Constant distance mode mass spectrometry imaging with a confocal sensor Article Swipe

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Tommy Zhang , Ryan T. Hilger , Lihua Jiang , Julia Laskin ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.26434/chemrxiv-2025-g3g27

Mass spectrometry imaging in constant distance mode is critical for analyzing samples with complex topography, achiev-ing high spatial resolution, and a robust imaging platform. Variations in sample height during an imaging experiment can cause signal instability, regardless of the ionization technique employed. In this work, we present the use of a confocal distance sensor for non-contact, real-time control of the sample height in MSI experiments. The confocal sensor offers sub-micron distance resolution and compatibility with a wide variety of surface optical properties. Although we demon-strate the performance of the sensor for constant distance mode nanospray desorption electrospray ionization (nano-DESI) experiments, the sensor is expected to be compatible with other MSI techniques, making it a versatile solution for challenging MSI applications.

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Confocal Mass spectrometry Desorption electrospray ionization Mass spectrometry imaging Chemistry Analytical Chemistry (journal) Ionization Optics Materials science Physics Thermal ionization mass spectrometry Chromatography Ion Organic chemistry

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Type: preprint
Language: en
Landing Page: https://doi.org/10.26434/chemrxiv-2025-g3g27
PDF: https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/685037cf3ba0887c33e1021d/original/constant-distance-mode-mass-spectrometry-imaging-with-a-confocal-sensor.pdf
OA Status: gold
Cited By: 1
References: 34
Related Works: 10
OpenAlex ID: https://openalex.org/W4411457121

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DOI: https://doi.org/10.26434/chemrxiv-2025-g3g27

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Title: Constant distance mode mass spectrometry imaging with a confocal sensor

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Type: preprint

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Language: en

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Publication year: 2025

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Publication date: 2025-06-19

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Authors: Tommy Zhang, Ryan T. Hilger, Lihua Jiang, Julia Laskin

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Landing page: https://doi.org/10.26434/chemrxiv-2025-g3g27

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PDF URL: https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/685037cf3ba0887c33e1021d/original/constant-distance-mode-mass-spectrometry-imaging-with-a-confocal-sensor.pdf

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Concepts: Confocal, Mass spectrometry, Desorption electrospray ionization, Mass spectrometry imaging, Chemistry, Analytical Chemistry (journal), Ionization, Optics, Materials science, Physics, Thermal ionization mass spectrometry, Chromatography, Ion, Organic chemistry

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Cited by: 1

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