Complex Involvement of Interleukin-26 in Bacterial Lung Infection Article Swipe
F. Karlhans
,
Magnus Paulsson
,
Krzysztof Piersiala
,
Jakob Sax
,
Ibrahim Mboob
,
Mizanur Rahman
,
Rokeya Sultana Rekha
,
Jesper Säfholm
,
Mikael Adner
,
Peter Bergman
,
Lars‐Olaf Cardell
,
Kristian Riesbeck
,
Anders Lindén
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2021.761317
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2021.761317
Pneumonia is a global cause of mortality, and this provides a strong incentive to improve the mechanistic understanding of innate immune responses in the lungs. Here, we characterized the involvement of the cytokine interleukin (IL)-26 in bacterial lung infection. We observed markedly increased concentrations of IL-26 in lower airway samples from patients with bacterial pneumonia and these correlated with blood neutrophil concentrations. Moreover, pathogen-associated molecular patterns (PAMPs) from both Gram-negative and -positive bacteria increased extracellular IL-26 concentrations in conditioned media from human models of alveolar epithelial cells, macrophages, and neutrophils in vitro . Stimulation with IL-26 inhibited the inherent release of neutrophil elastase and myeloperoxidase in unexposed neutrophils. This stimulation also inhibited the expression of activity makers in neutrophils exposed to Klebsiella pneumoniae. In addition, priming of human lung tissue ex vivo with exogenous IL-26 potentiated the endotoxin-induced increase in mRNA for other cytokines involved in the innate immune response, including the master Th17-regulator IL-23 and the archetype inhibitory cytokine IL-10. Finally, neutralization of endogenous IL-26 clearly increased the growth of Klebsiella pneumoniae in the macrophage culture. These findings suggest that IL-26 is involved in bacterial lung infection in a complex manner, by modulating critical aspects of innate immune responses locally and systemically in a seemingly purposeful manner and by contributing to the killing of bacteria in a way that resembles an antimicrobial peptide. Thus, IL-26 displays both diagnostic and therapeutic potential in pneumonia and deserves to be further evaluated in these respects.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2021.761317
- https://www.frontiersin.org/articles/10.3389/fimmu.2021.761317/pdf
- OA Status
- gold
- Cited By
- 12
- References
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- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3209611548
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3209611548Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2021.761317Digital Object Identifier
- Title
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Complex Involvement of Interleukin-26 in Bacterial Lung InfectionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-10-28Full publication date if available
- Authors
-
F. Karlhans, Magnus Paulsson, Krzysztof Piersiala, Jakob Sax, Ibrahim Mboob, Mizanur Rahman, Rokeya Sultana Rekha, Jesper Säfholm, Mikael Adner, Peter Bergman, Lars‐Olaf Cardell, Kristian Riesbeck, Anders LindénList of authors in order
- Landing page
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https://doi.org/10.3389/fimmu.2021.761317Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fimmu.2021.761317/pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fimmu.2021.761317/pdfDirect OA link when available
- Concepts
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Immunology, Interleukin, Lung, Lung infection, Medicine, Microbiology, Biology, Cytokine, Internal medicineTop concepts (fields/topics) attached by OpenAlex
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12Total citation count in OpenAlex
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2025: 3, 2024: 4, 2023: 3, 2022: 2Per-year citation counts (last 5 years)
- References (count)
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36Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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