Comprehensive phage display viral antibody profiling using VirScan: potential applications in chronic immune-mediated disease Article Swipe
Related Concepts
Biology
Phage display
Computational biology
Virology
Immune system
Context (archaeology)
Antibody
Profiling (computer programming)
Immunoprecipitation
Serology
Immunology
Computer science
Paleontology
Operating system
Jed Valentiner Shrewsbury
,
Evangelin Shaloom Vitus
,
Adam Koziol
,
Anna Nenarokova
,
Tine Jess
,
Rahma Elmahdi
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1128/jvi.01102-24
· OA: W4403604872
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1128/jvi.01102-24
· OA: W4403604872
Phage immunoprecipitation sequencing (PhIP-Seq) is a high-throughput platform that uses programmable phage display for serology. VirScan, a specific PhIP-Seq library encoding viral peptides from all known human viruses, enables comprehensive quantification of past viral exposures. We review its use in immune-mediated diseases (IMDs), highlighting its utility in identifying viral exposures in the context of IMD development. Finally, we evaluate its potential for precision medicine by integrating it with other large-scale omics data sets.
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