Contribution of IL ‐12A and IL ‐12B Polymorphisms to Chlamydia trachomatis‐Specific Cell‐Mediated Immune Responses
Article Swipe
Hanna Öhman
,
Angels Natividad
,
Robin L. Bailey
,
Jiannis Ragoussis
,
Lawrence L. Johnson
,
Aila Tiitinen
,
Mervi Halttunen
,
Jorma Paavonen
,
Heljä‐Marja Surcel
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1111/sji.12264
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1111/sji.12264
Inherited variance in the IL ‐12B gene is associated with susceptibility to Chlamydia trachomatis ‐induced tubal factor infertility and disease severity. In this study, our aim was to discover how polymorphisms in IL ‐12‐coding genes influence C. trachomatis ‐induced immune responses and IL ‐12 production. The study population consisted of 240 women. IL ‐12A and IL ‐12B single nucleotide polymorphisms ( SNP s) were determined from isolated DNA using the Sequenom system with matrix‐assisted laser desorption/ionization time‐of‐flight ( MALDI ‐ TOF ) mass spectrometry. We studied lymphocyte proliferative ( LP ) responses to C. trachomatis strains E and F elementary bodies ( EB s) and recombinant chlamydial heat‐shock protein 60 ( CHSP 60) antigen. IL ‐12p40 and IL ‐12p70 levels were measured using the BD Flex Set method. We found a statistically significant association between the C. trachomatis EB antigen‐specific LP response and the rs2853694 SNP ( P = 0.02). Our study demonstrates that the IL ‐12 cytokine family is involved in C. trachomatis ‐specific immune responses. Moreover, C. trachomatis ‐induced IL ‐12 production and the IL ‐12B rs2853694 SNP partially explain individual variation in the C. trachomatis LP response.
Related Topics
Concepts
Chlamydia trachomatis
Single-nucleotide polymorphism
Immune system
Biology
Immunology
Antigen
SNP
Population
Genotype
Gene
Genetics
Medicine
Environmental health
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/sji.12264
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/sji.12264
- OA Status
- bronze
- Cited By
- 6
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2068440180
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2068440180Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/sji.12264Digital Object Identifier
- Title
-
Contribution of
IL ‐12A andIL ‐12B Polymorphisms to Chlamydia trachomatis‐Specific Cell‐Mediated Immune ResponsesWork title - Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-01-06Full publication date if available
- Authors
-
Hanna Öhman, Angels Natividad, Robin L. Bailey, Jiannis Ragoussis, Lawrence L. Johnson, Aila Tiitinen, Mervi Halttunen, Jorma Paavonen, Heljä‐Marja SurcelList of authors in order
- Landing page
-
https://doi.org/10.1111/sji.12264Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/sji.12264Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/sji.12264Direct OA link when available
- Concepts
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Chlamydia trachomatis, Single-nucleotide polymorphism, Immune system, Biology, Immunology, Antigen, SNP, Population, Genotype, Gene, Genetics, Medicine, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2022: 1, 2018: 1, 2017: 2, 2015: 1Per-year citation counts (last 5 years)
- References (count)
-
24Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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