Complete Description of the Three Pathways of the Complement System in a Series of 430 Patients with Rheumatoid Arthritis Article Swipe
Dara Rodríguez-González
,
María García-González
,
Fuensanta Gómez-Bernal
,
Juan Carlos Quevedo-Abeledo
,
Agustín F. González-Rivero
,
Yolanda Fernández-Cladera
,
Elena González-López
,
J. Gonzalo Ocejo‐Vinyals
,
Alejandro Jiménez
,
Beatriz González-Toledo
,
Miguel Á. González‐Gay
,
Iván Ferraz‐Amaro
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25158360
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25158360
The complement (C) system is implicated in the etiopathogenesis of rheumatoid arthritis (RA). However, there is a lack of studies characterizing all three C pathways in RA patients. This study aimed to evaluate the association between an in-depth examination of the C system and RA patient characteristics, focusing on disease activity and the presence of rheumatoid factor and anti-citrullinated protein autoantibodies (ACPA). In a cohort of 430 RA patients, functional assays of the three C pathways (classical, alternative, and lectin) and serum levels of their components were assessed. Components included C1q (classical); factor D and properdin (alternative); lectin (lectin); C1-inhibitor; C2, C4, and C4b (classical and lectin); C3, C3a, and C4b (common); and C5, C5a, and C9 (terminal). A multivariable linear regression analysis showed significant positive correlations between C-reactive protein and C system proteins and functional assays, especially in the terminal and common pathways. Disease activity, measured by scores with or without acute phase reactants, positively correlated with the classical pathway functional test and terminal pathway products. Conversely, rheumatoid factor or ACPA presence was associated with lower classical pathway values and decreased C3a and C4b levels, suggesting complement depletion. In conclusion, RA disease activity increases C molecules and functional complement assays, while rheumatoid factor or ACPA positivity is linked to C consumption. Our study offers a detailed analysis of the complement system’s role in RA, potentially guiding the development of more targeted and effective treatment strategies.
Related Topics
Concepts
Rheumatoid arthritis
Complement (music)
Series (stratigraphy)
Complement system
Medicine
Computational biology
Arthritis
Immunology
Bioinformatics
Biology
Genetics
Immune system
Gene
Paleontology
Phenotype
Complementation
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms25158360
- https://www.mdpi.com/1422-0067/25/15/8360/pdf?version=1722411741
- OA Status
- gold
- Cited By
- 6
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401173920
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4401173920Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms25158360Digital Object Identifier
- Title
-
Complete Description of the Three Pathways of the Complement System in a Series of 430 Patients with Rheumatoid ArthritisWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-07-31Full publication date if available
- Authors
-
Dara Rodríguez-González, María García-González, Fuensanta Gómez-Bernal, Juan Carlos Quevedo-Abeledo, Agustín F. González-Rivero, Yolanda Fernández-Cladera, Elena González-López, J. Gonzalo Ocejo‐Vinyals, Alejandro Jiménez, Beatriz González-Toledo, Miguel Á. González‐Gay, Iván Ferraz‐AmaroList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms25158360Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/25/15/8360/pdf?version=1722411741Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/25/15/8360/pdf?version=1722411741Direct OA link when available
- Concepts
-
Rheumatoid arthritis, Complement (music), Series (stratigraphy), Complement system, Medicine, Computational biology, Arthritis, Immunology, Bioinformatics, Biology, Genetics, Immune system, Gene, Paleontology, Phenotype, ComplementationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6Per-year citation counts (last 5 years)
- References (count)
-
43Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.RA, | 224 |
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