Controllable mitochondrial aggregation and fusion by a programmable DNA binder Article Swipe
Longyi Zhu
,
Yi‐Ting Shen
,
Shengyuan Deng
,
Ying Wan
,
Jun Luo
,
Yan Su
,
Mingxu You
,
Chunhai Fan
,
Kewei Ren
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1595440/v1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1595440/v1
DNA nanodevices have been feasibly applied for various chemo-biological applications, but their functions as precise regulators of intracellular organelles are still limited. Here, we report a synthetic DNA binder that can artificially induce mitochondrial aggregation and fusion in living cells. The rationally designed DNA binder consists of a long DNA chain, which is grafted with multiple mitochondria-targeting modules. Our results indicated that the DNA binder-induced in situ self-assembly of mitochondria can be used to successfully repair ROS-stressed neuron cells. Meanwhile, this DNA binder design is highly programmable. Customized molecular switches can be easily implanted to further achieve stimuli-triggered mitochondrial aggregation and fusion inside living cells. We believe this new type of DNA regulator system will become a powerful chemo-biological tool for subcellular manipulation and precision therapy.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-1595440/v1
- https://www.researchsquare.com/article/rs-1595440/latest.pdf
- OA Status
- gold
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4306818307
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4306818307Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-1595440/v1Digital Object Identifier
- Title
-
Controllable mitochondrial aggregation and fusion by a programmable DNA binderWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-10-19Full publication date if available
- Authors
-
Longyi Zhu, Yi‐Ting Shen, Shengyuan Deng, Ying Wan, Jun Luo, Yan Su, Mingxu You, Chunhai Fan, Kewei RenList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-1595440/v1Publisher landing page
- PDF URL
-
https://www.researchsquare.com/article/rs-1595440/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-1595440/latest.pdfDirect OA link when available
- Concepts
-
Fusion, Mitochondrial DNA, mitochondrial fusion, DNA, Chemistry, Computer science, Computational biology, Biophysics, Nanotechnology, Materials science, Biology, Biochemistry, Philosophy, Gene, LinguisticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
29Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4306818307 |
|---|---|
| doi | https://doi.org/10.21203/rs.3.rs-1595440/v1 |
| ids.doi | https://doi.org/10.21203/rs.3.rs-1595440/v1 |
| ids.openalex | https://openalex.org/W4306818307 |
| fwci | 0.0 |
| type | preprint |
| title | Controllable mitochondrial aggregation and fusion by a programmable DNA binder |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10207 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9987999796867371 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Advanced biosensing and bioanalysis techniques |
| topics[1].id | https://openalex.org/T10521 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.991100013256073 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | RNA and protein synthesis mechanisms |
| topics[2].id | https://openalex.org/T10301 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9887999892234802 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Mitochondrial Function and Pathology |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C158525013 |
| concepts[0].level | 2 |
| concepts[0].score | 0.6398319005966187 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q2593739 |
| concepts[0].display_name | Fusion |
| concepts[1].id | https://openalex.org/C24586158 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6205757856369019 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q27075 |
| concepts[1].display_name | Mitochondrial DNA |
| concepts[2].id | https://openalex.org/C163950672 |
| concepts[2].level | 4 |
| concepts[2].score | 0.43029487133026123 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q14905375 |
| concepts[2].display_name | mitochondrial fusion |
| concepts[3].id | https://openalex.org/C552990157 |
| concepts[3].level | 2 |
| concepts[3].score | 0.42409563064575195 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7430 |
| concepts[3].display_name | DNA |
| concepts[4].id | https://openalex.org/C185592680 |
| concepts[4].level | 0 |
| concepts[4].score | 0.395969420671463 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[4].display_name | Chemistry |
| concepts[5].id | https://openalex.org/C41008148 |
| concepts[5].level | 0 |
| concepts[5].score | 0.3567578196525574 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[5].display_name | Computer science |
| concepts[6].id | https://openalex.org/C70721500 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3494724631309509 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[6].display_name | Computational biology |
| concepts[7].id | https://openalex.org/C12554922 |
| concepts[7].level | 1 |
| concepts[7].score | 0.33641940355300903 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7100 |
| concepts[7].display_name | Biophysics |
| concepts[8].id | https://openalex.org/C171250308 |
| concepts[8].level | 1 |
| concepts[8].score | 0.3302311301231384 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11468 |
| concepts[8].display_name | Nanotechnology |
| concepts[9].id | https://openalex.org/C192562407 |
| concepts[9].level | 0 |
| concepts[9].score | 0.24557849764823914 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[9].display_name | Materials science |
| concepts[10].id | https://openalex.org/C86803240 |
| concepts[10].level | 0 |
| concepts[10].score | 0.22666829824447632 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[10].display_name | Biology |
| concepts[11].id | https://openalex.org/C55493867 |
| concepts[11].level | 1 |
| concepts[11].score | 0.15854665637016296 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[11].display_name | Biochemistry |
| concepts[12].id | https://openalex.org/C138885662 |
| concepts[12].level | 0 |
| concepts[12].score | 0.06508404016494751 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q5891 |
| concepts[12].display_name | Philosophy |
| concepts[13].id | https://openalex.org/C104317684 |
| concepts[13].level | 2 |
| concepts[13].score | 0.061536580324172974 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[13].display_name | Gene |
| concepts[14].id | https://openalex.org/C41895202 |
| concepts[14].level | 1 |
| concepts[14].score | 0.0 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q8162 |
| concepts[14].display_name | Linguistics |
| keywords[0].id | https://openalex.org/keywords/fusion |
| keywords[0].score | 0.6398319005966187 |
| keywords[0].display_name | Fusion |
| keywords[1].id | https://openalex.org/keywords/mitochondrial-dna |
| keywords[1].score | 0.6205757856369019 |
| keywords[1].display_name | Mitochondrial DNA |
| keywords[2].id | https://openalex.org/keywords/mitochondrial-fusion |
| keywords[2].score | 0.43029487133026123 |
| keywords[2].display_name | mitochondrial fusion |
| keywords[3].id | https://openalex.org/keywords/dna |
| keywords[3].score | 0.42409563064575195 |
| keywords[3].display_name | DNA |
| keywords[4].id | https://openalex.org/keywords/chemistry |
| keywords[4].score | 0.395969420671463 |
| keywords[4].display_name | Chemistry |
| keywords[5].id | https://openalex.org/keywords/computer-science |
| keywords[5].score | 0.3567578196525574 |
| keywords[5].display_name | Computer science |
| keywords[6].id | https://openalex.org/keywords/computational-biology |
| keywords[6].score | 0.3494724631309509 |
| keywords[6].display_name | Computational biology |
| keywords[7].id | https://openalex.org/keywords/biophysics |
| keywords[7].score | 0.33641940355300903 |
| keywords[7].display_name | Biophysics |
| keywords[8].id | https://openalex.org/keywords/nanotechnology |
| keywords[8].score | 0.3302311301231384 |
| keywords[8].display_name | Nanotechnology |
| keywords[9].id | https://openalex.org/keywords/materials-science |
| keywords[9].score | 0.24557849764823914 |
| keywords[9].display_name | Materials science |
| keywords[10].id | https://openalex.org/keywords/biology |
| keywords[10].score | 0.22666829824447632 |
| keywords[10].display_name | Biology |
| keywords[11].id | https://openalex.org/keywords/biochemistry |
| keywords[11].score | 0.15854665637016296 |
| keywords[11].display_name | Biochemistry |
| keywords[12].id | https://openalex.org/keywords/philosophy |
| keywords[12].score | 0.06508404016494751 |
| keywords[12].display_name | Philosophy |
| keywords[13].id | https://openalex.org/keywords/gene |
| keywords[13].score | 0.061536580324172974 |
| keywords[13].display_name | Gene |
| language | en |
| locations[0].id | doi:10.21203/rs.3.rs-1595440/v1 |
| locations[0].is_oa | True |
| locations[0].source | |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.researchsquare.com/article/rs-1595440/latest.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.21203/rs.3.rs-1595440/v1 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5009445601 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-0898-4804 |
| authorships[0].author.display_name | Longyi Zhu |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I36399199 |
| authorships[0].affiliations[0].raw_affiliation_string | Nanjing University of Science and Technology |
| authorships[0].institutions[0].id | https://openalex.org/I36399199 |
| authorships[0].institutions[0].ror | https://ror.org/00xp9wg62 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I36399199 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Nanjing University of Science and Technology |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Longyi Zhu |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Nanjing University of Science and Technology |
| authorships[1].author.id | https://openalex.org/A5016275823 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-1167-5535 |
| authorships[1].author.display_name | Yi‐Ting Shen |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I36399199 |
| authorships[1].affiliations[0].raw_affiliation_string | Nanjing University of Science and Technology |
| authorships[1].institutions[0].id | https://openalex.org/I36399199 |
| authorships[1].institutions[0].ror | https://ror.org/00xp9wg62 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I36399199 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Nanjing University of Science and Technology |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Yiting Shen |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Nanjing University of Science and Technology |
| authorships[2].author.id | https://openalex.org/A5027571145 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6382-0976 |
| authorships[2].author.display_name | Shengyuan Deng |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I36399199 |
| authorships[2].affiliations[0].raw_affiliation_string | Nanjing University of Science and Technology |
| authorships[2].institutions[0].id | https://openalex.org/I36399199 |
| authorships[2].institutions[0].ror | https://ror.org/00xp9wg62 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I36399199 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Nanjing University of Science and Technology |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Shengyuan Deng |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Nanjing University of Science and Technology |
| authorships[3].author.id | https://openalex.org/A5077959613 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-5909-2892 |
| authorships[3].author.display_name | Ying Wan |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I130769515 |
| authorships[3].affiliations[0].raw_affiliation_string | Pennsylvania State University |
| authorships[3].institutions[0].id | https://openalex.org/I130769515 |
| authorships[3].institutions[0].ror | https://ror.org/04p491231 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I130769515 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Pennsylvania State University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Ying Wan |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Pennsylvania State University |
| authorships[4].author.id | https://openalex.org/A5022408966 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-8093-5345 |
| authorships[4].author.display_name | Jun Luo |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I36399199 |
| authorships[4].affiliations[0].raw_affiliation_string | Nanjing University of Science and Technology |
| authorships[4].institutions[0].id | https://openalex.org/I36399199 |
| authorships[4].institutions[0].ror | https://ror.org/00xp9wg62 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I36399199 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Nanjing University of Science and Technology |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Jun Luo |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Nanjing University of Science and Technology |
| authorships[5].author.id | https://openalex.org/A5029830698 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-9295-348X |
| authorships[5].author.display_name | Yan Su |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I24603500 |
| authorships[5].affiliations[0].raw_affiliation_string | Nanjing University of Science and Technology Mingxu You University of Massachusetts Amherst |
| authorships[5].institutions[0].id | https://openalex.org/I24603500 |
| authorships[5].institutions[0].ror | https://ror.org/0072zz521 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I24603500 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | University of Massachusetts Amherst |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Yan Su |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Nanjing University of Science and Technology Mingxu You University of Massachusetts Amherst |
| authorships[6].author.id | https://openalex.org/A5005394149 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-3293-9760 |
| authorships[6].author.display_name | Mingxu You |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I24603500 |
| authorships[6].affiliations[0].raw_affiliation_string | University of Massachusetts Amherst |
| authorships[6].institutions[0].id | https://openalex.org/I24603500 |
| authorships[6].institutions[0].ror | https://ror.org/0072zz521 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I24603500 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | University of Massachusetts Amherst |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Mingxu You |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | University of Massachusetts Amherst |
| authorships[7].author.id | https://openalex.org/A5006228310 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-7171-7338 |
| authorships[7].author.display_name | Chunhai Fan |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I183067930 |
| authorships[7].affiliations[0].raw_affiliation_string | Shanghai Jiao Tong University |
| authorships[7].institutions[0].id | https://openalex.org/I183067930 |
| authorships[7].institutions[0].ror | https://ror.org/0220qvk04 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I183067930 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Shanghai Jiao Tong University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Chunhai Fan |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Shanghai Jiao Tong University |
| authorships[8].author.id | https://openalex.org/A5101571904 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-7115-6377 |
| authorships[8].author.display_name | Kewei Ren |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I36399199 |
| authorships[8].affiliations[0].raw_affiliation_string | Nanjing University of Science and Technology |
| authorships[8].institutions[0].id | https://openalex.org/I36399199 |
| authorships[8].institutions[0].ror | https://ror.org/00xp9wg62 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I36399199 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Nanjing University of Science and Technology |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Kewei Ren |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | Nanjing University of Science and Technology |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.researchsquare.com/article/rs-1595440/latest.pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Controllable mitochondrial aggregation and fusion by a programmable DNA binder |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10207 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9987999796867371 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Advanced biosensing and bioanalysis techniques |
| related_works | https://openalex.org/W2326369733, https://openalex.org/W4308441232, https://openalex.org/W2567787466, https://openalex.org/W2022430805, https://openalex.org/W2068493848, https://openalex.org/W2433011597, https://openalex.org/W2058866756, https://openalex.org/W3081196248, https://openalex.org/W2087856402, https://openalex.org/W2101111866 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.21203/rs.3.rs-1595440/v1 |
| best_oa_location.is_oa | True |
| best_oa_location.source | |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.researchsquare.com/article/rs-1595440/latest.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-1595440/v1 |
| primary_location.id | doi:10.21203/rs.3.rs-1595440/v1 |
| primary_location.is_oa | True |
| primary_location.source | |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.researchsquare.com/article/rs-1595440/latest.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-1595440/v1 |
| publication_date | 2022-10-19 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W6758490301, https://openalex.org/W2937519508, https://openalex.org/W6755355277, https://openalex.org/W2603334614, https://openalex.org/W3197121076, https://openalex.org/W2131408058, https://openalex.org/W2980670178, https://openalex.org/W2103302421, https://openalex.org/W2063893203, https://openalex.org/W3111589283, https://openalex.org/W3157599532, https://openalex.org/W2206033595, https://openalex.org/W2082114067, https://openalex.org/W4246248333, https://openalex.org/W2259212906, https://openalex.org/W3011686678, https://openalex.org/W2949430028, https://openalex.org/W2329896225, https://openalex.org/W2068664917, https://openalex.org/W3139040162, https://openalex.org/W2172133399, https://openalex.org/W3095983020, https://openalex.org/W2116829159, https://openalex.org/W3161035177, https://openalex.org/W3081100275, https://openalex.org/W2898636715, https://openalex.org/W3213915304, https://openalex.org/W4240304164, https://openalex.org/W2067175450 |
| referenced_works_count | 29 |
| abstract_inverted_index.a | 26, 48, 117 |
| abstract_inverted_index.We | 106 |
| abstract_inverted_index.as | 14 |
| abstract_inverted_index.be | 72, 92 |
| abstract_inverted_index.in | 38, 66 |
| abstract_inverted_index.is | 53, 85 |
| abstract_inverted_index.of | 17, 47, 69, 111 |
| abstract_inverted_index.to | 74, 95 |
| abstract_inverted_index.we | 24 |
| abstract_inverted_index.DNA | 1, 28, 44, 50, 64, 82, 112 |
| abstract_inverted_index.Our | 59 |
| abstract_inverted_index.The | 41 |
| abstract_inverted_index.and | 36, 101, 124 |
| abstract_inverted_index.are | 20 |
| abstract_inverted_index.but | 11 |
| abstract_inverted_index.can | 31, 71, 91 |
| abstract_inverted_index.for | 7, 121 |
| abstract_inverted_index.new | 109 |
| abstract_inverted_index.the | 63 |
| abstract_inverted_index.been | 4 |
| abstract_inverted_index.have | 3 |
| abstract_inverted_index.long | 49 |
| abstract_inverted_index.situ | 67 |
| abstract_inverted_index.that | 30, 62 |
| abstract_inverted_index.this | 81, 108 |
| abstract_inverted_index.tool | 120 |
| abstract_inverted_index.type | 110 |
| abstract_inverted_index.used | 73 |
| abstract_inverted_index.will | 115 |
| abstract_inverted_index.with | 55 |
| abstract_inverted_index.Here, | 23 |
| abstract_inverted_index.still | 21 |
| abstract_inverted_index.their | 12 |
| abstract_inverted_index.which | 52 |
| abstract_inverted_index.become | 116 |
| abstract_inverted_index.binder | 29, 45, 83 |
| abstract_inverted_index.cells. | 40, 79, 105 |
| abstract_inverted_index.chain, | 51 |
| abstract_inverted_index.design | 84 |
| abstract_inverted_index.easily | 93 |
| abstract_inverted_index.fusion | 37, 102 |
| abstract_inverted_index.highly | 86 |
| abstract_inverted_index.induce | 33 |
| abstract_inverted_index.inside | 103 |
| abstract_inverted_index.living | 39, 104 |
| abstract_inverted_index.neuron | 78 |
| abstract_inverted_index.repair | 76 |
| abstract_inverted_index.report | 25 |
| abstract_inverted_index.system | 114 |
| abstract_inverted_index.achieve | 97 |
| abstract_inverted_index.applied | 6 |
| abstract_inverted_index.believe | 107 |
| abstract_inverted_index.further | 96 |
| abstract_inverted_index.grafted | 54 |
| abstract_inverted_index.precise | 15 |
| abstract_inverted_index.results | 60 |
| abstract_inverted_index.various | 8 |
| abstract_inverted_index.consists | 46 |
| abstract_inverted_index.designed | 43 |
| abstract_inverted_index.feasibly | 5 |
| abstract_inverted_index.limited. | 22 |
| abstract_inverted_index.modules. | 58 |
| abstract_inverted_index.multiple | 56 |
| abstract_inverted_index.powerful | 118 |
| abstract_inverted_index.switches | 90 |
| abstract_inverted_index.therapy. | 126 |
| abstract_inverted_index.functions | 13 |
| abstract_inverted_index.implanted | 94 |
| abstract_inverted_index.indicated | 61 |
| abstract_inverted_index.molecular | 89 |
| abstract_inverted_index.precision | 125 |
| abstract_inverted_index.regulator | 113 |
| abstract_inverted_index.synthetic | 27 |
| abstract_inverted_index.Customized | 88 |
| abstract_inverted_index.Meanwhile, | 80 |
| abstract_inverted_index.organelles | 19 |
| abstract_inverted_index.rationally | 42 |
| abstract_inverted_index.regulators | 16 |
| abstract_inverted_index.aggregation | 35, 100 |
| abstract_inverted_index.nanodevices | 2 |
| abstract_inverted_index.subcellular | 122 |
| abstract_inverted_index.ROS-stressed | 77 |
| abstract_inverted_index.artificially | 32 |
| abstract_inverted_index.manipulation | 123 |
| abstract_inverted_index.mitochondria | 70 |
| abstract_inverted_index.successfully | 75 |
| abstract_inverted_index.applications, | 10 |
| abstract_inverted_index.intracellular | 18 |
| abstract_inverted_index.mitochondrial | 34, 99 |
| abstract_inverted_index.programmable. | 87 |
| abstract_inverted_index.self-assembly | 68 |
| abstract_inverted_index.binder-induced | 65 |
| abstract_inverted_index.chemo-biological | 9, 119 |
| abstract_inverted_index.stimuli-triggered | 98 |
| abstract_inverted_index.mitochondria-targeting | 57 |
| abstract_inverted_index.<title>Abstract</title> | 0 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5101571904 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I36399199 |
| citation_normalized_percentile.value | 0.12683817 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |