Contribution of the Major ND10 Proteins PML, hDaxx and Sp100 to the Regulation of Human Cytomegalovirus Latency and Lytic Replication in the Monocytic Cell Line THP-1 Article Swipe
Nadine Wagenknecht
,
Nina Reuter
,
Myriam Scherer
,
Anna Reichel
,
Regina Müller
,
Thomas Stamminger
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.3390/v7062751
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.3390/v7062751
Promyelocytic leukemia nuclear bodies, also termed nuclear domain 10 (ND10), have emerged as nuclear protein accumulations mediating an intrinsic cellular defense against viral infections via chromatin-based mechanisms, however, their contribution to the control of herpesviral latency is still controversial. In this study, we utilized the monocytic cell line THP-1 as an in vitro latency model for human cytomegalovirus infection (HCMV). Characterization of THP-1 cells by immunofluorescence andWestern blot analysis confirmed the expression of all major ND10 components. THP-1 cells with a stable, individual knockdown of PML, hDaxx or Sp100 were generated. Importantly, depletion of the major ND10 proteins did not prevent the terminal cellular differentiation of THP-1 monocytes. After construction of a recombinant, endotheliotropic human cytomegalovirus expressing IE2-EYFP, we investigated whether the depletion of ND10 proteins affects the onset of viral IE gene expression. While after infection of differentiated, THP-1-derived macrophages as well as during differentiation-induced reactivation from latency an increase in the number of IE-expressing cells was readily detectable in the absence of the major ND10 proteins, no effect was observed in non-differentiated monocytes. We conclude that PML, hDaxx and Sp100 primarily act as cellular restriction factors during lytic HCMV replication and during the dynamic process of reactivation but do not serve as key determinants for the establishment of HCMV latency.
Related Topics
Concepts
Biology
Lytic cycle
Human cytomegalovirus
Promyelocytic leukemia protein
Cell biology
Cellular stress response
Cell culture
Nuclear protein
Virology
Transcription factor
Genetics
Virus
Gene
Fight-or-flight response
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/v7062751
- https://www.mdpi.com/1999-4915/7/6/2751/pdf?version=1433490576
- OA Status
- gold
- Cited By
- 67
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2111725944
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2111725944Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/v7062751Digital Object Identifier
- Title
-
Contribution of the Major ND10 Proteins PML, hDaxx and Sp100 to the Regulation of Human Cytomegalovirus Latency and Lytic Replication in the Monocytic Cell Line THP-1Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-06-05Full publication date if available
- Authors
-
Nadine Wagenknecht, Nina Reuter, Myriam Scherer, Anna Reichel, Regina Müller, Thomas StammingerList of authors in order
- Landing page
-
https://doi.org/10.3390/v7062751Publisher landing page
- PDF URL
-
https://www.mdpi.com/1999-4915/7/6/2751/pdf?version=1433490576Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1999-4915/7/6/2751/pdf?version=1433490576Direct OA link when available
- Concepts
-
Biology, Lytic cycle, Human cytomegalovirus, Promyelocytic leukemia protein, Cell biology, Cellular stress response, Cell culture, Nuclear protein, Virology, Transcription factor, Genetics, Virus, Gene, Fight-or-flight responseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
67Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 5, 2023: 8, 2022: 8, 2021: 6Per-year citation counts (last 5 years)
- References (count)
-
63Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.In | 39 |
| abstract_inverted_index.We | 175 |
| abstract_inverted_index.an | 17, 50, 149 |
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| abstract_inverted_index.act | 183 |
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| abstract_inverted_index.and | 180, 192 |
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| abstract_inverted_index.for | 55, 206 |
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| abstract_inverted_index.PML, | 85, 178 |
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| abstract_inverted_index.Sp100 | 88, 181 |
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| abstract_inverted_index.after | 135 |
| abstract_inverted_index.cells | 63, 78, 156 |
| abstract_inverted_index.hDaxx | 86, 179 |
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| abstract_inverted_index.their | 28 |
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| abstract_inverted_index.number | 153 |
| abstract_inverted_index.study, | 41 |
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| abstract_inverted_index.(HCMV). | 59 |
| abstract_inverted_index.(ND10), | 9 |
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| abstract_inverted_index.against | 21 |
| abstract_inverted_index.bodies, | 3 |
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| abstract_inverted_index.factors | 187 |
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| abstract_inverted_index.increase | 150 |
| abstract_inverted_index.latency. | 211 |
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| abstract_inverted_index.detectable | 159 |
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| abstract_inverted_index.establishment | 208 |
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| abstract_inverted_index.Characterization | 60 |
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| abstract_inverted_index.immunofluorescence | 65 |
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| citation_normalized_percentile.is_in_top_10_percent | True |