Compositional Flexibility of the ER-Mitochondria Encounter Structure Article Swipe
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.11.26.625358
Yeast mitochondria receive the majority of their lipids from the endoplasmic reticulum (ER) via the heterotetrameric ERMES lipid transport complex. This complex is thought to establish a lipid transporting tube of fixed composition spanning the space between both organelles. Intriguingly, however, some of the lipid-transporting components of the complex can be replaced by an artificial ER-mitochondria tether without lipid transport activity, indicating that ERMES subunits are not all of equal importance for lipid transport. Here, we propose a model whereby lipid transfer by the ERMES complex can occur with various sub-ensembles of ERMES, and minimally with only one of the four members, namely Mmm1. Our results imply flexibility in the composition of the ERMES complex, which might help it accommodate various interorganelle distances.
Related Topics
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.11.26.625358
- https://www.biorxiv.org/content/biorxiv/early/2024/11/28/2024.11.26.625358.full.pdf
- OA Status
- green
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404820626
Raw OpenAlex JSON
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https://openalex.org/W4404820626Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2024.11.26.625358Digital Object Identifier
- Title
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Compositional Flexibility of the ER-Mitochondria Encounter StructureWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-11-28Full publication date if available
- Authors
-
Christian Covill‐Cooke, Takashi Hirashima, Shin Kawano, Joe Ganellin, Anthony L. Moody, Sabine van Schie, Arun T. John Peter, Chika Saito, Toshiya Endo, Benoı̂t KornmannList of authors in order
- Landing page
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https://doi.org/10.1101/2024.11.26.625358Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2024/11/28/2024.11.26.625358.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2024/11/28/2024.11.26.625358.full.pdfDirect OA link when available
- Concepts
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Flexibility (engineering), Mitochondrion, Chemistry, Computer science, Cell biology, Biology, Economics, ManagementTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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41Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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