Comprehensive fitness maps of Hsp90 show widespread environmental dependence Article Swipe
Julia M. Flynn
,
Ammeret Rossouw
,
Pamela A. Cote-Hammarlof
,
Inês Fragata
,
David Mavor
,
Carl Hollins
,
Claudia Bank
,
Daniel N. Bolon
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1101/823468
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1101/823468
Gene-environment interactions have long been theorized to influence molecular evolution. However, the environmental dependence of most mutations remains unknown. Using deep mutational scanning, we engineered yeast with all 44,604 single codon changes encoding 14,160 amino acid variants in Hsp90 and quantified growth effects under standard conditions and under five stress conditions. To our knowledge these are the largest determined comprehensive fitness maps of point mutants. The growth of many variants differed between conditions, indicating that environment can have a large impact on Hsp90 evolution. Multiple variants provided growth advantages under individual conditions, however these variants tended to exhibit growth defects in other environments. The diversity of Hsp90 sequences observed in extant eukaryotes preferentially contains variants that supported robust growth under all tested conditions. Rather than favoring substitutions in individual conditions, the long-term selective pressure on Hsp90 may have been that of fluctuating environments, leading to robustness under a variety of conditions.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/823468
- https://www.biorxiv.org/content/biorxiv/early/2019/12/09/823468.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 66
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3106542330
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https://doi.org/10.1101/823468Digital Object Identifier
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Comprehensive fitness maps of Hsp90 show widespread environmental dependenceWork title
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preprintOpenAlex work type
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enPrimary language
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2019Year of publication
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2019-10-30Full publication date if available
- Authors
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Julia M. Flynn, Ammeret Rossouw, Pamela A. Cote-Hammarlof, Inês Fragata, David Mavor, Carl Hollins, Claudia Bank, Daniel N. BolonList of authors in order
- Landing page
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https://doi.org/10.1101/823468Publisher landing page
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https://www.biorxiv.org/content/biorxiv/early/2019/12/09/823468.full.pdfDirect link to full text PDF
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greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2019/12/09/823468.full.pdfDirect OA link when available
- Concepts
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Extant taxon, Biology, Robustness (evolution), Mutant, Genetic Fitness, Hsp90, Gene, Amino acid, Genetics, Evolutionary biology, Yeast, Computational biology, Heat shock proteinTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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