arXiv (Cornell University)
Contrastive Integrated Gradients: A Feature Attribution-Based Method for Explaining Whole Slide Image Classification
November 2025 • Anh Vu, Tuan L. Vo, Ngoc Bui, Akash Awasthi, Huy Q. Vo, Thanh-Huy Nguyen, Zhu Han, Chandra Mohan
Interpretability is essential in Whole Slide Image (WSI) analysis for computational pathology, where understanding model predictions helps build trust in AI-assisted diagnostics. While Integrated Gradients (IG) and related attribution methods have shown promise, applying them directly to WSIs introduces challenges due to their high-resolution nature. These methods capture model decision patterns but may overlook class-discriminative signals that are crucial for distinguishing between tumor subtypes. In this work, …