Control of Neuronal Survival and Development Using Conductive Diamond Article Swipe

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Diamond Materials science Nanotechnology Electrical conductor Substrate (aquarium) Neurite Extracellular matrix Bioelectronics Neuroscience Cell biology Biology Biosensor Biochemistry In vitro Composite material Ecology

Samira Falahatdoost , Yair D. J. Prawer , Danli Peng , Andre Chambers , Hualin Zhan , Leon Pope , Alastair Stacey , Arman Ahnood , Hassan N. Al Hashem , Sorel E. De León , David J. Garrett , Kate Fox , Michael B. Clark , Michael R. Ibbotson , Steven Prawer , Wei Tong ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1021/acsami.3c14680 · OA: W4390938162

This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuronal survival and neurite outgrowth and foster a more active, synchronized neuronal network. Whole transcriptome RNA sequencing reveals that diamond substrates improve cellular-substrate interaction by upregulating extracellular matrix and gap junction-related genes. Our findings underscore the potential of conductive diamond as a robust and biocompatible platform for noninvasive and effective neural tissue engineering.