Comprehensive analysis of miRNA and protein profiles within exosomes derived from canine lymphoid tumour cell lines Article Swipe
Hajime Asada
,
Hirotaka Tomiyasu
,
Takao Uchikai
,
Genki Ishihara
,
Yuko Goto‐Koshino
,
Koichi Ohno
,
Hajime Tsujimoto
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0208567
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1371/journal.pone.0208567
Exosomes are small extracellular vesicles released from almost all cell types, which play roles in cell-cell communication. Recent studies have suggested that microenvironmental crosstalk mediated by exosomes is an important factor in the escape of tumour cells from the anti-tumour immune system in human haematopoietic malignancies. Here, we conducted comprehensive analysis of the miRNA and protein profiles within the exosomes released from four canine lymphoid tumour cell lines as a model of human lymphoid tumours. The results showed that the major miRNAs and proteins extracted from the exosomes were similar among the four cell lines. However, the miRNA profiles differed among the exosomes of each cell line, which corresponded to the expression patterns of the parent cells. In the comparison of the amounts of miRNAs and proteins among the cell lines, those of three miRNAs (miR-151, miR-8908a-3p, and miR-486) and CD82 protein differed between exosomes derived from vincristine-sensitive and resistant cell lines. Further investigations are needed to elucidate the biological functions of the exosomal contents in the microenvironmental crosstalk of lymphoid tumours.
Related Topics
Concepts
Microvesicles
microRNA
Biology
Cell culture
Cell
Cell biology
Immune system
Crosstalk
Extracellular vesicle
Cancer research
Immunology
Genetics
Gene
Physics
Optics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.pone.0208567
- OA Status
- gold
- Cited By
- 24
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2949619838
All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W2949619838Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.pone.0208567Digital Object Identifier
- Title
-
Comprehensive analysis of miRNA and protein profiles within exosomes derived from canine lymphoid tumour cell linesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-04-29Full publication date if available
- Authors
-
Hajime Asada, Hirotaka Tomiyasu, Takao Uchikai, Genki Ishihara, Yuko Goto‐Koshino, Koichi Ohno, Hajime TsujimotoList of authors in order
- Landing page
-
https://doi.org/10.1371/journal.pone.0208567Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1371/journal.pone.0208567Direct OA link when available
- Concepts
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Microvesicles, microRNA, Biology, Cell culture, Cell, Cell biology, Immune system, Crosstalk, Extracellular vesicle, Cancer research, Immunology, Genetics, Gene, Physics, OpticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
24Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 5, 2023: 5, 2022: 6, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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