Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury Article Swipe

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Stephanie S. Holden , Fiorella C. Grandi , Oumaima Aboubakr , Bryan Higashikubo , Frances S. Cho , Andrew H. Chang , Alejandro Osorio-Forero , Allison R. Morningstar , Vidhu Mathur , Logan J. Kuhn , Poojan Suri , Sethu Sankaranarayanan , Yaisa Andrews‐Zwilling , Andrea J. Tenner , Anita Lüthi , Eleonora Aronica , M. Ryan Corces , Ted Yednock , Jeanne T. Paz ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1126/science.abj2685

Neuroinflammation after brain injury Traumatic brain injury affects millions of people every year and is a major cause of disability worldwide. Most of the maladaptive outcomes develop months or years later and are thought to be caused by secondary injuries that are indirect and long-term effects after the initial impact. Holden et al . found that secondary and chronic neuroinflammation and neurodegeneration are caused by the C1q molecule, a mediator of the complement pathway. C1q is responsible for chronic inflammation and secondary neuronal loss specifically in the cortico-thalamo-cortical circuit. Traumatic brain injury also leads to altered brain states that are caused by the C1q complement pathway. —PRS

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Complement (music) Neuroscience Sleep (system call) Complement system Epilepsy Complement factor I Factor (programming language) Psychology Medicine Chemistry Computer science Immunology Biochemistry Phenotype Immune system Gene Programming language Operating system Complementation

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Type: article
Language: en
Landing Page: https://doi.org/10.1126/science.abj2685
OA Status: gold
Cited By: 115
References: 78
Related Works: 10
OpenAlex ID: https://openalex.org/W3196441931

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OpenAlex ID: https://openalex.org/W3196441931

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DOI: https://doi.org/10.1126/science.abj2685

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Title: Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury

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Type: article

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Language: en

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Publication year: 2021

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Publication date: 2021-09-09

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Authors: Stephanie S. Holden, Fiorella C. Grandi, Oumaima Aboubakr, Bryan Higashikubo, Frances S. Cho, Andrew H. Chang, Alejandro Osorio-Forero, Allison R. Morningstar, Vidhu Mathur, Logan J. Kuhn, Poojan Suri, Sethu Sankaranarayanan, Yaisa Andrews‐Zwilling, Andrea J. Tenner, Anita Lüthi, Eleonora Aronica, M. Ryan Corces, Ted Yednock, Jeanne T. Paz

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Landing page: https://doi.org/10.1126/science.abj2685

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OA status: gold

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OA URL: https://escholarship.org/content/qt2s49p00j/qt2s49p00j.pdf

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Concepts: Complement (music), Neuroscience, Sleep (system call), Complement system, Epilepsy, Complement factor I, Factor (programming language), Psychology, Medicine, Chemistry, Computer science, Immunology, Biochemistry, Phenotype, Immune system, Gene, Programming language, Operating system, Complementation

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Cited by: 115

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Citations by year (recent): 2025: 33, 2024: 28, 2023: 31, 2022: 15, 2021: 6

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References (count): 78

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Related works (count): 10

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