Computational and experimental identification of keystone interactions in Ebola virus matrix protein VP40 dimer formation
Article Swipe
Yogesh B. Narkhede
,
Roopashi Saxena
,
Tej Sharma
,
Jacob P. Conarty
,
Valentina Toro Ramirez
,
Balindile B. Motsa
,
Souad Amiar
,
Sheng Li
,
Prem P. Chapagain
,
Olaf Wiest
,
Robert V. Stahelin
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/pro.4978
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/pro.4978
The Ebola virus (EBOV) is a lipid‐enveloped virus with a negative sense RNA genome that can cause severe and often fatal viral hemorrhagic fever. The assembly and budding of EBOV is regulated by the matrix protein, VP40, which is a peripheral protein that associates with anionic lipids at the inner leaflet of the plasma membrane. VP40 is sufficient to form virus‐like particles (VLPs) from cells, which are nearly indistinguishable from authentic virions. Due to the restrictions of studying EBOV in BSL‐4 facilities, VP40 has served as a surrogate in cellular studies to examine the EBOV assembly and budding process from the host cell plasma membrane. VP40 is a dimer where inhibition of dimer formation halts budding and formation of new VLPs as well as VP40 localization to the plasma membrane inner leaflet. To better understand VP40 dimer stability and critical amino acids to VP40 dimer formation, we integrated computational approaches with experimental validation. Site saturation/alanine scanning calculation, combined with molecular mechanics‐based generalized Born with Poisson‐Boltzmann surface area (MM‐GB/PBSA) method and molecular dynamics simulations were used to predict the energetic contribution of amino acids to VP40 dimer stability and the hydrogen bonding network across the dimer interface. These studies revealed several previously unknown interactions and critical residues predicted to impact VP40 dimer formation. In vitro and cellular studies were then pursued for a subset of VP40 mutations demonstrating reduction in dimer formation (in vitro) or plasma membrane localization (in cells). Together, the computational and experimental approaches revealed critical residues for VP40 dimer stability in an alpha‐helical interface (between residues 106–117) as well as in a loop region (between residues 52–61) below this alpha‐helical region. This study sheds light on the structural origins of VP40 dimer formation and may inform the design of a small molecule that can disrupt VP40 dimer stability.
Related Topics
Concepts
VP40
Viral matrix protein
Ebola virus
Dimer
Chemistry
Alanine scanning
Cell biology
Budding
Biology
Biophysics
Virology
Virus
Biochemistry
Mutant
Gene
Mutagenesis
Organic chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/pro.4978
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4978
- OA Status
- hybrid
- Cited By
- 5
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4394606965
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4394606965Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/pro.4978Digital Object Identifier
- Title
-
Computational and experimental identification of keystone interactions in Ebola virus matrix protein
VP40 dimer formationWork title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-09Full publication date if available
- Authors
-
Yogesh B. Narkhede, Roopashi Saxena, Tej Sharma, Jacob P. Conarty, Valentina Toro Ramirez, Balindile B. Motsa, Souad Amiar, Sheng Li, Prem P. Chapagain, Olaf Wiest, Robert V. StahelinList of authors in order
- Landing page
-
https://doi.org/10.1002/pro.4978Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4978Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4978Direct OA link when available
- Concepts
-
VP40, Viral matrix protein, Ebola virus, Dimer, Chemistry, Alanine scanning, Cell biology, Budding, Biology, Biophysics, Virology, Virus, Biochemistry, Mutant, Gene, Mutagenesis, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
40Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4394606965 |
|---|---|
| doi | https://doi.org/10.1002/pro.4978 |
| ids.doi | https://doi.org/10.1002/pro.4978 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38591637 |
| ids.openalex | https://openalex.org/W4394606965 |
| fwci | 5.19055999 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000235 |
| mesh[1].descriptor_ui | D029043 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | genetics |
| mesh[1].descriptor_name | Ebolavirus |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D029043 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | Ebolavirus |
| mesh[3].qualifier_ui | Q000378 |
| mesh[3].descriptor_ui | D019142 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | metabolism |
| mesh[3].descriptor_name | Hemorrhagic Fever, Ebola |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D002462 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Cell Membrane |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D056004 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Molecular Dynamics Simulation |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D000596 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | Amino Acids |
| mesh[7].qualifier_ui | Q000235 |
| mesh[7].descriptor_ui | D014763 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | genetics |
| mesh[7].descriptor_name | Viral Matrix Proteins |
| mesh[8].qualifier_ui | Q000737 |
| mesh[8].descriptor_ui | D014763 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | chemistry |
| mesh[8].descriptor_name | Viral Matrix Proteins |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D014763 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Viral Matrix Proteins |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D006801 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Humans |
| mesh[11].qualifier_ui | Q000235 |
| mesh[11].descriptor_ui | D029043 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | genetics |
| mesh[11].descriptor_name | Ebolavirus |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D029043 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | Ebolavirus |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D019142 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Hemorrhagic Fever, Ebola |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D002462 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Cell Membrane |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D056004 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Molecular Dynamics Simulation |
| mesh[16].qualifier_ui | Q000378 |
| mesh[16].descriptor_ui | D000596 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | metabolism |
| mesh[16].descriptor_name | Amino Acids |
| mesh[17].qualifier_ui | Q000235 |
| mesh[17].descriptor_ui | D014763 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | genetics |
| mesh[17].descriptor_name | Viral Matrix Proteins |
| mesh[18].qualifier_ui | Q000737 |
| mesh[18].descriptor_ui | D014763 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | chemistry |
| mesh[18].descriptor_name | Viral Matrix Proteins |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D014763 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Viral Matrix Proteins |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D006801 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Humans |
| mesh[21].qualifier_ui | Q000235 |
| mesh[21].descriptor_ui | D029043 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | genetics |
| mesh[21].descriptor_name | Ebolavirus |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D029043 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | Ebolavirus |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D019142 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | Hemorrhagic Fever, Ebola |
| mesh[24].qualifier_ui | Q000378 |
| mesh[24].descriptor_ui | D002462 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | metabolism |
| mesh[24].descriptor_name | Cell Membrane |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D056004 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Molecular Dynamics Simulation |
| mesh[26].qualifier_ui | Q000378 |
| mesh[26].descriptor_ui | D000596 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | metabolism |
| mesh[26].descriptor_name | Amino Acids |
| mesh[27].qualifier_ui | Q000235 |
| mesh[27].descriptor_ui | D014763 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | genetics |
| mesh[27].descriptor_name | Viral Matrix Proteins |
| mesh[28].qualifier_ui | Q000737 |
| mesh[28].descriptor_ui | D014763 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | chemistry |
| mesh[28].descriptor_name | Viral Matrix Proteins |
| mesh[29].qualifier_ui | Q000378 |
| mesh[29].descriptor_ui | D014763 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | metabolism |
| mesh[29].descriptor_name | Viral Matrix Proteins |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D006801 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Humans |
| mesh[31].qualifier_ui | Q000235 |
| mesh[31].descriptor_ui | D029043 |
| mesh[31].is_major_topic | True |
| mesh[31].qualifier_name | genetics |
| mesh[31].descriptor_name | Ebolavirus |
| mesh[32].qualifier_ui | Q000378 |
| mesh[32].descriptor_ui | D029043 |
| mesh[32].is_major_topic | True |
| mesh[32].qualifier_name | metabolism |
| mesh[32].descriptor_name | Ebolavirus |
| mesh[33].qualifier_ui | Q000378 |
| mesh[33].descriptor_ui | D019142 |
| mesh[33].is_major_topic | True |
| mesh[33].qualifier_name | metabolism |
| mesh[33].descriptor_name | Hemorrhagic Fever, Ebola |
| mesh[34].qualifier_ui | Q000378 |
| mesh[34].descriptor_ui | D002462 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | metabolism |
| mesh[34].descriptor_name | Cell Membrane |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D056004 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Molecular Dynamics Simulation |
| mesh[36].qualifier_ui | Q000378 |
| mesh[36].descriptor_ui | D000596 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | metabolism |
| mesh[36].descriptor_name | Amino Acids |
| mesh[37].qualifier_ui | Q000235 |
| mesh[37].descriptor_ui | D014763 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | genetics |
| mesh[37].descriptor_name | Viral Matrix Proteins |
| mesh[38].qualifier_ui | Q000737 |
| mesh[38].descriptor_ui | D014763 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | chemistry |
| mesh[38].descriptor_name | Viral Matrix Proteins |
| mesh[39].qualifier_ui | Q000378 |
| mesh[39].descriptor_ui | D014763 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | metabolism |
| mesh[39].descriptor_name | Viral Matrix Proteins |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D006801 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Humans |
| mesh[41].qualifier_ui | Q000235 |
| mesh[41].descriptor_ui | D029043 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | genetics |
| mesh[41].descriptor_name | Ebolavirus |
| mesh[42].qualifier_ui | Q000378 |
| mesh[42].descriptor_ui | D029043 |
| mesh[42].is_major_topic | True |
| mesh[42].qualifier_name | metabolism |
| mesh[42].descriptor_name | Ebolavirus |
| mesh[43].qualifier_ui | Q000378 |
| mesh[43].descriptor_ui | D019142 |
| mesh[43].is_major_topic | True |
| mesh[43].qualifier_name | metabolism |
| mesh[43].descriptor_name | Hemorrhagic Fever, Ebola |
| mesh[44].qualifier_ui | Q000378 |
| mesh[44].descriptor_ui | D002462 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | metabolism |
| mesh[44].descriptor_name | Cell Membrane |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D056004 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Molecular Dynamics Simulation |
| mesh[46].qualifier_ui | Q000378 |
| mesh[46].descriptor_ui | D000596 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | metabolism |
| mesh[46].descriptor_name | Amino Acids |
| mesh[47].qualifier_ui | Q000235 |
| mesh[47].descriptor_ui | D014763 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | genetics |
| mesh[47].descriptor_name | Viral Matrix Proteins |
| mesh[48].qualifier_ui | Q000737 |
| mesh[48].descriptor_ui | D014763 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | chemistry |
| mesh[48].descriptor_name | Viral Matrix Proteins |
| mesh[49].qualifier_ui | Q000378 |
| mesh[49].descriptor_ui | D014763 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | metabolism |
| mesh[49].descriptor_name | Viral Matrix Proteins |
| type | article |
| title | Computational and experimental identification of keystone interactions in Ebola virus matrix protein |
| biblio.issue | 5 |
| biblio.volume | 33 |
| biblio.last_page | e4978 |
| biblio.first_page | e4978 |
| topics[0].id | https://openalex.org/T11581 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2725 |
| topics[0].subfield.display_name | Infectious Diseases |
| topics[0].display_name | Viral Infections and Outbreaks Research |
| topics[1].id | https://openalex.org/T10340 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9911999702453613 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2713 |
| topics[1].subfield.display_name | Epidemiology |
| topics[1].display_name | Hepatitis B Virus Studies |
| topics[2].id | https://openalex.org/T10167 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.98580002784729 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2713 |
| topics[2].subfield.display_name | Epidemiology |
| topics[2].display_name | Influenza Virus Research Studies |
| funders[0].id | https://openalex.org/F4320337349 |
| funders[0].ror | https://ror.org/00fj8a872 |
| funders[0].display_name | NIH Office of the Director |
| funders[1].id | https://openalex.org/F4320337355 |
| funders[1].ror | https://ror.org/043z4tv69 |
| funders[1].display_name | National Institute of Allergy and Infectious Diseases |
| is_xpac | False |
| apc_list.value | 4070 |
| apc_list.currency | USD |
| apc_list.value_usd | 4070 |
| apc_paid.value | 4070 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 4070 |
| concepts[0].id | https://openalex.org/C86295872 |
| concepts[0].level | 4 |
| concepts[0].score | 0.8932816982269287 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q24779573 |
| concepts[0].display_name | VP40 |
| concepts[1].id | https://openalex.org/C68434959 |
| concepts[1].level | 3 |
| concepts[1].score | 0.7227665185928345 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1908996 |
| concepts[1].display_name | Viral matrix protein |
| concepts[2].id | https://openalex.org/C2777469322 |
| concepts[2].level | 3 |
| concepts[2].score | 0.693041980266571 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q8064876 |
| concepts[2].display_name | Ebola virus |
| concepts[3].id | https://openalex.org/C2779546866 |
| concepts[3].level | 2 |
| concepts[3].score | 0.47069716453552246 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q531306 |
| concepts[3].display_name | Dimer |
| concepts[4].id | https://openalex.org/C185592680 |
| concepts[4].level | 0 |
| concepts[4].score | 0.44270896911621094 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[4].display_name | Chemistry |
| concepts[5].id | https://openalex.org/C2780227090 |
| concepts[5].level | 5 |
| concepts[5].score | 0.4380251467227936 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q2636892 |
| concepts[5].display_name | Alanine scanning |
| concepts[6].id | https://openalex.org/C95444343 |
| concepts[6].level | 1 |
| concepts[6].score | 0.43267709016799927 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[6].display_name | Cell biology |
| concepts[7].id | https://openalex.org/C198410946 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4164334535598755 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q845312 |
| concepts[7].display_name | Budding |
| concepts[8].id | https://openalex.org/C86803240 |
| concepts[8].level | 0 |
| concepts[8].score | 0.3747420012950897 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[8].display_name | Biology |
| concepts[9].id | https://openalex.org/C12554922 |
| concepts[9].level | 1 |
| concepts[9].score | 0.36217421293258667 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7100 |
| concepts[9].display_name | Biophysics |
| concepts[10].id | https://openalex.org/C159047783 |
| concepts[10].level | 1 |
| concepts[10].score | 0.34302186965942383 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7215 |
| concepts[10].display_name | Virology |
| concepts[11].id | https://openalex.org/C2522874641 |
| concepts[11].level | 2 |
| concepts[11].score | 0.32516950368881226 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q808 |
| concepts[11].display_name | Virus |
| concepts[12].id | https://openalex.org/C55493867 |
| concepts[12].level | 1 |
| concepts[12].score | 0.2222769856452942 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[12].display_name | Biochemistry |
| concepts[13].id | https://openalex.org/C143065580 |
| concepts[13].level | 3 |
| concepts[13].score | 0.1415145993232727 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q3285695 |
| concepts[13].display_name | Mutant |
| concepts[14].id | https://openalex.org/C104317684 |
| concepts[14].level | 2 |
| concepts[14].score | 0.07199332118034363 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[14].display_name | Gene |
| concepts[15].id | https://openalex.org/C16318435 |
| concepts[15].level | 4 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q149299 |
| concepts[15].display_name | Mutagenesis |
| concepts[16].id | https://openalex.org/C178790620 |
| concepts[16].level | 1 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q11351 |
| concepts[16].display_name | Organic chemistry |
| keywords[0].id | https://openalex.org/keywords/vp40 |
| keywords[0].score | 0.8932816982269287 |
| keywords[0].display_name | VP40 |
| keywords[1].id | https://openalex.org/keywords/viral-matrix-protein |
| keywords[1].score | 0.7227665185928345 |
| keywords[1].display_name | Viral matrix protein |
| keywords[2].id | https://openalex.org/keywords/ebola-virus |
| keywords[2].score | 0.693041980266571 |
| keywords[2].display_name | Ebola virus |
| keywords[3].id | https://openalex.org/keywords/dimer |
| keywords[3].score | 0.47069716453552246 |
| keywords[3].display_name | Dimer |
| keywords[4].id | https://openalex.org/keywords/chemistry |
| keywords[4].score | 0.44270896911621094 |
| keywords[4].display_name | Chemistry |
| keywords[5].id | https://openalex.org/keywords/alanine-scanning |
| keywords[5].score | 0.4380251467227936 |
| keywords[5].display_name | Alanine scanning |
| keywords[6].id | https://openalex.org/keywords/cell-biology |
| keywords[6].score | 0.43267709016799927 |
| keywords[6].display_name | Cell biology |
| keywords[7].id | https://openalex.org/keywords/budding |
| keywords[7].score | 0.4164334535598755 |
| keywords[7].display_name | Budding |
| keywords[8].id | https://openalex.org/keywords/biology |
| keywords[8].score | 0.3747420012950897 |
| keywords[8].display_name | Biology |
| keywords[9].id | https://openalex.org/keywords/biophysics |
| keywords[9].score | 0.36217421293258667 |
| keywords[9].display_name | Biophysics |
| keywords[10].id | https://openalex.org/keywords/virology |
| keywords[10].score | 0.34302186965942383 |
| keywords[10].display_name | Virology |
| keywords[11].id | https://openalex.org/keywords/virus |
| keywords[11].score | 0.32516950368881226 |
| keywords[11].display_name | Virus |
| keywords[12].id | https://openalex.org/keywords/biochemistry |
| keywords[12].score | 0.2222769856452942 |
| keywords[12].display_name | Biochemistry |
| keywords[13].id | https://openalex.org/keywords/mutant |
| keywords[13].score | 0.1415145993232727 |
| keywords[13].display_name | Mutant |
| keywords[14].id | https://openalex.org/keywords/gene |
| keywords[14].score | 0.07199332118034363 |
| keywords[14].display_name | Gene |
| language | en |
| locations[0].id | doi:10.1002/pro.4978 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S156919612 |
| locations[0].source.issn | 0961-8368, 1469-896X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0961-8368 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Protein Science |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_lineage_names | Wiley |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4978 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Protein Science |
| locations[0].landing_page_url | https://doi.org/10.1002/pro.4978 |
| locations[1].id | pmid:38591637 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Protein science : a publication of the Protein Society |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38591637 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11002992 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Protein Sci |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11002992 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5003552985 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-4358-2912 |
| authorships[0].author.display_name | Yogesh B. Narkhede |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I107639228 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA |
| authorships[0].institutions[0].id | https://openalex.org/I107639228 |
| authorships[0].institutions[0].ror | https://ror.org/00mkhxb43 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I107639228 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | University of Notre Dame |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Yogesh Narkhede |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA |
| authorships[1].author.id | https://openalex.org/A5024941103 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-5548-4773 |
| authorships[1].author.display_name | Roopashi Saxena |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I219193219 |
| authorships[1].affiliations[0].raw_affiliation_string | Borch Department of Medicinal Chemistry and Molecular Pharmacology and The Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA |
| authorships[1].institutions[0].id | https://openalex.org/I219193219 |
| authorships[1].institutions[0].ror | https://ror.org/02dqehb95 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I219193219 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Purdue University West Lafayette |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Roopashi Saxena |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Borch Department of Medicinal Chemistry and Molecular Pharmacology and The Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA |
| authorships[2].author.id | https://openalex.org/A5077523953 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6095-4370 |
| authorships[2].author.display_name | Tej Sharma |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I19700959 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Physics, Florida International University, Miami, Florida, USA |
| authorships[2].institutions[0].id | https://openalex.org/I19700959 |
| authorships[2].institutions[0].ror | https://ror.org/02gz6gg07 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I19700959 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Florida International University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Tej Sharma |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Physics, Florida International University, Miami, Florida, USA |
| authorships[3].author.id | https://openalex.org/A5092060740 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Jacob P. Conarty |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I219193219 |
| authorships[3].affiliations[0].raw_affiliation_string | Borch Department of Medicinal Chemistry and Molecular Pharmacology and The Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA |
| authorships[3].institutions[0].id | https://openalex.org/I219193219 |
| authorships[3].institutions[0].ror | https://ror.org/02dqehb95 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I219193219 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Purdue University West Lafayette |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Jacob P. Conarty |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Borch Department of Medicinal Chemistry and Molecular Pharmacology and The Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA |
| authorships[4].author.id | https://openalex.org/A5101333641 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Valentina Toro Ramirez |
| authorships[4].countries | US |
| authorships[4].affiliations[0].raw_affiliation_string | Pharmaceutical Chemistry Universidad CES Medellín Colombia |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I219193219 |
| authorships[4].affiliations[1].raw_affiliation_string | Borch Department of Medicinal Chemistry and Molecular Pharmacology and The Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA |
| authorships[4].institutions[0].id | https://openalex.org/I219193219 |
| authorships[4].institutions[0].ror | https://ror.org/02dqehb95 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I219193219 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Purdue University West Lafayette |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Valentina Toro Ramirez |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Borch Department of Medicinal Chemistry and Molecular Pharmacology and The Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA, Pharmaceutical Chemistry Universidad CES Medellín Colombia |
| authorships[5].author.id | https://openalex.org/A5039002064 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Balindile B. Motsa |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I219193219 |
| authorships[5].affiliations[0].raw_affiliation_string | Borch Department of Medicinal Chemistry and Molecular Pharmacology and The Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA |
| authorships[5].institutions[0].id | https://openalex.org/I219193219 |
| authorships[5].institutions[0].ror | https://ror.org/02dqehb95 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I219193219 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Purdue University West Lafayette |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Balindile B. Motsa |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Borch Department of Medicinal Chemistry and Molecular Pharmacology and The Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA |
| authorships[6].author.id | https://openalex.org/A5019359436 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-6117-0746 |
| authorships[6].author.display_name | Souad Amiar |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I219193219 |
| authorships[6].affiliations[0].raw_affiliation_string | Borch Department of Medicinal Chemistry and Molecular Pharmacology and The Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA |
| authorships[6].institutions[0].id | https://openalex.org/I219193219 |
| authorships[6].institutions[0].ror | https://ror.org/02dqehb95 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I219193219 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Purdue University West Lafayette |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Souad Amiar |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Borch Department of Medicinal Chemistry and Molecular Pharmacology and The Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA |
| authorships[7].author.id | https://openalex.org/A5100359827 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-9073-6809 |
| authorships[7].author.display_name | Sheng Li |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I36258959 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Medicine, University of California, San Diego, California, USA |
| authorships[7].institutions[0].id | https://openalex.org/I36258959 |
| authorships[7].institutions[0].ror | https://ror.org/0168r3w48 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I36258959 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | University of California, San Diego |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Sheng Li |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Medicine, University of California, San Diego, California, USA |
| authorships[8].author.id | https://openalex.org/A5071186045 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-0999-4975 |
| authorships[8].author.display_name | Prem P. Chapagain |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I19700959 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Physics, Florida International University, Miami, Florida, USA |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I19700959 |
| authorships[8].affiliations[1].raw_affiliation_string | Biomolecular Sciences Institute, Florida International University, Miami, Florida, USA |
| authorships[8].institutions[0].id | https://openalex.org/I19700959 |
| authorships[8].institutions[0].ror | https://ror.org/02gz6gg07 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I19700959 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Florida International University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Prem P. Chapagain |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | Biomolecular Sciences Institute, Florida International University, Miami, Florida, USA, Department of Physics, Florida International University, Miami, Florida, USA |
| authorships[9].author.id | https://openalex.org/A5029114040 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-9316-7720 |
| authorships[9].author.display_name | Olaf Wiest |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I107639228 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA |
| authorships[9].institutions[0].id | https://openalex.org/I107639228 |
| authorships[9].institutions[0].ror | https://ror.org/00mkhxb43 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I107639228 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | University of Notre Dame |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Olaf Wiest |
| authorships[9].is_corresponding | True |
| authorships[9].raw_affiliation_strings | Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USA |
| authorships[10].author.id | https://openalex.org/A5078195240 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-5443-7863 |
| authorships[10].author.display_name | Robert V. Stahelin |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I219193219 |
| authorships[10].affiliations[0].raw_affiliation_string | Borch Department of Medicinal Chemistry and Molecular Pharmacology and The Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA |
| authorships[10].institutions[0].id | https://openalex.org/I219193219 |
| authorships[10].institutions[0].ror | https://ror.org/02dqehb95 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I219193219 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | Purdue University West Lafayette |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Robert V. Stahelin |
| authorships[10].is_corresponding | True |
| authorships[10].raw_affiliation_strings | Borch Department of Medicinal Chemistry and Molecular Pharmacology and The Purdue Institute for Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, Indiana, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4978 |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2024-04-10T00:00:00 |
| display_name | Computational and experimental identification of keystone interactions in Ebola virus matrix protein |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11581 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2725 |
| primary_topic.subfield.display_name | Infectious Diseases |
| primary_topic.display_name | Viral Infections and Outbreaks Research |
| related_works | https://openalex.org/W2028452224, https://openalex.org/W1990867043, https://openalex.org/W2171864254, https://openalex.org/W2281257479, https://openalex.org/W3004849963, https://openalex.org/W791318610, https://openalex.org/W2317180002, https://openalex.org/W2016300742, https://openalex.org/W4393132015, https://openalex.org/W2169388729 |
| cited_by_count | 5 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 3 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1002/pro.4978 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S156919612 |
| best_oa_location.source.issn | 0961-8368, 1469-896X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 0961-8368 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Protein Science |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_lineage_names | Wiley |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4978 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Protein Science |
| best_oa_location.landing_page_url | https://doi.org/10.1002/pro.4978 |
| primary_location.id | doi:10.1002/pro.4978 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S156919612 |
| primary_location.source.issn | 0961-8368, 1469-896X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0961-8368 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Protein Science |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_lineage_names | Wiley |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4978 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Protein Science |
| primary_location.landing_page_url | https://doi.org/10.1002/pro.4978 |
| publication_date | 2024-04-09 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2070180947, https://openalex.org/W2165103929, https://openalex.org/W1987695412, https://openalex.org/W3163579916, https://openalex.org/W2780523853, https://openalex.org/W2552279413, https://openalex.org/W2138741496, https://openalex.org/W190765717, https://openalex.org/W2783011783, https://openalex.org/W2156633263, https://openalex.org/W2163414409, https://openalex.org/W2126069516, https://openalex.org/W2018741273, https://openalex.org/W2891199551, https://openalex.org/W2068761461, https://openalex.org/W2111014305, https://openalex.org/W2109154308, https://openalex.org/W2021520922, https://openalex.org/W3180883500, https://openalex.org/W4391310336, https://openalex.org/W2236986934, https://openalex.org/W3156401441, https://openalex.org/W1963157969, https://openalex.org/W3042332451, https://openalex.org/W4384484640, https://openalex.org/W3015140048, https://openalex.org/W4310567689, https://openalex.org/W3046751266, https://openalex.org/W2071607445, https://openalex.org/W4205668988, https://openalex.org/W1990867043, https://openalex.org/W4323567118, https://openalex.org/W1848707615, https://openalex.org/W3090056832, https://openalex.org/W4211196614, https://openalex.org/W4319656203, https://openalex.org/W4382680779, https://openalex.org/W2586779340, https://openalex.org/W4394606965, https://openalex.org/W1607931568 |
| referenced_works_count | 40 |
| abstract_inverted_index.a | 6, 10, 40, 87, 108, 222, 264, 292 |
| abstract_inverted_index.In | 213 |
| abstract_inverted_index.To | 133 |
| abstract_inverted_index.an | 254 |
| abstract_inverted_index.as | 86, 122, 124, 260, 262 |
| abstract_inverted_index.at | 48 |
| abstract_inverted_index.by | 33 |
| abstract_inverted_index.in | 80, 89, 229, 253, 263 |
| abstract_inverted_index.is | 5, 31, 39, 57, 107 |
| abstract_inverted_index.of | 29, 52, 77, 112, 119, 181, 224, 282, 291 |
| abstract_inverted_index.on | 278 |
| abstract_inverted_index.or | 234 |
| abstract_inverted_index.to | 59, 74, 92, 127, 143, 176, 184, 208 |
| abstract_inverted_index.we | 147 |
| abstract_inverted_index.(in | 232, 238 |
| abstract_inverted_index.Due | 73 |
| abstract_inverted_index.RNA | 13 |
| abstract_inverted_index.The | 1, 25 |
| abstract_inverted_index.and | 19, 27, 97, 117, 139, 170, 188, 204, 215, 243, 286 |
| abstract_inverted_index.are | 67 |
| abstract_inverted_index.can | 16, 296 |
| abstract_inverted_index.for | 221, 249 |
| abstract_inverted_index.has | 84 |
| abstract_inverted_index.may | 287 |
| abstract_inverted_index.new | 120 |
| abstract_inverted_index.the | 34, 49, 53, 75, 94, 101, 128, 178, 189, 194, 241, 279, 289 |
| abstract_inverted_index.Born | 163 |
| abstract_inverted_index.EBOV | 30, 79, 95 |
| abstract_inverted_index.Site | 154 |
| abstract_inverted_index.This | 274 |
| abstract_inverted_index.VLPs | 121 |
| abstract_inverted_index.VP40 | 56, 83, 106, 125, 136, 144, 185, 210, 225, 250, 283, 298 |
| abstract_inverted_index.area | 167 |
| abstract_inverted_index.cell | 103 |
| abstract_inverted_index.form | 60 |
| abstract_inverted_index.from | 64, 70, 100 |
| abstract_inverted_index.host | 102 |
| abstract_inverted_index.loop | 265 |
| abstract_inverted_index.that | 15, 43, 295 |
| abstract_inverted_index.then | 219 |
| abstract_inverted_index.this | 271 |
| abstract_inverted_index.used | 175 |
| abstract_inverted_index.well | 123, 261 |
| abstract_inverted_index.were | 174, 218 |
| abstract_inverted_index.with | 9, 45, 151, 159, 164 |
| abstract_inverted_index.Ebola | 2 |
| abstract_inverted_index.These | 197 |
| abstract_inverted_index.VP40, | 37 |
| abstract_inverted_index.acids | 142, 183 |
| abstract_inverted_index.amino | 141, 182 |
| abstract_inverted_index.below | 270 |
| abstract_inverted_index.cause | 17 |
| abstract_inverted_index.dimer | 109, 113, 137, 145, 186, 195, 211, 230, 251, 284, 299 |
| abstract_inverted_index.fatal | 21 |
| abstract_inverted_index.halts | 115 |
| abstract_inverted_index.inner | 50, 131 |
| abstract_inverted_index.light | 277 |
| abstract_inverted_index.often | 20 |
| abstract_inverted_index.sense | 12 |
| abstract_inverted_index.sheds | 276 |
| abstract_inverted_index.small | 293 |
| abstract_inverted_index.study | 275 |
| abstract_inverted_index.viral | 22 |
| abstract_inverted_index.virus | 3, 8 |
| abstract_inverted_index.vitro | 214 |
| abstract_inverted_index.where | 110 |
| abstract_inverted_index.which | 38, 66 |
| abstract_inverted_index.(EBOV) | 4 |
| abstract_inverted_index.(VLPs) | 63 |
| abstract_inverted_index.across | 193 |
| abstract_inverted_index.better | 134 |
| abstract_inverted_index.cells, | 65 |
| abstract_inverted_index.design | 290 |
| abstract_inverted_index.fever. | 24 |
| abstract_inverted_index.genome | 14 |
| abstract_inverted_index.impact | 209 |
| abstract_inverted_index.inform | 288 |
| abstract_inverted_index.lipids | 47 |
| abstract_inverted_index.matrix | 35 |
| abstract_inverted_index.method | 169 |
| abstract_inverted_index.nearly | 68 |
| abstract_inverted_index.plasma | 54, 104, 129, 235 |
| abstract_inverted_index.region | 266 |
| abstract_inverted_index.served | 85 |
| abstract_inverted_index.severe | 18 |
| abstract_inverted_index.subset | 223 |
| abstract_inverted_index.vitro) | 233 |
| abstract_inverted_index.BSL‐4 | 81 |
| abstract_inverted_index.anionic | 46 |
| abstract_inverted_index.bonding | 191 |
| abstract_inverted_index.budding | 28, 98, 116 |
| abstract_inverted_index.cells). | 239 |
| abstract_inverted_index.disrupt | 297 |
| abstract_inverted_index.examine | 93 |
| abstract_inverted_index.leaflet | 51 |
| abstract_inverted_index.network | 192 |
| abstract_inverted_index.origins | 281 |
| abstract_inverted_index.predict | 177 |
| abstract_inverted_index.process | 99 |
| abstract_inverted_index.protein | 42 |
| abstract_inverted_index.pursued | 220 |
| abstract_inverted_index.region. | 273 |
| abstract_inverted_index.several | 200 |
| abstract_inverted_index.studies | 91, 198, 217 |
| abstract_inverted_index.surface | 166 |
| abstract_inverted_index.unknown | 202 |
| abstract_inverted_index.(between | 257, 267 |
| abstract_inverted_index.52–61) | 269 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.assembly | 26, 96 |
| abstract_inverted_index.cellular | 90, 216 |
| abstract_inverted_index.combined | 158 |
| abstract_inverted_index.critical | 140, 205, 247 |
| abstract_inverted_index.dynamics | 172 |
| abstract_inverted_index.hydrogen | 190 |
| abstract_inverted_index.leaflet. | 132 |
| abstract_inverted_index.membrane | 130, 236 |
| abstract_inverted_index.molecule | 294 |
| abstract_inverted_index.negative | 11 |
| abstract_inverted_index.protein, | 36 |
| abstract_inverted_index.residues | 206, 248, 258, 268 |
| abstract_inverted_index.revealed | 199, 246 |
| abstract_inverted_index.scanning | 156 |
| abstract_inverted_index.studying | 78 |
| abstract_inverted_index.virions. | 72 |
| abstract_inverted_index.Together, | 240 |
| abstract_inverted_index.authentic | 71 |
| abstract_inverted_index.energetic | 179 |
| abstract_inverted_index.formation | 114, 118, 231, 285 |
| abstract_inverted_index.interface | 256 |
| abstract_inverted_index.membrane. | 55, 105 |
| abstract_inverted_index.molecular | 160, 171 |
| abstract_inverted_index.mutations | 226 |
| abstract_inverted_index.particles | 62 |
| abstract_inverted_index.predicted | 207 |
| abstract_inverted_index.reduction | 228 |
| abstract_inverted_index.regulated | 32 |
| abstract_inverted_index.stability | 138, 187, 252 |
| abstract_inverted_index.surrogate | 88 |
| abstract_inverted_index.106–117) | 259 |
| abstract_inverted_index.approaches | 150, 245 |
| abstract_inverted_index.associates | 44 |
| abstract_inverted_index.formation, | 146 |
| abstract_inverted_index.formation. | 212 |
| abstract_inverted_index.inhibition | 111 |
| abstract_inverted_index.integrated | 148 |
| abstract_inverted_index.interface. | 196 |
| abstract_inverted_index.peripheral | 41 |
| abstract_inverted_index.previously | 201 |
| abstract_inverted_index.stability. | 300 |
| abstract_inverted_index.structural | 280 |
| abstract_inverted_index.sufficient | 58 |
| abstract_inverted_index.understand | 135 |
| abstract_inverted_index.facilities, | 82 |
| abstract_inverted_index.generalized | 162 |
| abstract_inverted_index.hemorrhagic | 23 |
| abstract_inverted_index.simulations | 173 |
| abstract_inverted_index.validation. | 153 |
| abstract_inverted_index.calculation, | 157 |
| abstract_inverted_index.contribution | 180 |
| abstract_inverted_index.experimental | 152, 244 |
| abstract_inverted_index.interactions | 203 |
| abstract_inverted_index.localization | 126, 237 |
| abstract_inverted_index.restrictions | 76 |
| abstract_inverted_index.virus‐like | 61 |
| abstract_inverted_index.computational | 149, 242 |
| abstract_inverted_index.demonstrating | 227 |
| abstract_inverted_index.(MM‐GB/PBSA) | 168 |
| abstract_inverted_index.alpha‐helical | 255, 272 |
| abstract_inverted_index.indistinguishable | 69 |
| abstract_inverted_index.lipid‐enveloped | 7 |
| abstract_inverted_index.mechanics‐based | 161 |
| abstract_inverted_index.saturation/alanine | 155 |
| abstract_inverted_index.Poisson‐Boltzmann | 165 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5078195240, https://openalex.org/A5071186045, https://openalex.org/A5029114040 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I107639228, https://openalex.org/I19700959, https://openalex.org/I219193219 |
| citation_normalized_percentile.value | 0.88809006 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |