Complement C5a Implication in Axonal Growth After Injury Article Swipe
Aurélie Cotten
,
Charlotte Jeanneau
,
Patrick Decherchi
,
Imad About
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cells13201729
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cells13201729
Complement C5a protein has been shown to play a major role in tissue regeneration through interaction with its receptor (C5aR) on target cells. Expression of this receptor has been reported in the nervous system which, upon injury, has no treatment to restore the lost functions. This work aimed at investigating the Complement C5a effect on axonal growth after axotomy in vitro. Primary hippocampal neurons were isolated from embryonic Wistar rats. Cell expression of C5aR mRNA was verified by RT-PCR while its membrane expression, localization, and phosphorylation were investigated by immunofluorescence. Then, the effects of C5a on injured axonal growth were investigated using a 3D-printed microfluidic device. Immunofluorescence demonstrated that the primary cultures contained only mature neurons (93%) and astrocytes (7%), but no oligodendrocytes or immature neurons. Immunofluorescence revealed a co-localization of NF-L and C5aR only in the mature neurons where C5a induced the phosphorylation of its receptor. C5a application on injured axons in the microfluidic devices significantly increased both the axonal growth speed and length. Our findings highlight a new role of C5a in regeneration demonstrating an enhancement of axonal growth after axotomy. This may provide a future therapeutic tool in the treatment of central nervous system injury.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cells13201729
- OA Status
- gold
- Cited By
- 1
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403543923
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403543923Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cells13201729Digital Object Identifier
- Title
-
Complement C5a Implication in Axonal Growth After InjuryWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-10-18Full publication date if available
- Authors
-
Aurélie Cotten, Charlotte Jeanneau, Patrick Decherchi, Imad AboutList of authors in order
- Landing page
-
https://doi.org/10.3390/cells13201729Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/cells13201729Direct OA link when available
- Concepts
-
Axotomy, C5a receptor, Immunofluorescence, Cell biology, Biology, Regeneration (biology), Hippocampal formation, Complement system, Neuroscience, Wallerian degeneration, Axon, Immunology, Immune system, AntibodyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
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38Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.immunofluorescence. | 89 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5031594309 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 4 |
| corresponding_institution_ids | https://openalex.org/I1294671590, https://openalex.org/I21491767, https://openalex.org/I4210086194 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.75 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.61605705 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |