Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states Article Swipe
Joël Babdor
,
Ravi K. Patel
,
Brittany Davidson
,
Cecilia Noecker
,
Maha K. Rahim
,
Jordan E. Bisanz
,
Iliana Tenvooren
,
Diana M. Marquez
,
Lorena Espinar
,
Vrinda Johri
,
Elizabeth W. McCarthy
,
Avneet Shaheed
,
Christina Ekstrand
,
Allison M. Weakley
,
Feiqiao Brian Yu
,
Oliver Fiehn
,
Peter J. Turnbaugh
,
Alexis J. Combes
,
Gabriela K. Fragiadakis
,
Matthew H. Spitzer
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.11.27.625750
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.11.27.625750
Human immune systems are highly variable, with most variation attributable to non-genetic sources. The gut microbiome crucially shapes the immune system; however, its relationship with the baseline immune states of healthy humans remains incompletely understood. Therefore, we performed multi-omic profiling of 110 healthy participants through the ImmunoMicrobiome study. A factor-based integrative approach identified coordinated variation, revealing that the tonic interferon response was amongst the most variable immune features in healthy participants. Microbiome composition, pathways, and stool metabolites varied concomitantly with interferon response pathways. Distinct transcriptional programs involving inflammation and TGF-β in SIGLEC-1 high monocytes and CD69 high activated MAIT and NK cells were representative of these programs. Our study provides extensive data to examine the relationship between the immune states and microbiomes of healthy individuals at steady state, which paves the way for delineating inter-individual differences relevant for disease susceptibility and responses to therapy.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.11.27.625750
- OA Status
- green
- Cited By
- 1
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404949243
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4404949243Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2024.11.27.625750Digital Object Identifier
- Title
-
Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon statesWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-12-03Full publication date if available
- Authors
-
Joël Babdor, Ravi K. Patel, Brittany Davidson, Cecilia Noecker, Maha K. Rahim, Jordan E. Bisanz, Iliana Tenvooren, Diana M. Marquez, Lorena Espinar, Vrinda Johri, Elizabeth W. McCarthy, Avneet Shaheed, Christina Ekstrand, Allison M. Weakley, Feiqiao Brian Yu, Oliver Fiehn, Peter J. Turnbaugh, Alexis J. Combes, Gabriela K. Fragiadakis, Matthew H. SpitzerList of authors in order
- Landing page
-
https://doi.org/10.1101/2024.11.27.625750Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/11642739Direct OA link when available
- Concepts
-
Immune system, Microbiome, Biology, Interferon, Immunology, Genetic variation, Computational biology, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4404949243 |
|---|---|
| doi | https://doi.org/10.1101/2024.11.27.625750 |
| ids.doi | https://doi.org/10.1101/2024.11.27.625750 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/39677657 |
| ids.openalex | https://openalex.org/W4404949243 |
| fwci | 0.48024723 |
| type | preprint |
| title | Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10887 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9894000291824341 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Bioinformatics and Genomic Networks |
| topics[1].id | https://openalex.org/T10066 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9696000218391418 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Gut microbiota and health |
| topics[2].id | https://openalex.org/T10836 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9412000179290771 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Metabolomics and Mass Spectrometry Studies |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C8891405 |
| concepts[0].level | 2 |
| concepts[0].score | 0.8235068321228027 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[0].display_name | Immune system |
| concepts[1].id | https://openalex.org/C143121216 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7877492904663086 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1330402 |
| concepts[1].display_name | Microbiome |
| concepts[2].id | https://openalex.org/C86803240 |
| concepts[2].level | 0 |
| concepts[2].score | 0.6413589715957642 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[2].display_name | Biology |
| concepts[3].id | https://openalex.org/C2776178377 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6267394423484802 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q188269 |
| concepts[3].display_name | Interferon |
| concepts[4].id | https://openalex.org/C203014093 |
| concepts[4].level | 1 |
| concepts[4].score | 0.5011804103851318 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[4].display_name | Immunology |
| concepts[5].id | https://openalex.org/C68873052 |
| concepts[5].level | 3 |
| concepts[5].score | 0.41345635056495667 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q349856 |
| concepts[5].display_name | Genetic variation |
| concepts[6].id | https://openalex.org/C70721500 |
| concepts[6].level | 1 |
| concepts[6].score | 0.39692872762680054 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q177005 |
| concepts[6].display_name | Computational biology |
| concepts[7].id | https://openalex.org/C54355233 |
| concepts[7].level | 1 |
| concepts[7].score | 0.31973403692245483 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[7].display_name | Genetics |
| concepts[8].id | https://openalex.org/C104317684 |
| concepts[8].level | 2 |
| concepts[8].score | 0.19277387857437134 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[8].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/immune-system |
| keywords[0].score | 0.8235068321228027 |
| keywords[0].display_name | Immune system |
| keywords[1].id | https://openalex.org/keywords/microbiome |
| keywords[1].score | 0.7877492904663086 |
| keywords[1].display_name | Microbiome |
| keywords[2].id | https://openalex.org/keywords/biology |
| keywords[2].score | 0.6413589715957642 |
| keywords[2].display_name | Biology |
| keywords[3].id | https://openalex.org/keywords/interferon |
| keywords[3].score | 0.6267394423484802 |
| keywords[3].display_name | Interferon |
| keywords[4].id | https://openalex.org/keywords/immunology |
| keywords[4].score | 0.5011804103851318 |
| keywords[4].display_name | Immunology |
| keywords[5].id | https://openalex.org/keywords/genetic-variation |
| keywords[5].score | 0.41345635056495667 |
| keywords[5].display_name | Genetic variation |
| keywords[6].id | https://openalex.org/keywords/computational-biology |
| keywords[6].score | 0.39692872762680054 |
| keywords[6].display_name | Computational biology |
| keywords[7].id | https://openalex.org/keywords/genetics |
| keywords[7].score | 0.31973403692245483 |
| keywords[7].display_name | Genetics |
| keywords[8].id | https://openalex.org/keywords/gene |
| keywords[8].score | 0.19277387857437134 |
| keywords[8].display_name | Gene |
| language | en |
| locations[0].id | doi:10.1101/2024.11.27.625750 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2024.11.27.625750 |
| locations[1].id | pmid:39677657 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | bioRxiv : the preprint server for biology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/39677657 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11642739 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | bioRxiv |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11642739 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5031253566 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1696-5814 |
| authorships[0].author.display_name | Joël Babdor |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210125521, https://openalex.org/I79576946 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Systems Pharmacology and Translational Therapeutics, Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[0].affiliations[1].raw_affiliation_string | Bakar ImmunoX program, University of California, San Francisco, CA, USA |
| authorships[0].affiliations[2].institution_ids | https://openalex.org/I180670191 |
| authorships[0].affiliations[2].raw_affiliation_string | Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA |
| authorships[0].affiliations[3].institution_ids | https://openalex.org/I180670191 |
| authorships[0].affiliations[3].raw_affiliation_string | Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA |
| authorships[0].affiliations[4].institution_ids | https://openalex.org/I180670191, https://openalex.org/I4210167126 |
| authorships[0].affiliations[4].raw_affiliation_string | Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA |
| authorships[0].institutions[0].id | https://openalex.org/I4210125521 |
| authorships[0].institutions[0].ror | https://ror.org/02z3rcy16 |
| authorships[0].institutions[0].type | company |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210125521 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Translational Therapeutics (United States) |
| authorships[0].institutions[1].id | https://openalex.org/I4210167126 |
| authorships[0].institutions[1].ror | https://ror.org/05yndxy10 |
| authorships[0].institutions[1].type | facility |
| authorships[0].institutions[1].lineage | https://openalex.org/I180670191, https://openalex.org/I4210110664, https://openalex.org/I4210167126 |
| authorships[0].institutions[1].country_code | US |
| authorships[0].institutions[1].display_name | UCSF Helen Diller Family Comprehensive Cancer Center |
| authorships[0].institutions[2].id | https://openalex.org/I180670191 |
| authorships[0].institutions[2].ror | https://ror.org/043mz5j54 |
| authorships[0].institutions[2].type | education |
| authorships[0].institutions[2].lineage | https://openalex.org/I180670191 |
| authorships[0].institutions[2].country_code | US |
| authorships[0].institutions[2].display_name | University of California, San Francisco |
| authorships[0].institutions[3].id | https://openalex.org/I79576946 |
| authorships[0].institutions[3].ror | https://ror.org/00b30xv10 |
| authorships[0].institutions[3].type | education |
| authorships[0].institutions[3].lineage | https://openalex.org/I79576946 |
| authorships[0].institutions[3].country_code | US |
| authorships[0].institutions[3].display_name | University of Pennsylvania |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Joel Babdor |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Bakar ImmunoX program, University of California, San Francisco, CA, USA, Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA, Department of Systems Pharmacology and Translational Therapeutics, Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA |
| authorships[1].author.id | https://openalex.org/A5048012003 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-5203-899X |
| authorships[1].author.display_name | Ravi K. Patel |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I180670191 |
| authorships[1].affiliations[0].raw_affiliation_string | Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA, USA |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[1].affiliations[1].raw_affiliation_string | Bakar ImmunoX program, University of California, San Francisco, CA, USA |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I180670191 |
| authorships[1].affiliations[2].raw_affiliation_string | UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA |
| authorships[1].institutions[0].id | https://openalex.org/I180670191 |
| authorships[1].institutions[0].ror | https://ror.org/043mz5j54 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I180670191 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | University of California, San Francisco |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Ravi K Patel |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Bakar ImmunoX program, University of California, San Francisco, CA, USA, Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA, USA, UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA |
| authorships[2].author.id | https://openalex.org/A5066577396 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-3538-2822 |
| authorships[2].author.display_name | Brittany Davidson |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I180670191 |
| authorships[2].affiliations[0].raw_affiliation_string | UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[2].affiliations[1].raw_affiliation_string | Department of Pathology, University of California, San Francisco, CA, USA |
| authorships[2].affiliations[2].institution_ids | https://openalex.org/I180670191 |
| authorships[2].affiliations[2].raw_affiliation_string | Bakar ImmunoX program, University of California, San Francisco, CA, USA |
| authorships[2].institutions[0].id | https://openalex.org/I180670191 |
| authorships[2].institutions[0].ror | https://ror.org/043mz5j54 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I180670191 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | University of California, San Francisco |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Brittany Davidson |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Bakar ImmunoX program, University of California, San Francisco, CA, USA, Department of Pathology, University of California, San Francisco, CA, USA, UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA |
| authorships[3].author.id | https://openalex.org/A5064442372 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-1417-2383 |
| authorships[3].author.display_name | Cecilia Noecker |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I152014189 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Biological Sciences, Minnesota State University, Mankato, Mankato, MN, USA |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[3].affiliations[1].raw_affiliation_string | Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA |
| authorships[3].institutions[0].id | https://openalex.org/I152014189 |
| authorships[3].institutions[0].ror | https://ror.org/04att9732 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I152014189, https://openalex.org/I91221267 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Minnesota State University, Mankato |
| authorships[3].institutions[1].id | https://openalex.org/I180670191 |
| authorships[3].institutions[1].ror | https://ror.org/043mz5j54 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I180670191 |
| authorships[3].institutions[1].country_code | US |
| authorships[3].institutions[1].display_name | University of California, San Francisco |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Cecilia Noecker |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Biological Sciences, Minnesota State University, Mankato, Mankato, MN, USA, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA |
| authorships[4].author.id | https://openalex.org/A5112891731 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-6756-5802 |
| authorships[4].author.display_name | Maha K. Rahim |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I180670191, https://openalex.org/I4210167126 |
| authorships[4].affiliations[0].raw_affiliation_string | Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[4].affiliations[1].raw_affiliation_string | Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA |
| authorships[4].affiliations[2].institution_ids | https://openalex.org/I180670191 |
| authorships[4].affiliations[2].raw_affiliation_string | Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA |
| authorships[4].institutions[0].id | https://openalex.org/I4210167126 |
| authorships[4].institutions[0].ror | https://ror.org/05yndxy10 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I180670191, https://openalex.org/I4210110664, https://openalex.org/I4210167126 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | UCSF Helen Diller Family Comprehensive Cancer Center |
| authorships[4].institutions[1].id | https://openalex.org/I180670191 |
| authorships[4].institutions[1].ror | https://ror.org/043mz5j54 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I180670191 |
| authorships[4].institutions[1].country_code | US |
| authorships[4].institutions[1].display_name | University of California, San Francisco |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Maha Rahim |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA |
| authorships[5].author.id | https://openalex.org/A5068812632 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-8649-1706 |
| authorships[5].author.display_name | Jordan E. Bisanz |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I130769515 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Biochemistry and Molecular Biology, Penn State, University Park, PA, USA |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[5].affiliations[1].raw_affiliation_string | Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA |
| authorships[5].institutions[0].id | https://openalex.org/I130769515 |
| authorships[5].institutions[0].ror | https://ror.org/04p491231 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I130769515 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Pennsylvania State University |
| authorships[5].institutions[1].id | https://openalex.org/I180670191 |
| authorships[5].institutions[1].ror | https://ror.org/043mz5j54 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I180670191 |
| authorships[5].institutions[1].country_code | US |
| authorships[5].institutions[1].display_name | University of California, San Francisco |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Jordan E Bisanz |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Biochemistry and Molecular Biology, Penn State, University Park, PA, USA, Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA |
| authorships[6].author.id | https://openalex.org/A5034997252 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-9833-7669 |
| authorships[6].author.display_name | Iliana Tenvooren |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I180670191 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[6].affiliations[1].raw_affiliation_string | Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA |
| authorships[6].affiliations[2].institution_ids | https://openalex.org/I180670191, https://openalex.org/I4210167126 |
| authorships[6].affiliations[2].raw_affiliation_string | Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA |
| authorships[6].institutions[0].id | https://openalex.org/I4210167126 |
| authorships[6].institutions[0].ror | https://ror.org/05yndxy10 |
| authorships[6].institutions[0].type | facility |
| authorships[6].institutions[0].lineage | https://openalex.org/I180670191, https://openalex.org/I4210110664, https://openalex.org/I4210167126 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | UCSF Helen Diller Family Comprehensive Cancer Center |
| authorships[6].institutions[1].id | https://openalex.org/I180670191 |
| authorships[6].institutions[1].ror | https://ror.org/043mz5j54 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I180670191 |
| authorships[6].institutions[1].country_code | US |
| authorships[6].institutions[1].display_name | University of California, San Francisco |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Iliana Tenvooren |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA |
| authorships[7].author.id | https://openalex.org/A5080671437 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-5343-8696 |
| authorships[7].author.display_name | Diana M. Marquez |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I180670191 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I180670191, https://openalex.org/I4210167126 |
| authorships[7].affiliations[1].raw_affiliation_string | Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA |
| authorships[7].affiliations[2].institution_ids | https://openalex.org/I180670191 |
| authorships[7].affiliations[2].raw_affiliation_string | Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA |
| authorships[7].institutions[0].id | https://openalex.org/I4210167126 |
| authorships[7].institutions[0].ror | https://ror.org/05yndxy10 |
| authorships[7].institutions[0].type | facility |
| authorships[7].institutions[0].lineage | https://openalex.org/I180670191, https://openalex.org/I4210110664, https://openalex.org/I4210167126 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | UCSF Helen Diller Family Comprehensive Cancer Center |
| authorships[7].institutions[1].id | https://openalex.org/I180670191 |
| authorships[7].institutions[1].ror | https://ror.org/043mz5j54 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I180670191 |
| authorships[7].institutions[1].country_code | US |
| authorships[7].institutions[1].display_name | University of California, San Francisco |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Diana Marquez |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA |
| authorships[8].author.id | https://openalex.org/A5047556842 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-3881-3886 |
| authorships[8].author.display_name | Lorena Espinar |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210160145 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Microbiome Therapies Initiative, Stanford, CA, USA |
| authorships[8].institutions[0].id | https://openalex.org/I4210160145 |
| authorships[8].institutions[0].ror | https://ror.org/04ps1h446 |
| authorships[8].institutions[0].type | company |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210160145 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Vital Therapies (United States) |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Maria Calvo |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Microbiome Therapies Initiative, Stanford, CA, USA |
| authorships[9].author.id | https://openalex.org/A5037862957 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-7341-4675 |
| authorships[9].author.display_name | Vrinda Johri |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I180670191 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Pathology, University of California, San Francisco, CA, USA |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[9].affiliations[1].raw_affiliation_string | Bakar ImmunoX program, University of California, San Francisco, CA, USA |
| authorships[9].affiliations[2].institution_ids | https://openalex.org/I180670191 |
| authorships[9].affiliations[2].raw_affiliation_string | UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA |
| authorships[9].institutions[0].id | https://openalex.org/I180670191 |
| authorships[9].institutions[0].ror | https://ror.org/043mz5j54 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I180670191 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | University of California, San Francisco |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Vrinda Johri |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Bakar ImmunoX program, University of California, San Francisco, CA, USA, Department of Pathology, University of California, San Francisco, CA, USA, UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA |
| authorships[10].author.id | https://openalex.org/A5086608811 |
| authorships[10].author.orcid | https://orcid.org/0000-0003-4056-8955 |
| authorships[10].author.display_name | Elizabeth W. McCarthy |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I180670191, https://openalex.org/I4210167126 |
| authorships[10].affiliations[0].raw_affiliation_string | Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA |
| authorships[10].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[10].affiliations[1].raw_affiliation_string | Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA |
| authorships[10].affiliations[2].institution_ids | https://openalex.org/I180670191 |
| authorships[10].affiliations[2].raw_affiliation_string | Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA |
| authorships[10].institutions[0].id | https://openalex.org/I4210167126 |
| authorships[10].institutions[0].ror | https://ror.org/05yndxy10 |
| authorships[10].institutions[0].type | facility |
| authorships[10].institutions[0].lineage | https://openalex.org/I180670191, https://openalex.org/I4210110664, https://openalex.org/I4210167126 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | UCSF Helen Diller Family Comprehensive Cancer Center |
| authorships[10].institutions[1].id | https://openalex.org/I180670191 |
| authorships[10].institutions[1].ror | https://ror.org/043mz5j54 |
| authorships[10].institutions[1].type | education |
| authorships[10].institutions[1].lineage | https://openalex.org/I180670191 |
| authorships[10].institutions[1].country_code | US |
| authorships[10].institutions[1].display_name | University of California, San Francisco |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Elizabeth McCarthy |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA |
| authorships[11].author.id | https://openalex.org/A5093984705 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | Avneet Shaheed |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I180670191 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I180670191, https://openalex.org/I4210167126 |
| authorships[11].affiliations[1].raw_affiliation_string | Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA |
| authorships[11].affiliations[2].institution_ids | https://openalex.org/I180670191 |
| authorships[11].affiliations[2].raw_affiliation_string | Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA |
| authorships[11].institutions[0].id | https://openalex.org/I4210167126 |
| authorships[11].institutions[0].ror | https://ror.org/05yndxy10 |
| authorships[11].institutions[0].type | facility |
| authorships[11].institutions[0].lineage | https://openalex.org/I180670191, https://openalex.org/I4210110664, https://openalex.org/I4210167126 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | UCSF Helen Diller Family Comprehensive Cancer Center |
| authorships[11].institutions[1].id | https://openalex.org/I180670191 |
| authorships[11].institutions[1].ror | https://ror.org/043mz5j54 |
| authorships[11].institutions[1].type | education |
| authorships[11].institutions[1].lineage | https://openalex.org/I180670191 |
| authorships[11].institutions[1].country_code | US |
| authorships[11].institutions[1].display_name | University of California, San Francisco |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Avneet Shaheed |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA |
| authorships[12].author.id | https://openalex.org/A5093935233 |
| authorships[12].author.orcid | https://orcid.org/0009-0004-5182-3573 |
| authorships[12].author.display_name | Christina Ekstrand |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I180670191 |
| authorships[12].affiliations[0].raw_affiliation_string | UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[12].affiliations[1].raw_affiliation_string | Bakar ImmunoX program, University of California, San Francisco, CA, USA |
| authorships[12].affiliations[2].institution_ids | https://openalex.org/I180670191 |
| authorships[12].affiliations[2].raw_affiliation_string | Department of Pathology, University of California, San Francisco, CA, USA |
| authorships[12].institutions[0].id | https://openalex.org/I180670191 |
| authorships[12].institutions[0].ror | https://ror.org/043mz5j54 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I180670191 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | University of California, San Francisco |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Christina Ekstrand |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Bakar ImmunoX program, University of California, San Francisco, CA, USA, Department of Pathology, University of California, San Francisco, CA, USA, UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA |
| authorships[13].author.id | https://openalex.org/A5077545518 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-6694-6964 |
| authorships[13].author.display_name | Allison M. Weakley |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I4210160145 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Microbiome Therapies Initiative, Stanford, CA, USA |
| authorships[13].affiliations[1].institution_ids | https://openalex.org/I4210121800 |
| authorships[13].affiliations[1].raw_affiliation_string | Chan Zuckerberg Biohub – San Francisco, San Francisco, CA 94158, USA |
| authorships[13].institutions[0].id | https://openalex.org/I4210121800 |
| authorships[13].institutions[0].ror | https://ror.org/02qenvm24 |
| authorships[13].institutions[0].type | company |
| authorships[13].institutions[0].lineage | https://openalex.org/I4210121800 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | Chan Zuckerberg Initiative (United States) |
| authorships[13].institutions[1].id | https://openalex.org/I4210160145 |
| authorships[13].institutions[1].ror | https://ror.org/04ps1h446 |
| authorships[13].institutions[1].type | company |
| authorships[13].institutions[1].lineage | https://openalex.org/I4210160145 |
| authorships[13].institutions[1].country_code | US |
| authorships[13].institutions[1].display_name | Vital Therapies (United States) |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Allison M Weakley |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Chan Zuckerberg Biohub – San Francisco, San Francisco, CA 94158, USA, Department of Microbiome Therapies Initiative, Stanford, CA, USA |
| authorships[14].author.id | https://openalex.org/A5042068232 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-3416-3046 |
| authorships[14].author.display_name | Feiqiao Brian Yu |
| authorships[14].countries | US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I4210121800 |
| authorships[14].affiliations[0].raw_affiliation_string | Chan Zuckerberg Biohub – San Francisco, San Francisco, CA 94158, USA |
| authorships[14].institutions[0].id | https://openalex.org/I4210121800 |
| authorships[14].institutions[0].ror | https://ror.org/02qenvm24 |
| authorships[14].institutions[0].type | company |
| authorships[14].institutions[0].lineage | https://openalex.org/I4210121800 |
| authorships[14].institutions[0].country_code | US |
| authorships[14].institutions[0].display_name | Chan Zuckerberg Initiative (United States) |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Feiqiao B Yu |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Chan Zuckerberg Biohub – San Francisco, San Francisco, CA 94158, USA |
| authorships[15].author.id | https://openalex.org/A5087349635 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-6261-8928 |
| authorships[15].author.display_name | Oliver Fiehn |
| authorships[15].countries | US |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I84218800 |
| authorships[15].affiliations[0].raw_affiliation_string | West Coast Metabolomics Center, University of California Davis Genome Center, Davis, CA, USA |
| authorships[15].institutions[0].id | https://openalex.org/I84218800 |
| authorships[15].institutions[0].ror | https://ror.org/05rrcem69 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I84218800 |
| authorships[15].institutions[0].country_code | US |
| authorships[15].institutions[0].display_name | University of California, Davis |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Oliver Fiehn |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | West Coast Metabolomics Center, University of California Davis Genome Center, Davis, CA, USA |
| authorships[16].author.id | https://openalex.org/A5079232459 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-0888-2875 |
| authorships[16].author.display_name | Peter J. Turnbaugh |
| authorships[16].countries | US |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I180670191 |
| authorships[16].affiliations[0].raw_affiliation_string | Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA |
| authorships[16].institutions[0].id | https://openalex.org/I180670191 |
| authorships[16].institutions[0].ror | https://ror.org/043mz5j54 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I180670191 |
| authorships[16].institutions[0].country_code | US |
| authorships[16].institutions[0].display_name | University of California, San Francisco |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Peter J Turnbaugh |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA |
| authorships[17].author.id | https://openalex.org/A5075500453 |
| authorships[17].author.orcid | https://orcid.org/0000-0002-9110-6542 |
| authorships[17].author.display_name | Alexis J. Combes |
| authorships[17].countries | US |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I180670191 |
| authorships[17].affiliations[0].raw_affiliation_string | UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA |
| authorships[17].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[17].affiliations[1].raw_affiliation_string | Bakar ImmunoX program, University of California, San Francisco, CA, USA |
| authorships[17].affiliations[2].institution_ids | https://openalex.org/I180670191 |
| authorships[17].affiliations[2].raw_affiliation_string | Department of Pathology, University of California, San Francisco, CA, USA |
| authorships[17].affiliations[3].institution_ids | https://openalex.org/I180670191 |
| authorships[17].affiliations[3].raw_affiliation_string | Division of Gastroenterology, Department of Medicine, University of California, San Francisco, CA, USA |
| authorships[17].institutions[0].id | https://openalex.org/I180670191 |
| authorships[17].institutions[0].ror | https://ror.org/043mz5j54 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I180670191 |
| authorships[17].institutions[0].country_code | US |
| authorships[17].institutions[0].display_name | University of California, San Francisco |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Alexis J Combes |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Bakar ImmunoX program, University of California, San Francisco, CA, USA, Department of Pathology, University of California, San Francisco, CA, USA, Division of Gastroenterology, Department of Medicine, University of California, San Francisco, CA, USA, UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA |
| authorships[18].author.id | https://openalex.org/A5087928119 |
| authorships[18].author.orcid | https://orcid.org/0000-0001-9703-2591 |
| authorships[18].author.display_name | Gabriela K. Fragiadakis |
| authorships[18].countries | US |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I180670191 |
| authorships[18].affiliations[0].raw_affiliation_string | Bakar ImmunoX program, University of California, San Francisco, CA, USA |
| authorships[18].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[18].affiliations[1].raw_affiliation_string | Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA, USA |
| authorships[18].affiliations[2].institution_ids | https://openalex.org/I180670191 |
| authorships[18].affiliations[2].raw_affiliation_string | UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA |
| authorships[18].institutions[0].id | https://openalex.org/I180670191 |
| authorships[18].institutions[0].ror | https://ror.org/043mz5j54 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I180670191 |
| authorships[18].institutions[0].country_code | US |
| authorships[18].institutions[0].display_name | University of California, San Francisco |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Gabriela K Fragiadakis |
| authorships[18].is_corresponding | True |
| authorships[18].raw_affiliation_strings | Bakar ImmunoX program, University of California, San Francisco, CA, USA, Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA, USA, UCSF CoLabs, University of California San Francisco, San Francisco, CA, USA |
| authorships[19].author.id | https://openalex.org/A5009958453 |
| authorships[19].author.orcid | https://orcid.org/0000-0002-5291-3819 |
| authorships[19].author.display_name | Matthew H. Spitzer |
| authorships[19].countries | US |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I4210109986 |
| authorships[19].affiliations[0].raw_affiliation_string | Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA |
| authorships[19].affiliations[1].institution_ids | https://openalex.org/I180670191 |
| authorships[19].affiliations[1].raw_affiliation_string | Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA |
| authorships[19].affiliations[2].institution_ids | https://openalex.org/I180670191, https://openalex.org/I4210167126 |
| authorships[19].affiliations[2].raw_affiliation_string | Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA |
| authorships[19].affiliations[3].institution_ids | https://openalex.org/I180670191 |
| authorships[19].affiliations[3].raw_affiliation_string | Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA |
| authorships[19].institutions[0].id | https://openalex.org/I4210109986 |
| authorships[19].institutions[0].ror | https://ror.org/0184qbg02 |
| authorships[19].institutions[0].type | facility |
| authorships[19].institutions[0].lineage | https://openalex.org/I4210109986 |
| authorships[19].institutions[0].country_code | US |
| authorships[19].institutions[0].display_name | Parker Institute for Cancer Immunotherapy |
| authorships[19].institutions[1].id | https://openalex.org/I4210167126 |
| authorships[19].institutions[1].ror | https://ror.org/05yndxy10 |
| authorships[19].institutions[1].type | facility |
| authorships[19].institutions[1].lineage | https://openalex.org/I180670191, https://openalex.org/I4210110664, https://openalex.org/I4210167126 |
| authorships[19].institutions[1].country_code | US |
| authorships[19].institutions[1].display_name | UCSF Helen Diller Family Comprehensive Cancer Center |
| authorships[19].institutions[2].id | https://openalex.org/I180670191 |
| authorships[19].institutions[2].ror | https://ror.org/043mz5j54 |
| authorships[19].institutions[2].type | education |
| authorships[19].institutions[2].lineage | https://openalex.org/I180670191 |
| authorships[19].institutions[2].country_code | US |
| authorships[19].institutions[2].display_name | University of California, San Francisco |
| authorships[19].author_position | last |
| authorships[19].raw_author_name | Matthew H. Spitzer |
| authorships[19].is_corresponding | True |
| authorships[19].raw_affiliation_strings | Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, CA, USA, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA, Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11642739 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10887 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9894000291824341 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Bioinformatics and Genomic Networks |
| related_works | https://openalex.org/W2604155846, https://openalex.org/W4390658901, https://openalex.org/W3121185202, https://openalex.org/W4393043634, https://openalex.org/W4206185765, https://openalex.org/W2900546243, https://openalex.org/W3035180550, https://openalex.org/W4388834263, https://openalex.org/W1983943311, https://openalex.org/W3020516445 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:11642739 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | bioRxiv |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11642739 |
| primary_location.id | doi:10.1101/2024.11.27.625750 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2024.11.27.625750 |
| publication_date | 2024-12-03 |
| publication_year | 2024 |
| referenced_works_count | 0 |
| abstract_inverted_index.A | 48 |
| abstract_inverted_index.NK | 100 |
| abstract_inverted_index.at | 125 |
| abstract_inverted_index.in | 68, 90 |
| abstract_inverted_index.of | 29, 40, 104, 122 |
| abstract_inverted_index.to | 10, 112, 142 |
| abstract_inverted_index.we | 36 |
| abstract_inverted_index.110 | 41 |
| abstract_inverted_index.Our | 107 |
| abstract_inverted_index.The | 13 |
| abstract_inverted_index.and | 74, 88, 94, 99, 120, 140 |
| abstract_inverted_index.are | 3 |
| abstract_inverted_index.for | 132, 137 |
| abstract_inverted_index.gut | 14 |
| abstract_inverted_index.its | 22 |
| abstract_inverted_index.the | 18, 25, 45, 57, 63, 114, 117, 130 |
| abstract_inverted_index.was | 61 |
| abstract_inverted_index.way | 131 |
| abstract_inverted_index.CD69 | 95 |
| abstract_inverted_index.MAIT | 98 |
| abstract_inverted_index.data | 111 |
| abstract_inverted_index.high | 92, 96 |
| abstract_inverted_index.most | 7, 64 |
| abstract_inverted_index.that | 56 |
| abstract_inverted_index.were | 102 |
| abstract_inverted_index.with | 6, 24, 79 |
| abstract_inverted_index.Human | 0 |
| abstract_inverted_index.cells | 101 |
| abstract_inverted_index.paves | 129 |
| abstract_inverted_index.stool | 75 |
| abstract_inverted_index.study | 108 |
| abstract_inverted_index.these | 105 |
| abstract_inverted_index.tonic | 58 |
| abstract_inverted_index.which | 128 |
| abstract_inverted_index.TGF-β | 89 |
| abstract_inverted_index.highly | 4 |
| abstract_inverted_index.humans | 31 |
| abstract_inverted_index.immune | 1, 19, 27, 66, 118 |
| abstract_inverted_index.shapes | 17 |
| abstract_inverted_index.state, | 127 |
| abstract_inverted_index.states | 28, 119 |
| abstract_inverted_index.steady | 126 |
| abstract_inverted_index.study. | 47 |
| abstract_inverted_index.varied | 77 |
| abstract_inverted_index.amongst | 62 |
| abstract_inverted_index.between | 116 |
| abstract_inverted_index.disease | 138 |
| abstract_inverted_index.examine | 113 |
| abstract_inverted_index.healthy | 30, 42, 69, 123 |
| abstract_inverted_index.remains | 32 |
| abstract_inverted_index.system; | 20 |
| abstract_inverted_index.systems | 2 |
| abstract_inverted_index.through | 44 |
| abstract_inverted_index.Distinct | 83 |
| abstract_inverted_index.SIGLEC-1 | 91 |
| abstract_inverted_index.approach | 51 |
| abstract_inverted_index.baseline | 26 |
| abstract_inverted_index.features | 67 |
| abstract_inverted_index.however, | 21 |
| abstract_inverted_index.programs | 85 |
| abstract_inverted_index.provides | 109 |
| abstract_inverted_index.relevant | 136 |
| abstract_inverted_index.response | 60, 81 |
| abstract_inverted_index.sources. | 12 |
| abstract_inverted_index.therapy. | 143 |
| abstract_inverted_index.variable | 65 |
| abstract_inverted_index.activated | 97 |
| abstract_inverted_index.crucially | 16 |
| abstract_inverted_index.extensive | 110 |
| abstract_inverted_index.involving | 86 |
| abstract_inverted_index.monocytes | 93 |
| abstract_inverted_index.pathways, | 73 |
| abstract_inverted_index.pathways. | 82 |
| abstract_inverted_index.performed | 37 |
| abstract_inverted_index.profiling | 39 |
| abstract_inverted_index.programs. | 106 |
| abstract_inverted_index.responses | 141 |
| abstract_inverted_index.revealing | 55 |
| abstract_inverted_index.variable, | 5 |
| abstract_inverted_index.variation | 8 |
| abstract_inverted_index.Microbiome | 71 |
| abstract_inverted_index.Therefore, | 35 |
| abstract_inverted_index.identified | 52 |
| abstract_inverted_index.interferon | 59, 80 |
| abstract_inverted_index.microbiome | 15 |
| abstract_inverted_index.multi-omic | 38 |
| abstract_inverted_index.variation, | 54 |
| abstract_inverted_index.coordinated | 53 |
| abstract_inverted_index.delineating | 133 |
| abstract_inverted_index.differences | 135 |
| abstract_inverted_index.individuals | 124 |
| abstract_inverted_index.integrative | 50 |
| abstract_inverted_index.metabolites | 76 |
| abstract_inverted_index.microbiomes | 121 |
| abstract_inverted_index.non-genetic | 11 |
| abstract_inverted_index.understood. | 34 |
| abstract_inverted_index.attributable | 9 |
| abstract_inverted_index.composition, | 72 |
| abstract_inverted_index.factor-based | 49 |
| abstract_inverted_index.incompletely | 33 |
| abstract_inverted_index.inflammation | 87 |
| abstract_inverted_index.participants | 43 |
| abstract_inverted_index.relationship | 23, 115 |
| abstract_inverted_index.concomitantly | 78 |
| abstract_inverted_index.participants. | 70 |
| abstract_inverted_index.representative | 103 |
| abstract_inverted_index.susceptibility | 139 |
| abstract_inverted_index.transcriptional | 84 |
| abstract_inverted_index.ImmunoMicrobiome | 46 |
| abstract_inverted_index.inter-individual | 134 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5009958453, https://openalex.org/A5087928119, https://openalex.org/A5031253566 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 20 |
| corresponding_institution_ids | https://openalex.org/I180670191, https://openalex.org/I4210109986, https://openalex.org/I4210125521, https://openalex.org/I4210167126, https://openalex.org/I79576946 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7200000286102295 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.63500807 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |