Controlling fibroblast adhesion and proliferation by 1D Al ₂ O ₃ nanostructures Article Swipe

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Fibroblast Nanostructure Aluminium Materials science Focal adhesion Biophysics Cell adhesion Nanotechnology Adhesion Cell Chemistry Composite material Biology Biochemistry In vitro

Oral Cenk Aktas , Wolfgang Metzger , Lisa Mees , Marina Miro Martinez , Ayman Haidar , Martin Oberringer , Gunther Wennemuth , Norbert Pütz , Muhammad Zubair Ghori , Tim Pohlemann , Michael Veith ·

YOU? · · 2019 · Open Access · · DOI: https://doi.org/10.1049/iet-nbt.2018.5088 · OA: W2914709762

The fibrotic encapsulation, which is mainly accompanied by an excessive proliferation of fibroblasts, is an undesired phenomenon after the implantation of various medical devices. Beside the surface chemistry, the topography plays also a major role in the fibroblast–surface interaction. In the present study, one‐dimensional aluminium oxide (1D Al 2 O 3 ) nanostructures with different distribution densities were prepared to reveal the response of human fibroblasts to the surface topography. The cell size, the cell number and the ability to form well‐defined actin fibres and focal adhesions were significantly impaired with increasing distribution density of the 1D Al 2 O 3 nanostructures on the substratum.