Construction of Multiplexed Assays on Single Anisotropic Particles Using Microfluidics Article Swipe
Zengnan Wu
,
Yajing Zheng
,
Ling Lin
,
Gaowa Xing
,
Tianze Xie
,
Jiaxu Lin
,
Xiaorui Wang
,
Jin‐Ming Lin
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acscentsci.4c02009
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acscentsci.4c02009
Considerable efforts have been made to develop microscale multiplexing strategies. However, challenges remain due to the difficulty in deploying functional objects and decoding high-density signals on anisotropic microcarriers. Here, we report a microfluidic method to fabricate architecture-marked anisotropic particles for performing designable multiplexed assays in a label-free manner. By controlling fluid assembly and rapid in-air cross-linking, the particles are endowed with multiple functional regions and a unique architecture identifier. The marked architecture enables an addressing mechanism that allows the profiling of embedded label-free objects by mapping a well-defined reference architecture onto the target particle. By loading analytes of interest, such as molecular probes or cells, we showed the potential of these structurally flexible particles for detecting microRNAs and studying cell interactions. The architecture-marked particles represent a new approach for single-entity assays and can be the basis for exploring more advanced microscale multiplexed applications.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acscentsci.4c02009
- OA Status
- diamond
- References
- 57
- Related Works
- 10
- OpenAlex ID
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https://openalex.org/W4406399845Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acscentsci.4c02009Digital Object Identifier
- Title
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Construction of Multiplexed Assays on Single Anisotropic Particles Using MicrofluidicsWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
- Publication date
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2025-01-15Full publication date if available
- Authors
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Zengnan Wu, Yajing Zheng, Ling Lin, Gaowa Xing, Tianze Xie, Jiaxu Lin, Xiaorui Wang, Jin‐Ming LinList of authors in order
- Landing page
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https://doi.org/10.1021/acscentsci.4c02009Publisher landing page
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
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https://doi.org/10.1021/acscentsci.4c02009Direct OA link when available
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Microscale chemistry, Multiplexing, Microfluidics, Computer science, Nanotechnology, Biological system, Materials science, Biology, Telecommunications, Mathematics, Mathematics educationTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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