Convergent Approaches and Biological Activity of C1 and/or C3 Mono or Diamino Derivatives of 1α,25‐Dihydroxy‐19‐nor‐vitamin D3. Key Enzymatic Desymmetrization of A‐Ring Synthon Precursor Article Swipe
Tania González‐García
,
Annemieke Verstuyf
,
Lieve Verlinden
,
Susana Fernández
,
Miguel Ferrero
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/adsc.202201158
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/adsc.202201158
Three novel 19‐ nor ‐1α,25‐dihydroxyvitamin D 3 derivatives modified at C1 and/or C3 with an amino group were synthesized to study the influence of the substitution of one or both hydroxyl groups of A‐ring by amino groups on the affinity for vitamin D receptor (VDR) and vitamin D binding protein (hDBP), and also on the antiproliferative activity. The A‐ring precursors were prepared from cis , cis ‐1,3,5‐cyclohexanetriol applying a desymmetrization reaction of a prochiral 1,3‐diol catalyzed by Pseudomonas cepacia lipase as a key step. The structural elucidation of diastereoisomers were unambiguously assigned by NMR spectroscopy. magnified image
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/adsc.202201158
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adsc.202201158
- OA Status
- hybrid
- Cited By
- 2
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4313517525
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https://openalex.org/W4313517525Canonical identifier for this work in OpenAlex
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https://doi.org/10.1002/adsc.202201158Digital Object Identifier
- Title
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Convergent Approaches and Biological Activity of C1 and/or C3 Mono or Diamino Derivatives of 1α,25‐Dihydroxy‐19‐nor‐vitamin D3. Key Enzymatic Desymmetrization of A‐Ring Synthon PrecursorWork title
- Type
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articleOpenAlex work type
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-12-22Full publication date if available
- Authors
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Tania González‐García, Annemieke Verstuyf, Lieve Verlinden, Susana Fernández, Miguel FerreroList of authors in order
- Landing page
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https://doi.org/10.1002/adsc.202201158Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adsc.202201158Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/adsc.202201158Direct OA link when available
- Concepts
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Chemistry, Desymmetrization, Calcitriol receptor, Diastereomer, Stereochemistry, Biocatalysis, Ring (chemistry), Diol, Enzyme, Enantioselective synthesis, Catalysis, Organic chemistry, Biochemistry, Receptor, Reaction mechanismTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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41Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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