Kaito
,
Kazuya Oshima
,
Eiji Wada
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.31616/asj.2024.0463
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.31616/asj.2024.0463
Study Design: A retrospective cohort study.Purpose: This study aimed to compare the efficacy and safety of topical and relatively high-dose intravenous tranexamic acid (TXA) in minimizing postoperative blood loss in patients undergoing single-level posterior lumbar interbody fusion (PLIF).Overview of Literature: Topical TXA demonstrates a similar hemostatic efficacy to intravenous TXA. However, whether intravenous or topical TXA is more effective in minimizing postoperative bleeding in spine surgery remains unclear.Methods: In total, 140 patients who underwent single-level PLIF were retrospectively enrolled and assigned to the (1) control group (n=58), which did not receive TXA; (2) TXA (iv) group (n=39), which was administered intravenously with a relatively high-dose (2 g) of TXA immediately before wound closure; and (3) TXA (t) group (n=43), which received topical application of TXA (1 g in 100 mL of saline solution) to the wound immediately before wound closure.Results: No significant differences in age, body mass index, sex, preoperative hematological parameters, or intraoperative blood loss were found among the three groups. The total postoperative blood loss was significantly lower in the TXA (t) group than in the TXA (iv) and control groups (389.6±137.5 vs. 543.6±175.4 vs. 700.3±231.4, respectively; both p<0.01). Analysis of blood loss over time revealed significantly less blood loss throughout the postoperative period in the TXA (t) group than in the control group (p<0.01). In contrast, the TXA (iv) group showed less blood loss than the control group in 2–6 hours and 6–12 hours postoperatively (p<0.05). No complications, such as thromboembolic events, were associated with the use of either TXA formulation.Conclusions: Following single-level PLIF, topical TXA exerts rapid and long-lasting effects on minimizing postoperative blood loss compared with twice the amount of intravenous TXA.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.31616/asj.2024.0463
- https://www.asianspinejournal.org/upload/pdf/asj-2024-0463.pdf
- OA Status
- diamond
- Cited By
- 1
- References
- 20
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411573734
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4411573734Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.31616/asj.2024.0463Digital Object Identifier
- Title
-
Comparison of topical and intravenous tranexamic acid for reducing postoperative blood loss in single-level posterior lumbar interbody fusion: a retrospective study from JapanWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-06-24Full publication date if available
- Authors
-
Kazuma Kitaguchi, Kunihiko Hashimoto, Takashi Kaito, Kazuya Oshima, Eiji WadaList of authors in order
- Landing page
-
https://doi.org/10.31616/asj.2024.0463Publisher landing page
- PDF URL
-
https://www.asianspinejournal.org/upload/pdf/asj-2024-0463.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.asianspinejournal.org/upload/pdf/asj-2024-0463.pdfDirect OA link when available
- Concepts
-
Medicine, Tranexamic acid, Blood loss, Anesthesia, Retrospective cohort study, Surgery, Saline, LumbarTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
20Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4411573734 |
|---|---|
| doi | https://doi.org/10.31616/asj.2024.0463 |
| ids.doi | https://doi.org/10.31616/asj.2024.0463 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40551468 |
| ids.openalex | https://openalex.org/W4411573734 |
| fwci | 4.98816334 |
| type | article |
| title | Comparison of topical and intravenous tranexamic acid for reducing postoperative blood loss in single-level posterior lumbar interbody fusion: a retrospective study from Japan |
| biblio.issue | 4 |
| biblio.volume | 19 |
| biblio.last_page | 560 |
| biblio.first_page | 553 |
| topics[0].id | https://openalex.org/T12548 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9990000128746033 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2720 |
| topics[0].subfield.display_name | Hematology |
| topics[0].display_name | Hemostasis and retained surgical items |
| topics[1].id | https://openalex.org/T10693 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9984999895095825 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2704 |
| topics[1].subfield.display_name | Biochemistry |
| topics[1].display_name | Blood transfusion and management |
| topics[2].id | https://openalex.org/T10746 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9980000257492065 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2720 |
| topics[2].subfield.display_name | Hematology |
| topics[2].display_name | Platelet Disorders and Treatments |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.9820997714996338 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2779637338 |
| concepts[1].level | 3 |
| concepts[1].score | 0.9446433782577515 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q418666 |
| concepts[1].display_name | Tranexamic acid |
| concepts[2].id | https://openalex.org/C2991743468 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6313539147377014 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q166019 |
| concepts[2].display_name | Blood loss |
| concepts[3].id | https://openalex.org/C42219234 |
| concepts[3].level | 1 |
| concepts[3].score | 0.600732684135437 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q131130 |
| concepts[3].display_name | Anesthesia |
| concepts[4].id | https://openalex.org/C167135981 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5568994879722595 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2146302 |
| concepts[4].display_name | Retrospective cohort study |
| concepts[5].id | https://openalex.org/C141071460 |
| concepts[5].level | 1 |
| concepts[5].score | 0.5554759502410889 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q40821 |
| concepts[5].display_name | Surgery |
| concepts[6].id | https://openalex.org/C2777397205 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4803558588027954 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q275792 |
| concepts[6].display_name | Saline |
| concepts[7].id | https://openalex.org/C44575665 |
| concepts[7].level | 2 |
| concepts[7].score | 0.44801822304725647 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q1293405 |
| concepts[7].display_name | Lumbar |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.9820997714996338 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/tranexamic-acid |
| keywords[1].score | 0.9446433782577515 |
| keywords[1].display_name | Tranexamic acid |
| keywords[2].id | https://openalex.org/keywords/blood-loss |
| keywords[2].score | 0.6313539147377014 |
| keywords[2].display_name | Blood loss |
| keywords[3].id | https://openalex.org/keywords/anesthesia |
| keywords[3].score | 0.600732684135437 |
| keywords[3].display_name | Anesthesia |
| keywords[4].id | https://openalex.org/keywords/retrospective-cohort-study |
| keywords[4].score | 0.5568994879722595 |
| keywords[4].display_name | Retrospective cohort study |
| keywords[5].id | https://openalex.org/keywords/surgery |
| keywords[5].score | 0.5554759502410889 |
| keywords[5].display_name | Surgery |
| keywords[6].id | https://openalex.org/keywords/saline |
| keywords[6].score | 0.4803558588027954 |
| keywords[6].display_name | Saline |
| keywords[7].id | https://openalex.org/keywords/lumbar |
| keywords[7].score | 0.44801822304725647 |
| keywords[7].display_name | Lumbar |
| language | en |
| locations[0].id | doi:10.31616/asj.2024.0463 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S11653694 |
| locations[0].source.issn | 1976-1902, 1976-7846 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1976-1902 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Asian Spine Journal |
| locations[0].source.host_organization | https://openalex.org/P4310319473 |
| locations[0].source.host_organization_name | Korean Spine Society |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319473 |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | https://www.asianspinejournal.org/upload/pdf/asj-2024-0463.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Asian Spine Journal |
| locations[0].landing_page_url | https://doi.org/10.31616/asj.2024.0463 |
| locations[1].id | pmid:40551468 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Asian spine journal |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40551468 |
| locations[2].id | pmh:oai:europepmc.org:11210589 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12400090 |
| locations[3].id | pmh:oai:doaj.org/article:7bd895bc63fe4946897657e366ebc5a4 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Asian Spine Journal, Vol 19, Iss 4, Pp 553-560 (2025) |
| locations[3].landing_page_url | https://doaj.org/article/7bd895bc63fe4946897657e366ebc5a4 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5032618920 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-2483-087X |
| authorships[0].author.display_name | Kazuma Kitaguchi |
| authorships[0].countries | JP |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210108563 |
| authorships[0].affiliations[0].raw_affiliation_string | Spine and Spinal Cord Center, Osaka Police Hospital, Osaka, Japan. |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I4210117281 |
| authorships[0].affiliations[1].raw_affiliation_string | Spine and Spinal Cord Center, General Incorporated Foundation Sumitomo Hospital, Osaka, Japan. |
| authorships[0].institutions[0].id | https://openalex.org/I4210108563 |
| authorships[0].institutions[0].ror | https://ror.org/015x7ap02 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210108563 |
| authorships[0].institutions[0].country_code | JP |
| authorships[0].institutions[0].display_name | Osaka Police Hospital |
| authorships[0].institutions[1].id | https://openalex.org/I4210117281 |
| authorships[0].institutions[1].ror | https://ror.org/02m9ewz37 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I4210117281 |
| authorships[0].institutions[1].country_code | JP |
| authorships[0].institutions[1].display_name | Sumitomo Hospital |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Kazuma Kitaguchi |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Spine and Spinal Cord Center, General Incorporated Foundation Sumitomo Hospital, Osaka, Japan., Spine and Spinal Cord Center, Osaka Police Hospital, Osaka, Japan. |
| authorships[1].author.id | https://openalex.org/A5032131242 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-3156-8419 |
| authorships[1].author.display_name | Kunihiko Hashimoto |
| authorships[1].countries | JP |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210108563 |
| authorships[1].affiliations[0].raw_affiliation_string | Spine and Spinal Cord Center, Osaka Police Hospital, Osaka, Japan. |
| authorships[1].institutions[0].id | https://openalex.org/I4210108563 |
| authorships[1].institutions[0].ror | https://ror.org/015x7ap02 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210108563 |
| authorships[1].institutions[0].country_code | JP |
| authorships[1].institutions[0].display_name | Osaka Police Hospital |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Kunihiko Hashimoto |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Spine and Spinal Cord Center, Osaka Police Hospital, Osaka, Japan. |
| authorships[2].author.id | https://openalex.org/A5001669387 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-4882-2997 |
| authorships[2].author.display_name | Takashi Kaito |
| authorships[2].countries | JP |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210112889 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Orthopaedic Surgery, Osaka Rosai Hospital, Osaka, Japan. |
| authorships[2].institutions[0].id | https://openalex.org/I4210112889 |
| authorships[2].institutions[0].ror | https://ror.org/02bj40x52 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210112889 |
| authorships[2].institutions[0].country_code | JP |
| authorships[2].institutions[0].display_name | Osaka Rosai Hospital |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Takashi Kaito |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Orthopaedic Surgery, Osaka Rosai Hospital, Osaka, Japan. |
| authorships[3].author.id | https://openalex.org/A5055902695 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-4618-9326 |
| authorships[3].author.display_name | Kazuya Oshima |
| authorships[3].countries | JP |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210108563 |
| authorships[3].affiliations[0].raw_affiliation_string | Spine and Spinal Cord Center, Osaka Police Hospital, Osaka, Japan. |
| authorships[3].institutions[0].id | https://openalex.org/I4210108563 |
| authorships[3].institutions[0].ror | https://ror.org/015x7ap02 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210108563 |
| authorships[3].institutions[0].country_code | JP |
| authorships[3].institutions[0].display_name | Osaka Police Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Kazuya Oshima |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Spine and Spinal Cord Center, Osaka Police Hospital, Osaka, Japan. |
| authorships[4].author.id | https://openalex.org/A5103233341 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-2876-645X |
| authorships[4].author.display_name | Eiji Wada |
| authorships[4].countries | JP |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210108563 |
| authorships[4].affiliations[0].raw_affiliation_string | Spine and Spinal Cord Center, Osaka Police Hospital, Osaka, Japan. |
| authorships[4].institutions[0].id | https://openalex.org/I4210108563 |
| authorships[4].institutions[0].ror | https://ror.org/015x7ap02 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210108563 |
| authorships[4].institutions[0].country_code | JP |
| authorships[4].institutions[0].display_name | Osaka Police Hospital |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Eiji Wada |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Spine and Spinal Cord Center, Osaka Police Hospital, Osaka, Japan. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.asianspinejournal.org/upload/pdf/asj-2024-0463.pdf |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Comparison of topical and intravenous tranexamic acid for reducing postoperative blood loss in single-level posterior lumbar interbody fusion: a retrospective study from Japan |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12548 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9990000128746033 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2720 |
| primary_topic.subfield.display_name | Hematology |
| primary_topic.display_name | Hemostasis and retained surgical items |
| related_works | https://openalex.org/W4396964437, https://openalex.org/W3035954995, https://openalex.org/W4205595336, https://openalex.org/W3039445813, https://openalex.org/W4313436372, https://openalex.org/W4379158075, https://openalex.org/W3020890423, https://openalex.org/W2596754316, https://openalex.org/W2507821040, https://openalex.org/W1897449427 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.31616/asj.2024.0463 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S11653694 |
| best_oa_location.source.issn | 1976-1902, 1976-7846 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1976-1902 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Asian Spine Journal |
| best_oa_location.source.host_organization | https://openalex.org/P4310319473 |
| best_oa_location.source.host_organization_name | Korean Spine Society |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319473 |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | https://www.asianspinejournal.org/upload/pdf/asj-2024-0463.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Asian Spine Journal |
| best_oa_location.landing_page_url | https://doi.org/10.31616/asj.2024.0463 |
| primary_location.id | doi:10.31616/asj.2024.0463 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S11653694 |
| primary_location.source.issn | 1976-1902, 1976-7846 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1976-1902 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Asian Spine Journal |
| primary_location.source.host_organization | https://openalex.org/P4310319473 |
| primary_location.source.host_organization_name | Korean Spine Society |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319473 |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | https://www.asianspinejournal.org/upload/pdf/asj-2024-0463.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Asian Spine Journal |
| primary_location.landing_page_url | https://doi.org/10.31616/asj.2024.0463 |
| publication_date | 2025-06-24 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2138508459, https://openalex.org/W2556293386, https://openalex.org/W2144118031, https://openalex.org/W1983338441, https://openalex.org/W2106337515, https://openalex.org/W2296636069, https://openalex.org/W4313731548, https://openalex.org/W3208814134, https://openalex.org/W2800515141, https://openalex.org/W2790144951, https://openalex.org/W1989448583, https://openalex.org/W2121960517, https://openalex.org/W3009696193, https://openalex.org/W2990147497, https://openalex.org/W3075480405, https://openalex.org/W2960300380, https://openalex.org/W2995099656, https://openalex.org/W3013058801, https://openalex.org/W2023233821, https://openalex.org/W50135966 |
| referenced_works_count | 20 |
| abstract_inverted_index.A | 2 |
| abstract_inverted_index.a | 43, 102 |
| abstract_inverted_index.g | 126 |
| abstract_inverted_index.(1 | 125 |
| abstract_inverted_index.(2 | 105 |
| abstract_inverted_index.In | 68, 217 |
| abstract_inverted_index.No | 140, 239 |
| abstract_inverted_index.as | 242 |
| abstract_inverted_index.g) | 106 |
| abstract_inverted_index.in | 24, 29, 59, 63, 127, 143, 170, 176, 206, 212, 231 |
| abstract_inverted_index.is | 56 |
| abstract_inverted_index.mL | 129 |
| abstract_inverted_index.of | 15, 38, 107, 123, 130, 192, 250, 274 |
| abstract_inverted_index.on | 264 |
| abstract_inverted_index.or | 53, 152 |
| abstract_inverted_index.to | 9, 47, 81, 133 |
| abstract_inverted_index.(1) | 83 |
| abstract_inverted_index.(2) | 92 |
| abstract_inverted_index.(3) | 114 |
| abstract_inverted_index.(t) | 116, 173, 209 |
| abstract_inverted_index.100 | 128 |
| abstract_inverted_index.140 | 70 |
| abstract_inverted_index.TXA | 41, 55, 93, 108, 115, 124, 172, 178, 208, 220, 252, 258 |
| abstract_inverted_index.The | 162 |
| abstract_inverted_index.and | 13, 17, 79, 113, 180, 234, 261 |
| abstract_inverted_index.did | 88 |
| abstract_inverted_index.not | 89 |
| abstract_inverted_index.the | 11, 82, 134, 159, 171, 177, 203, 207, 213, 219, 228, 248, 272 |
| abstract_inverted_index.use | 249 |
| abstract_inverted_index.vs. | 184, 186 |
| abstract_inverted_index.was | 98, 167 |
| abstract_inverted_index.who | 72 |
| abstract_inverted_index.(iv) | 94, 179, 221 |
| abstract_inverted_index.PLIF | 75 |
| abstract_inverted_index.TXA. | 49, 276 |
| abstract_inverted_index.TXA; | 91 |
| abstract_inverted_index.This | 6 |
| abstract_inverted_index.acid | 22 |
| abstract_inverted_index.age, | 144 |
| abstract_inverted_index.body | 145 |
| abstract_inverted_index.both | 189 |
| abstract_inverted_index.less | 199, 224 |
| abstract_inverted_index.loss | 28, 155, 166, 194, 201, 226, 268 |
| abstract_inverted_index.mass | 146 |
| abstract_inverted_index.more | 57 |
| abstract_inverted_index.over | 195 |
| abstract_inverted_index.sex, | 148 |
| abstract_inverted_index.such | 241 |
| abstract_inverted_index.than | 175, 211, 227 |
| abstract_inverted_index.time | 196 |
| abstract_inverted_index.were | 76, 156, 245 |
| abstract_inverted_index.with | 101, 247, 270 |
| abstract_inverted_index.(TXA) | 23 |
| abstract_inverted_index.2–6 | 232 |
| abstract_inverted_index.PLIF, | 256 |
| abstract_inverted_index.Study | 0 |
| abstract_inverted_index.aimed | 8 |
| abstract_inverted_index.among | 158 |
| abstract_inverted_index.blood | 27, 154, 165, 193, 200, 225, 267 |
| abstract_inverted_index.found | 157 |
| abstract_inverted_index.group | 85, 95, 117, 174, 210, 215, 222, 230 |
| abstract_inverted_index.hours | 233, 236 |
| abstract_inverted_index.lower | 169 |
| abstract_inverted_index.rapid | 260 |
| abstract_inverted_index.spine | 64 |
| abstract_inverted_index.study | 7 |
| abstract_inverted_index.three | 160 |
| abstract_inverted_index.total | 163 |
| abstract_inverted_index.twice | 271 |
| abstract_inverted_index.which | 87, 97, 119 |
| abstract_inverted_index.wound | 111, 135, 138 |
| abstract_inverted_index.6–12 | 235 |
| abstract_inverted_index.amount | 273 |
| abstract_inverted_index.before | 110, 137 |
| abstract_inverted_index.cohort | 4 |
| abstract_inverted_index.either | 251 |
| abstract_inverted_index.exerts | 259 |
| abstract_inverted_index.fusion | 36 |
| abstract_inverted_index.groups | 182 |
| abstract_inverted_index.index, | 147 |
| abstract_inverted_index.lumbar | 34 |
| abstract_inverted_index.period | 205 |
| abstract_inverted_index.safety | 14 |
| abstract_inverted_index.saline | 131 |
| abstract_inverted_index.showed | 223 |
| abstract_inverted_index.total, | 69 |
| abstract_inverted_index.(n=39), | 96 |
| abstract_inverted_index.(n=43), | 118 |
| abstract_inverted_index.(n=58), | 86 |
| abstract_inverted_index.Design: | 1 |
| abstract_inverted_index.Topical | 40 |
| abstract_inverted_index.compare | 10 |
| abstract_inverted_index.control | 84, 181, 214, 229 |
| abstract_inverted_index.effects | 263 |
| abstract_inverted_index.events, | 244 |
| abstract_inverted_index.groups. | 161 |
| abstract_inverted_index.receive | 90 |
| abstract_inverted_index.remains | 66 |
| abstract_inverted_index.similar | 44 |
| abstract_inverted_index.surgery | 65 |
| abstract_inverted_index.topical | 16, 54, 121, 257 |
| abstract_inverted_index.whether | 51 |
| abstract_inverted_index.Analysis | 191 |
| abstract_inverted_index.However, | 50 |
| abstract_inverted_index.assigned | 80 |
| abstract_inverted_index.bleeding | 62 |
| abstract_inverted_index.closure; | 112 |
| abstract_inverted_index.compared | 269 |
| abstract_inverted_index.efficacy | 12, 46 |
| abstract_inverted_index.enrolled | 78 |
| abstract_inverted_index.patients | 30, 71 |
| abstract_inverted_index.received | 120 |
| abstract_inverted_index.revealed | 197 |
| abstract_inverted_index.Following | 254 |
| abstract_inverted_index.contrast, | 218 |
| abstract_inverted_index.effective | 58 |
| abstract_inverted_index.high-dose | 19, 104 |
| abstract_inverted_index.interbody | 35 |
| abstract_inverted_index.posterior | 33 |
| abstract_inverted_index.solution) | 132 |
| abstract_inverted_index.underwent | 73 |
| abstract_inverted_index.associated | 246 |
| abstract_inverted_index.hemostatic | 45 |
| abstract_inverted_index.minimizing | 25, 60, 265 |
| abstract_inverted_index.relatively | 18, 103 |
| abstract_inverted_index.throughout | 202 |
| abstract_inverted_index.tranexamic | 21 |
| abstract_inverted_index.undergoing | 31 |
| abstract_inverted_index.Literature: | 39 |
| abstract_inverted_index.application | 122 |
| abstract_inverted_index.differences | 142 |
| abstract_inverted_index.immediately | 109, 136 |
| abstract_inverted_index.intravenous | 20, 48, 52, 275 |
| abstract_inverted_index.p<0.01). | 190 |
| abstract_inverted_index.parameters, | 151 |
| abstract_inverted_index.significant | 141 |
| abstract_inverted_index.(p<0.01). | 216 |
| abstract_inverted_index.(p<0.05). | 238 |
| abstract_inverted_index.543.6±175.4 | 185 |
| abstract_inverted_index.administered | 99 |
| abstract_inverted_index.demonstrates | 42 |
| abstract_inverted_index.long-lasting | 262 |
| abstract_inverted_index.preoperative | 149 |
| abstract_inverted_index.single-level | 32, 74, 255 |
| abstract_inverted_index.(389.6±137.5 | 183 |
| abstract_inverted_index.700.3±231.4, | 187 |
| abstract_inverted_index.hematological | 150 |
| abstract_inverted_index.intravenously | 100 |
| abstract_inverted_index.postoperative | 26, 61, 164, 204, 266 |
| abstract_inverted_index.respectively; | 188 |
| abstract_inverted_index.retrospective | 3 |
| abstract_inverted_index.significantly | 168, 198 |
| abstract_inverted_index.complications, | 240 |
| abstract_inverted_index.intraoperative | 153 |
| abstract_inverted_index.study.Purpose: | 5 |
| abstract_inverted_index.thromboembolic | 243 |
| abstract_inverted_index.(PLIF).Overview | 37 |
| abstract_inverted_index.postoperatively | 237 |
| abstract_inverted_index.retrospectively | 77 |
| abstract_inverted_index.closure.Results: | 139 |
| abstract_inverted_index.unclear.Methods: | 67 |
| abstract_inverted_index.formulation.Conclusions: | 253 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| citation_normalized_percentile.value | 0.90795427 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |