Comprehensive functional analyses of 110 complement factor B variants provide novel diagnostic and structural insights Article Swipe
Héctor Martín Merinero
,
Andrea Reparaz Suevos
,
Renee X. Goodfellow
,
Samantha Blain
,
L. Robles
,
Juan Guzman Caldentey
,
Sonsoles Martin Santamaria
,
Santiago Rodriguez de Corodba
,
Richard J. Smith
,
Yuzhou Zhang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.imbio.2025.153028
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.imbio.2025.153028
Related Topics
Concepts
Complement (music)
Computational biology
Factor (programming language)
Complement factor B
Factor H
Biology
Genetics
Complement system
Computer science
Gene
Phenotype
Antibody
Programming language
Complementation
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.imbio.2025.153028
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413236572
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4413236572Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.imbio.2025.153028Digital Object Identifier
- Title
-
Comprehensive functional analyses of 110 complement factor B variants provide novel diagnostic and structural insightsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-01Full publication date if available
- Authors
-
Héctor Martín Merinero, Andrea Reparaz Suevos, Renee X. Goodfellow, Samantha Blain, L. Robles, Juan Guzman Caldentey, Sonsoles Martin Santamaria, Santiago Rodriguez de Corodba, Richard J. Smith, Yuzhou ZhangList of authors in order
- Landing page
-
https://doi.org/10.1016/j.imbio.2025.153028Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.imbio.2025.153028Direct OA link when available
- Concepts
-
Complement (music), Computational biology, Factor (programming language), Complement factor B, Factor H, Biology, Genetics, Complement system, Computer science, Gene, Phenotype, Antibody, Programming language, ComplementationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4413236572 |
|---|---|
| doi | https://doi.org/10.1016/j.imbio.2025.153028 |
| ids.doi | https://doi.org/10.1016/j.imbio.2025.153028 |
| ids.openalex | https://openalex.org/W4413236572 |
| fwci | 0.0 |
| type | article |
| title | Comprehensive functional analyses of 110 complement factor B variants provide novel diagnostic and structural insights |
| biblio.issue | 4 |
| biblio.volume | 230 |
| biblio.last_page | 153028 |
| biblio.first_page | 153028 |
| topics[0].id | https://openalex.org/T11660 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9994999766349792 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2720 |
| topics[0].subfield.display_name | Hematology |
| topics[0].display_name | Blood groups and transfusion |
| topics[1].id | https://openalex.org/T10993 |
| topics[1].field.id | https://openalex.org/fields/24 |
| topics[1].field.display_name | Immunology and Microbiology |
| topics[1].score | 0.9986000061035156 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2403 |
| topics[1].subfield.display_name | Immunology |
| topics[1].display_name | Complement system in diseases |
| topics[2].id | https://openalex.org/T10746 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.993399977684021 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2720 |
| topics[2].subfield.display_name | Hematology |
| topics[2].display_name | Platelet Disorders and Treatments |
| is_xpac | False |
| apc_list.value | 2930 |
| apc_list.currency | USD |
| apc_list.value_usd | 2930 |
| apc_paid.value | 2930 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2930 |
| concepts[0].id | https://openalex.org/C112313634 |
| concepts[0].level | 5 |
| concepts[0].score | 0.6670097708702087 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q7886648 |
| concepts[0].display_name | Complement (music) |
| concepts[1].id | https://openalex.org/C70721500 |
| concepts[1].level | 1 |
| concepts[1].score | 0.59807950258255 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[1].display_name | Computational biology |
| concepts[2].id | https://openalex.org/C2781039887 |
| concepts[2].level | 2 |
| concepts[2].score | 0.492844820022583 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1391724 |
| concepts[2].display_name | Factor (programming language) |
| concepts[3].id | https://openalex.org/C182629451 |
| concepts[3].level | 4 |
| concepts[3].score | 0.469574898481369 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q18251054 |
| concepts[3].display_name | Complement factor B |
| concepts[4].id | https://openalex.org/C14356644 |
| concepts[4].level | 4 |
| concepts[4].score | 0.4256994426250458 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q14911975 |
| concepts[4].display_name | Factor H |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.4144236445426941 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C54355233 |
| concepts[6].level | 1 |
| concepts[6].score | 0.36209115386009216 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[6].display_name | Genetics |
| concepts[7].id | https://openalex.org/C111684460 |
| concepts[7].level | 3 |
| concepts[7].score | 0.3315660059452057 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q334848 |
| concepts[7].display_name | Complement system |
| concepts[8].id | https://openalex.org/C41008148 |
| concepts[8].level | 0 |
| concepts[8].score | 0.29321277141571045 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[8].display_name | Computer science |
| concepts[9].id | https://openalex.org/C104317684 |
| concepts[9].level | 2 |
| concepts[9].score | 0.10310596227645874 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[9].display_name | Gene |
| concepts[10].id | https://openalex.org/C127716648 |
| concepts[10].level | 3 |
| concepts[10].score | 0.09758278727531433 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q104053 |
| concepts[10].display_name | Phenotype |
| concepts[11].id | https://openalex.org/C159654299 |
| concepts[11].level | 2 |
| concepts[11].score | 0.0561576783657074 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q79460 |
| concepts[11].display_name | Antibody |
| concepts[12].id | https://openalex.org/C199360897 |
| concepts[12].level | 1 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q9143 |
| concepts[12].display_name | Programming language |
| concepts[13].id | https://openalex.org/C188082640 |
| concepts[13].level | 4 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q1780899 |
| concepts[13].display_name | Complementation |
| keywords[0].id | https://openalex.org/keywords/complement |
| keywords[0].score | 0.6670097708702087 |
| keywords[0].display_name | Complement (music) |
| keywords[1].id | https://openalex.org/keywords/computational-biology |
| keywords[1].score | 0.59807950258255 |
| keywords[1].display_name | Computational biology |
| keywords[2].id | https://openalex.org/keywords/factor |
| keywords[2].score | 0.492844820022583 |
| keywords[2].display_name | Factor (programming language) |
| keywords[3].id | https://openalex.org/keywords/complement-factor-b |
| keywords[3].score | 0.469574898481369 |
| keywords[3].display_name | Complement factor B |
| keywords[4].id | https://openalex.org/keywords/factor-h |
| keywords[4].score | 0.4256994426250458 |
| keywords[4].display_name | Factor H |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.4144236445426941 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/genetics |
| keywords[6].score | 0.36209115386009216 |
| keywords[6].display_name | Genetics |
| keywords[7].id | https://openalex.org/keywords/complement-system |
| keywords[7].score | 0.3315660059452057 |
| keywords[7].display_name | Complement system |
| keywords[8].id | https://openalex.org/keywords/computer-science |
| keywords[8].score | 0.29321277141571045 |
| keywords[8].display_name | Computer science |
| keywords[9].id | https://openalex.org/keywords/gene |
| keywords[9].score | 0.10310596227645874 |
| keywords[9].display_name | Gene |
| keywords[10].id | https://openalex.org/keywords/phenotype |
| keywords[10].score | 0.09758278727531433 |
| keywords[10].display_name | Phenotype |
| keywords[11].id | https://openalex.org/keywords/antibody |
| keywords[11].score | 0.0561576783657074 |
| keywords[11].display_name | Antibody |
| language | en |
| locations[0].id | doi:10.1016/j.imbio.2025.153028 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S164377831 |
| locations[0].source.issn | 0171-2985, 1878-3279 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 0171-2985 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Immunobiology |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Immunobiology |
| locations[0].landing_page_url | https://doi.org/10.1016/j.imbio.2025.153028 |
| indexed_in | crossref, doaj |
| authorships[0].author.id | https://openalex.org/A5086652150 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-9094-5934 |
| authorships[0].author.display_name | Héctor Martín Merinero |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Hector Martin Merinero |
| authorships[0].is_corresponding | False |
| authorships[1].author.id | https://openalex.org/A5119315870 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Andrea Reparaz Suevos |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Andrea Reparaz Suevos |
| authorships[1].is_corresponding | False |
| authorships[2].author.id | https://openalex.org/A5014803671 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Renee X. Goodfellow |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Renee X. Goodfellow |
| authorships[2].is_corresponding | False |
| authorships[3].author.id | https://openalex.org/A5104202949 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Samantha Blain |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Samantha Blain |
| authorships[3].is_corresponding | False |
| authorships[4].author.id | https://openalex.org/A5079340473 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | L. Robles |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Laura Garcia Robles |
| authorships[4].is_corresponding | False |
| authorships[5].author.id | https://openalex.org/A5059252857 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Juan Guzman Caldentey |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Juan Guzman Caldentey |
| authorships[5].is_corresponding | False |
| authorships[6].author.id | https://openalex.org/A5081416424 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Sonsoles Martin Santamaria |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Sonsoles Martin Santamaria |
| authorships[6].is_corresponding | False |
| authorships[7].author.id | https://openalex.org/A5119315871 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Santiago Rodriguez de Corodba |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Santiago Rodriguez de Corodba |
| authorships[7].is_corresponding | False |
| authorships[8].author.id | https://openalex.org/A5014833790 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-1201-6731 |
| authorships[8].author.display_name | Richard J. Smith |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Richard J.H. Smith |
| authorships[8].is_corresponding | False |
| authorships[9].author.id | https://openalex.org/A5101668018 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-8515-3388 |
| authorships[9].author.display_name | Yuzhou Zhang |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Yuzhou Zhang |
| authorships[9].is_corresponding | False |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1016/j.imbio.2025.153028 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Comprehensive functional analyses of 110 complement factor B variants provide novel diagnostic and structural insights |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11660 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9994999766349792 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2720 |
| primary_topic.subfield.display_name | Hematology |
| primary_topic.display_name | Blood groups and transfusion |
| related_works | https://openalex.org/W4240259803, https://openalex.org/W118979360, https://openalex.org/W2121855384, https://openalex.org/W1853339213, https://openalex.org/W4306152312, https://openalex.org/W1980344266, https://openalex.org/W2107997598, https://openalex.org/W2110518735, https://openalex.org/W4238019217, https://openalex.org/W2946078457 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1016/j.imbio.2025.153028 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S164377831 |
| best_oa_location.source.issn | 0171-2985, 1878-3279 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 0171-2985 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Immunobiology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Immunobiology |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.imbio.2025.153028 |
| primary_location.id | doi:10.1016/j.imbio.2025.153028 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S164377831 |
| primary_location.source.issn | 0171-2985, 1878-3279 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 0171-2985 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Immunobiology |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Immunobiology |
| primary_location.landing_page_url | https://doi.org/10.1016/j.imbio.2025.153028 |
| publication_date | 2025-07-01 |
| publication_year | 2025 |
| referenced_works_count | 0 |
| abstract_inverted_index | |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 10 |
| citation_normalized_percentile.value | 0.45854974 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |