Comprehensive analysis of allergen-specific IgE in COPD: Mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap Article Swipe
Hikaru Toyota
,
Naoya Sugimoto
,
Konomi Kobayashi
,
Yuki Suzuki
,
Yuri Takeshita
,
Ayaka Ito
,
Mariko Ujino
,
Fuminori Tomyo
,
Hirokazu Sakasegawa
,
Yuta Koizumi
,
Michio Kuramochi
,
Masao Yamaguchi
,
Hiroyuki Nagase
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-52909/v1
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-52909/v1
Background Although the relationship between allergic sensitization and increased respiratory symptoms of chronic obstructive pulmonary disease (COPD) has been suggested, which allergen has a significant effect on COPD pathology is unclear. This study aimed to identify the specific IgE related to clinical features of COPD and the diagnosis of asthma-COPD overlap (ACO). Methods We recruited 70 patients with COPD and analyzed 39 IgE using panel IgE test (View Allergy 39®). ACO was diagnosed according to the Japanese Respiratory Society Guidelines. Results As for perennial aeroallergens, the positivity for moth (35.4%), cockroach (23.1%), Dermatophagoides pteronyssinus (21.5%), house dust (21.5%), and Candida (21.5%) and, concerning pollen, Japanese cedar (36.9%) and Japanese cypress (23.1%) exceeded 20%. Only the positivity of IgE for Dermatophagoides pteronyssinus and house dust was significantly higher in ACO compared with that in non-ACO COPD. Moreover, it contributed to the diagnosis of ACO in an IgE class-dependent manner. Patients with cockroach IgE exhibited higher residual volume, whereas those with Japanese cedar IgE exhibited better diffusion capacity than negative patients. The contribution for ACO diagnosis by the receiver operating characteristic curve analysis was comparable among total IgE (cutoff value: 158 IU/mL), blood eosinophil count (234/µl), and fraction of exhaled nitric oxide (31.0 ppb). Conclusions The prominent role of mite-specific IgE in the diagnosis and pathology of ACO and the potentially detrimental effect of cockroach sensitization on air trapping in COPD were suggested. The finding highlights the future development of a treatment targeting IgE as a treatable trait in COPD.
Related Topics
Concepts
Asthma
Immunoglobulin E
COPD
Allergen
Immunology
Mite
Medicine
House dust mite
Allergy
Antibody
Biology
Internal medicine
Ecology
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-52909/v1
- https://www.researchsquare.com/article/rs-52909/v1.pdf
- OA Status
- green
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4236762075
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4236762075Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-52909/v1Digital Object Identifier
- Title
-
Comprehensive analysis of allergen-specific IgE in COPD: Mite-specific IgE specifically related to the diagnosis of asthma-COPD overlapWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-08-06Full publication date if available
- Authors
-
Hikaru Toyota, Naoya Sugimoto, Konomi Kobayashi, Yuki Suzuki, Yuri Takeshita, Ayaka Ito, Mariko Ujino, Fuminori Tomyo, Hirokazu Sakasegawa, Yuta Koizumi, Michio Kuramochi, Masao Yamaguchi, Hiroyuki NagaseList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-52909/v1Publisher landing page
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https://www.researchsquare.com/article/rs-52909/v1.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-52909/v1.pdfDirect OA link when available
- Concepts
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Asthma, Immunoglobulin E, COPD, Allergen, Immunology, Mite, Medicine, House dust mite, Allergy, Antibody, Biology, Internal medicine, EcologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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30Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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