Comprehensive Phenotyping of Peripheral Blood T Lymphocytes in Healthy Mice Article Swipe
Genny Del Zotto
,
Elisa Principi
,
Francesca Antonini
,
Serena Baratto
,
Chiara Panicucci
,
Claudio Bruno
,
Lizzia Raffaghello
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/cyto.a.24246
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1002/cyto.a.24246
T lymphocytes play a central role in antigen‐specific immune responses. They modulate the function of different immune cells both through a direct contact (receptor binding) and through the secretion of cytokines. At the same time, they are deeply involved in the direct killing of aberrant target cells. T lymphocytes derive from a bone marrow precursor that migrates in the thymus where the main differentiation steps take place. Mature CD4 and CD8 single‐positive cells, then, leave the thymus to reach the secondary lymphoid organs. T‐cell subsets and their maturation steps can be identified mainly based on the expression of extracellular markers, intracellular transcription factors and cytokine production profiles. In this review, we report, from a cytometric point of view, an overview of the most important T‐cell subpopulations and their differentiation state. © 2020 International Society for Advancement of Cytometry
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1002/cyto.a.24246
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.a.24246
- OA Status
- bronze
- Cited By
- 14
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3094113436
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3094113436Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/cyto.a.24246Digital Object Identifier
- Title
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Comprehensive Phenotyping of Peripheral Blood T Lymphocytes in Healthy MiceWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-10-24Full publication date if available
- Authors
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Genny Del Zotto, Elisa Principi, Francesca Antonini, Serena Baratto, Chiara Panicucci, Claudio Bruno, Lizzia RaffaghelloList of authors in order
- Landing page
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https://doi.org/10.1002/cyto.a.24246Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.a.24246Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.a.24246Direct OA link when available
- Concepts
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Biology, Immune system, CD8, Immunology, Cell biology, Cytotoxic T cell, Cytokine, Bone marrow, Secretion, T cell, In vitro, Endocrinology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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14Total citation count in OpenAlex
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2025: 1, 2024: 4, 2023: 3, 2022: 4, 2021: 2Per-year citation counts (last 5 years)
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63Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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