Aim: The aim of this study was to compare discrete cosine transform (DCT) and shearlet transform for positron emission tomography (PET) image compression. To identify a better transform-based compression platform. Materials and methods: 30 PET images were collected each for shearlet and DCT for compression. For calculating the compression ratio, size of the original image was divided by compressed image. With the help of SPSS software, significance between the data was calculated. Result: There was a statistical i…