Conducting Polymer‐ECM Scaffolds for Human Neuronal Cell Differentiation Article Swipe
Chiara Barberio
,
Janire Sáez
,
Aimee Withers
,
Malavika Nair
,
Francesco Tamagnini
,
Róisı́n M. Owens
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/adhm.202200941
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/adhm.202200941
3D cell culture formats more closely resemble tissue architecture complexity than 2D systems, which are lacking most of the cell–cell and cell–microenvironment interactions of the in vivo milieu. Scaffold‐based systems integrating natural biomaterials are extensively employed in tissue engineering to improve cell survival and outgrowth, by providing the chemical and physical cues of the natural extracellular matrix (ECM). Using the freeze–drying technique, porous 3D composite scaffolds consisting of poly(3,4‐ethylene‐dioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS), containing ECM components (i.e., collagen, hyaluronic acid, and laminin) are engineered for hosting neuronal cells. The resulting scaffolds exhibit a highly porous microstructure and good conductivity, determined by scanning electron microscopy and electrochemical impedance spectroscopy, respectively. These supports boast excellent mechanical stability and water uptake capacity, making them ideal candidates for cell infiltration. SH‐SY5Y human neuroblastoma cells show enhanced cell survival and proliferation in the presence of ECM compared to PEDOT:PSS alone. Whole‐cell patch‐clamp recordings acquired from differentiated SHSY5Y cells in the scaffolds demonstrate that ECM constituents promote neuronal differentiation in situ. These findings reinforce the usability of 3D conducting supports as engineered highly biomimetic and functional in vitro tissue‐like platforms for drug or disease modeling.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/adhm.202200941
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.202200941
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4288707727Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/adhm.202200941Digital Object Identifier
- Title
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Conducting Polymer‐ECM Scaffolds for Human Neuronal Cell DifferentiationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-07-29Full publication date if available
- Authors
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Chiara Barberio, Janire Sáez, Aimee Withers, Malavika Nair, Francesco Tamagnini, Róisı́n M. OwensList of authors in order
- Landing page
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https://doi.org/10.1002/adhm.202200941Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.202200941Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adhm.202200941Direct OA link when available
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Materials science, Extracellular matrix, 3D cell culture, Tissue engineering, Scaffold, Nanotechnology, Biomedical engineering, Cell, Cell biology, Chemistry, Biochemistry, Biology, MedicineTop concepts (fields/topics) attached by OpenAlex
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27Total citation count in OpenAlex
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2025: 10, 2024: 9, 2023: 6, 2022: 2Per-year citation counts (last 5 years)
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88Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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