Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation Article Swipe
Federico Saltarin
,
Adrian Wegmüller
,
Leire Bejarano
,
Ece Su Ildız
,
Pascale Zwicky
,
Andréj Vianin
,
Florentin Spadin
,
Klara Soukup
,
Vladimir Wischnewski
,
Britta Engelhardt
,
Urban Deutsch
,
Inês J. Marques
,
Martin Frenz
,
Johanna A. Joyce
,
Ruth Lyck
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/cancers15205071
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/cancers15205071
Melanoma frequently metastasises to the brain, and a detailed understanding of the molecular and cellular mechanisms underlying melanoma cell extravasation across the blood-brain barrier (BBB) is important for preventing brain metastasis formation. Making use of primary mouse brain microvascular endothelial cells (pMBMECs) as an in vitro BBB model, we imaged the interaction of melanoma cells into pMBMEC monolayers. We observed exclusive junctional intercalation of melanoma cells and confirmed that melanoma-induced pMBMEC barrier disruption can be rescued by protease inhibition. Interleukin (IL)-1β stimulated pMBMECs or PECAM-1-knockout (-ko) pMBMECs were employed to model compromised BBB barrier properties in vitro and to determine increased melanoma cell intercalation compared to pMBMECs with intact junctions. The newly generated brain-homing melanoma cell line YUMM1.1-BrM4 was used to reveal increased in vivo extravasation of melanoma cells across the BBB of barrier-compromised PECAM-1-deficient mice compared to controls. Taken together, our data indicate that preserving BBB integrity is an important measure to limit the formation of melanoma-brain metastasis.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/cancers15205071
- https://www.mdpi.com/2072-6694/15/20/5071/pdf?version=1697793785
- OA Status
- gold
- Cited By
- 5
- References
- 61
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387821924
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387821924Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/cancers15205071Digital Object Identifier
- Title
-
Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and ExtravasationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-20Full publication date if available
- Authors
-
Federico Saltarin, Adrian Wegmüller, Leire Bejarano, Ece Su Ildız, Pascale Zwicky, Andréj Vianin, Florentin Spadin, Klara Soukup, Vladimir Wischnewski, Britta Engelhardt, Urban Deutsch, Inês J. Marques, Martin Frenz, Johanna A. Joyce, Ruth LyckList of authors in order
- Landing page
-
https://doi.org/10.3390/cancers15205071Publisher landing page
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-
https://www.mdpi.com/2072-6694/15/20/5071/pdf?version=1697793785Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-6694/15/20/5071/pdf?version=1697793785Direct OA link when available
- Concepts
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Extravasation, Melanoma, Blood–brain barrier, Tight junction, Brain metastasis, Cancer research, In vivo, In vitro, Pathology, Metastasis, Chemistry, Medicine, Cell biology, Biology, Cancer, Neuroscience, Central nervous system, Internal medicine, Biochemistry, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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61Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.can | 73 |
| abstract_inverted_index.for | 27 |
| abstract_inverted_index.our | 141 |
| abstract_inverted_index.the | 4, 11, 21, 50, 130, 154 |
| abstract_inverted_index.use | 33 |
| abstract_inverted_index.was | 118 |
| abstract_inverted_index.cell | 18, 102, 115 |
| abstract_inverted_index.data | 142 |
| abstract_inverted_index.into | 55 |
| abstract_inverted_index.line | 116 |
| abstract_inverted_index.mice | 135 |
| abstract_inverted_index.that | 68, 144 |
| abstract_inverted_index.used | 119 |
| abstract_inverted_index.vivo | 124 |
| abstract_inverted_index.were | 87 |
| abstract_inverted_index.with | 107 |
| abstract_inverted_index.(-ko) | 85 |
| abstract_inverted_index.(BBB) | 24 |
| abstract_inverted_index.Taken | 139 |
| abstract_inverted_index.brain | 29, 37 |
| abstract_inverted_index.cells | 40, 54, 65, 128 |
| abstract_inverted_index.limit | 153 |
| abstract_inverted_index.model | 90 |
| abstract_inverted_index.mouse | 36 |
| abstract_inverted_index.newly | 111 |
| abstract_inverted_index.vitro | 45, 96 |
| abstract_inverted_index.Making | 32 |
| abstract_inverted_index.across | 20, 129 |
| abstract_inverted_index.brain, | 5 |
| abstract_inverted_index.imaged | 49 |
| abstract_inverted_index.intact | 108 |
| abstract_inverted_index.model, | 47 |
| abstract_inverted_index.pMBMEC | 56, 70 |
| abstract_inverted_index.reveal | 121 |
| abstract_inverted_index.barrier | 23, 71, 93 |
| abstract_inverted_index.measure | 151 |
| abstract_inverted_index.pMBMECs | 82, 86, 106 |
| abstract_inverted_index.primary | 35 |
| abstract_inverted_index.rescued | 75 |
| abstract_inverted_index.(IL)-1β | 80 |
| abstract_inverted_index.Melanoma | 0 |
| abstract_inverted_index.cellular | 14 |
| abstract_inverted_index.compared | 104, 136 |
| abstract_inverted_index.detailed | 8 |
| abstract_inverted_index.employed | 88 |
| abstract_inverted_index.indicate | 143 |
| abstract_inverted_index.melanoma | 17, 53, 64, 101, 114, 127 |
| abstract_inverted_index.observed | 59 |
| abstract_inverted_index.protease | 77 |
| abstract_inverted_index.(pMBMECs) | 41 |
| abstract_inverted_index.confirmed | 67 |
| abstract_inverted_index.controls. | 138 |
| abstract_inverted_index.determine | 99 |
| abstract_inverted_index.exclusive | 60 |
| abstract_inverted_index.formation | 155 |
| abstract_inverted_index.generated | 112 |
| abstract_inverted_index.important | 26, 150 |
| abstract_inverted_index.increased | 100, 122 |
| abstract_inverted_index.integrity | 147 |
| abstract_inverted_index.molecular | 12 |
| abstract_inverted_index.together, | 140 |
| abstract_inverted_index.disruption | 72 |
| abstract_inverted_index.formation. | 31 |
| abstract_inverted_index.frequently | 1 |
| abstract_inverted_index.junctional | 61 |
| abstract_inverted_index.junctions. | 109 |
| abstract_inverted_index.mechanisms | 15 |
| abstract_inverted_index.metastasis | 30 |
| abstract_inverted_index.preserving | 145 |
| abstract_inverted_index.preventing | 28 |
| abstract_inverted_index.properties | 94 |
| abstract_inverted_index.stimulated | 81 |
| abstract_inverted_index.underlying | 16 |
| abstract_inverted_index.Interleukin | 79 |
| abstract_inverted_index.blood-brain | 22 |
| abstract_inverted_index.compromised | 91 |
| abstract_inverted_index.endothelial | 39 |
| abstract_inverted_index.inhibition. | 78 |
| abstract_inverted_index.interaction | 51 |
| abstract_inverted_index.metastasis. | 158 |
| abstract_inverted_index.monolayers. | 57 |
| abstract_inverted_index.YUMM1.1-BrM4 | 117 |
| abstract_inverted_index.brain-homing | 113 |
| abstract_inverted_index.metastasises | 2 |
| abstract_inverted_index.extravasation | 19, 125 |
| abstract_inverted_index.intercalation | 62, 103 |
| abstract_inverted_index.microvascular | 38 |
| abstract_inverted_index.understanding | 9 |
| abstract_inverted_index.melanoma-brain | 157 |
| abstract_inverted_index.PECAM-1-knockout | 84 |
| abstract_inverted_index.melanoma-induced | 69 |
| abstract_inverted_index.PECAM-1-deficient | 134 |
| abstract_inverted_index.barrier-compromised | 133 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 90 |
| corresponding_author_ids | https://openalex.org/A5086503324 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I118564535 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.5299999713897705 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.71867693 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |