Coordination between ESCRT function and Rab conversion during endosome maturation Article Swipe
Daniel P. Ott
,
Samit Desai
,
Jachen A. Solinger
,
Andres Kaech
,
Anne Spang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s44318-025-00367-7
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s44318-025-00367-7
The endosomal pathway is essential for regulating cell signaling and cellular homeostasis. Rab5 positive early endosomes receive proteins from the plasma membrane. Dependent on a ubiquitin mark on the protein, they will be either recycled or sorted into intraluminal vesicles (ILVs) by endosomal sorting complex required for transport (ESCRT) proteins. During endosome maturation Rab5 is replaced by Rab7 on endosomes that are able to fuse with lysosomes to form endolysosomes. However, whether ESCRT-driven ILV formation and Rab5-to-Rab7 conversion are coordinated remains unknown. Here we show that loss of early ESCRTs led to enlarged Rab5 positive endosomes and prohibited Rab conversion. Reduction of ubiquitinated cargo alleviated this phenotype. Moreover, ubiquitinated proteins on the endosomal limiting membrane prevented the displacement of the Rab5 guanine nucleotide exchange factor (GEF) RABX-5 by the GEF for Rab7, SAND-1/CCZ-1. Overexpression of Rab7 could partially overcome this block, even in the absence of SAND-1 or CCZ1, suggesting the presence of a second Rab7 GEF. Our data reveal a hierarchy of events in which cargo corralling by ESCRTs is upstream of Rab conversion, suggesting that ESCRT-0 and ubiquitinated cargo could act as timers that determine the onset of Rab conversion.
Related Topics
Concepts
Endosome
Rab
ESCRT
Cell biology
Biology
Guanine nucleotide exchange factor
Ubiquitin
Transport protein
Small GTPase
Vesicular Transport Proteins
Vacuolar protein sorting
GTPase
Biochemistry
Signal transduction
Intracellular
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s44318-025-00367-7
- OA Status
- diamond
- Cited By
- 7
- References
- 78
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407152605
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407152605Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s44318-025-00367-7Digital Object Identifier
- Title
-
Coordination between ESCRT function and Rab conversion during endosome maturationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-05Full publication date if available
- Authors
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Daniel P. Ott, Samit Desai, Jachen A. Solinger, Andres Kaech, Anne SpangList of authors in order
- Landing page
-
https://doi.org/10.1038/s44318-025-00367-7Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1038/s44318-025-00367-7Direct OA link when available
- Concepts
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Endosome, Rab, ESCRT, Cell biology, Biology, Guanine nucleotide exchange factor, Ubiquitin, Transport protein, Small GTPase, Vesicular Transport Proteins, Vacuolar protein sorting, GTPase, Biochemistry, Signal transduction, Intracellular, GeneTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 7Per-year citation counts (last 5 years)
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78Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| sustainable_development_goals[0].id | https://metadata.un.org/sdg/14 |
| sustainable_development_goals[0].score | 0.5699999928474426 |
| sustainable_development_goals[0].display_name | Life below water |
| citation_normalized_percentile.value | 0.98993811 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |