Computer model-based injury prediction and evaluation of lung function in mice with acute and ventilator-induced lung injuries Article Swipe
Edward M. Kaye
,
Alexander Sosa
,
K Warner
,
David J. Albers
,
Peter D. Sottile
,
Bradford J. Smith
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1152/ajplung.00248.2025
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1152/ajplung.00248.2025
Computer model-based analysis of lung function in healthy and lung-injured mice showed that model compliance factor (C F ) characteristics were sensitive measures of acute lung injury and ventilator-induced lung injury (VILI) severity. The [Formula: see text] Area, calculated from C F and pressures from minutes 5–15 of ventilation, was a stronger predictor of VILI measured 4 h later than the driving pressure or mechanical power, suggesting potential utility for monitoring ventilation safety and guiding ventilator adjustments to reduce VILI.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1152/ajplung.00248.2025
- OA Status
- hybrid
- References
- 57
- OpenAlex ID
- https://openalex.org/W4414575459
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- DOI
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https://doi.org/10.1152/ajplung.00248.2025Digital Object Identifier
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Computer model-based injury prediction and evaluation of lung function in mice with acute and ventilator-induced lung injuriesWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-09-28Full publication date if available
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Edward M. Kaye, Alexander Sosa, K Warner, David J. Albers, Peter D. Sottile, Bradford J. SmithList of authors in order
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https://doi.org/10.1152/ajplung.00248.2025Publisher landing page
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://doi.org/10.1152/ajplung.00248.2025Direct OA link when available
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0Total citation count in OpenAlex
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57Number of works referenced by this work
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