Comprehensive genomic profiling for advanced hepatocellular carcinoma in clinical practice Article Swipe
Takeshi Terashima
,
Tatsuya Yamashita
,
Kuniaki Arai
,
Noboru Takata
,
Tomoyuki Hayashi
,
Akihiro Seki
,
Hidetoshi Nakagawa
,
Kouki Nio
,
Noriho Iida
,
Shinya Yamada
,
Tetsuro Shimakami
,
Hajime Takatori
,
Kunihiro Tsuji
,
Hajime Sunagozaka
,
Eishiro Mizukoshi
,
Masao Honda
,
Shinji Takeuchi
,
Taro Yamashita
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s12072-024-10741-y
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s12072-024-10741-y
Aim Although several therapeutic agents show efficacy in advanced hepatocellular carcinoma (HCC), biomarkers such as comprehensive genomic profiling (CGP) for the selection of second-line treatments after immunotherapy have not been established. We evaluated the value of CGP for the treatment decision in patients with HCC. Methods We retrospectively studied 52 patients with advanced HCC who received CGP tests at three tertiary hospitals between February 2022 and November 2023. Genomic profiles were obtained using one of three CGP tests; 49 and 3 patients were evaluated using tissue-based and blood-based assay, respectively. The impact of CGP results on subsequent treatment selection in clinical practice and correlations between representative gene alterations and patient characteristics or responses to immunotherapy were evaluated. Results The most frequently observed variants were TERT mutations , followed by CTNNB1 , TP53 , ARID1A , and MYC mutations. Potentially druggable gene alterations were observed in 45 patients (87%), and 34 patients (65%) were recommended to receive treatments based on specific gene alterations by a molecular tumor board. Treatments were covered by health insurance in 13 patients (25%). Five patients (10%) received the recommended treatment by the date of data cut-off. There were no differences in the efficacy of immunotherapy with respect to mutation status in hTERT , CTNNB1 , TP53 , ARID1A , and MYC . Conclusions The results of the present study suggested that druggable gene alterations may provide useful information not only in proposing alternative treatment after standard of care but also in selecting second-line targeted treatments after immunotherapy for patients with advanced HCC.
Related Topics
Concepts
Hepatocellular carcinoma
Medicine
Hepatology
Colorectal surgery
Surgical oncology
Internal medicine
Clinical Practice
Profiling (computer programming)
Clinical Oncology
Oncology
Gastroenterology
Medical physics
General surgery
Abdominal surgery
Family medicine
Cancer
Operating system
Computer science
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s12072-024-10741-y
- OA Status
- hybrid
- Cited By
- 4
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404373895
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404373895Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1007/s12072-024-10741-yDigital Object Identifier
- Title
-
Comprehensive genomic profiling for advanced hepatocellular carcinoma in clinical practiceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-11-14Full publication date if available
- Authors
-
Takeshi Terashima, Tatsuya Yamashita, Kuniaki Arai, Noboru Takata, Tomoyuki Hayashi, Akihiro Seki, Hidetoshi Nakagawa, Kouki Nio, Noriho Iida, Shinya Yamada, Tetsuro Shimakami, Hajime Takatori, Kunihiro Tsuji, Hajime Sunagozaka, Eishiro Mizukoshi, Masao Honda, Shinji Takeuchi, Taro YamashitaList of authors in order
- Landing page
-
https://doi.org/10.1007/s12072-024-10741-yPublisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1007/s12072-024-10741-yDirect OA link when available
- Concepts
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Hepatocellular carcinoma, Medicine, Hepatology, Colorectal surgery, Surgical oncology, Internal medicine, Clinical Practice, Profiling (computer programming), Clinical Oncology, Oncology, Gastroenterology, Medical physics, General surgery, Abdominal surgery, Family medicine, Cancer, Operating system, Computer scienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4Per-year citation counts (last 5 years)
- References (count)
-
31Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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