Continuous injection of high-dose lipopolysaccharide modulates microglia polarization via TREM2 to alter the status of septic mice Article Swipe
Zhiyun Qiu
,
Huilin Wang
,
Mengdi Qu
,
Shuainan Zhu
,
Hao Zhang
,
Qingwu Liao
,
Changhong Miao
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2064325/v1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-2064325/v1
Background Neuroinflammation of the central nervous system (CNS) is a prevalent syndrome of brain dysfunction secondary to severe sepsis and is regulated by microglia. Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is known to have protective functions, which modulates microglia polarization to M2 type to reduce inflammatory responses and thereby improve cognition. Methods We examined the effect of TREM2 on the polarization state of microglia during the onset of neuroinflammation. After one week of lipopolysaccharide consecutive injection, immunofluorescence (IF) assays, hematoxylin-eosin (HE), electron microscopy and western blotting were used to visualize hippocampal sections in C57BL/6 mice to assess TREM2 release. In addition, microglia polarization was analyzed by Quantitative RT-PCR. Result Continuous injection of LPS for 7 days improved systemic inflammation and behavioral cognitive dysfunction in septic mice. Serial injection of LPS for 7 days attenuated neuroinflammation in septic mice. LPS could reduce the expression of TREM2, however IFN-β enhanced TREM2 expression. TREM2 regulated the conversion of the microglial M1 phenotype to M2 phenotype. Conclusion The aim of this study was to further investigate the interconnection between microglia polarization and TREM2 in the CNS. All evidence supports our hypothesis that IFN-β can modulate TREM2 expression to alter the polarization state of microglia and thereby reduce central neuroinflammation induced by sequential LPS injections. Trem2 can be used as a new target for neuroinflammation treatment.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-2064325/v1
- https://www.researchsquare.com/article/rs-2064325/latest.pdf
- OA Status
- green
- References
- 27
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4295997683
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4295997683Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-2064325/v1Digital Object Identifier
- Title
-
Continuous injection of high-dose lipopolysaccharide modulates microglia polarization via TREM2 to alter the status of septic miceWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-09-16Full publication date if available
- Authors
-
Zhiyun Qiu, Huilin Wang, Mengdi Qu, Shuainan Zhu, Hao Zhang, Qingwu Liao, Changhong MiaoList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-2064325/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-2064325/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-2064325/latest.pdfDirect OA link when available
- Concepts
-
Neuroinflammation, Microglia, TREM2, Lipopolysaccharide, Inflammation, Immunology, MedicineTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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27Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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