Connection Between Chromosomal Location and Function of CtrA Phosphorelay Genes in Alphaproteobacteria Article Swipe
Jürgen Tomasch
,
Sonja Koppenhöfer
,
Andrew S. Lang
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2021.662907
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3389/fmicb.2021.662907
Most bacterial chromosomes are circular, with replication starting at one origin ( ori ) and proceeding on both replichores toward the terminus ( ter ). Several studies have shown that the location of genes relative to ori and ter can have profound effects on regulatory networks and physiological processes. The CtrA phosphorelay is a gene regulatory system conserved in most alphaproteobacteria. It was first discovered in Caulobacter crescentus where it controls replication and division into a stalked and a motile cell in coordination with other factors. The locations of the ctrA gene and targets of this response regulator on the chromosome affect their expression through replication-induced DNA hemi-methylation and specific positioning along a CtrA activity gradient in the dividing cell, respectively. Here we asked to what extent the location of CtrA regulatory network genes might be conserved in the alphaproteobacteria. We determined the locations of the CtrA phosphorelay and associated genes in closed genomes with unambiguously identifiable ori from members of five alphaproteobacterial orders. The location of the phosphorelay genes was the least conserved in the Rhodospirillales followed by the Sphingomonadales. In the Rhizobiales a trend toward certain chromosomal positions could be observed. Compared to the other orders, the CtrA phosphorelay genes were conserved closer to ori in the Caulobacterales. In contrast, the genes were highly conserved closer to ter in the Rhodobacterales. Our data suggest selection pressure results in differential positioning of CtrA phosphorelay and associated genes in alphaproteobacteria, particularly in the orders Rhodobacterales, Caulobacterales and Rhizobiales that is worth deeper investigation.
Related Topics
Concepts
Alphaproteobacteria
Biology
Caulobacter crescentus
Gene
Genetics
Cell division
Cell cycle
Cell
16S ribosomal RNA
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmicb.2021.662907
- https://www.frontiersin.org/articles/10.3389/fmicb.2021.662907/pdf
- OA Status
- gold
- Cited By
- 13
- References
- 67
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3157421782
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3157421782Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmicb.2021.662907Digital Object Identifier
- Title
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Connection Between Chromosomal Location and Function of CtrA Phosphorelay Genes in AlphaproteobacteriaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-04-29Full publication date if available
- Authors
-
Jürgen Tomasch, Sonja Koppenhöfer, Andrew S. LangList of authors in order
- Landing page
-
https://doi.org/10.3389/fmicb.2021.662907Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fmicb.2021.662907/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fmicb.2021.662907/pdfDirect OA link when available
- Concepts
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Alphaproteobacteria, Biology, Caulobacter crescentus, Gene, Genetics, Cell division, Cell cycle, Cell, 16S ribosomal RNATop concepts (fields/topics) attached by OpenAlex
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13Total citation count in OpenAlex
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2025: 3, 2024: 5, 2023: 2, 2022: 3Per-year citation counts (last 5 years)
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67Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| primary_location.pdf_url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.662907/pdf |
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| primary_location.raw_source_name | Frontiers in Microbiology |
| primary_location.landing_page_url | https://doi.org/10.3389/fmicb.2021.662907 |
| publication_date | 2021-04-29 |
| publication_year | 2021 |
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