Copper-quercetin complexes: methods of study, relevance to cell death pathways, therapeutic applications Article Swipe
Michael K. Lawson
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2025.118055
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2025.118055
Copper-quercetin complexes, CuQ, have been an active area of research for several decades. In vitro experiments show complexes are better antioxidants than quercetin alone. There seems to be a synergy effect. Cancer cell culture experiments also show prooxidant and DNA damaging properties which may be exploitable in cancer cell therapy. The effect of copper in combination with quercetin on cell death pathways needs to be investigated, especially regarding the cuproptosis pathway. CuQ complexes may require formulations similar to quercetin. The use of nanoparticles has enabled practical formulations of quercetin and/or their complexes to be made which guarantee stability, satisfactory bioavailability, and clinical effectiveness. In vivo studies are also being reported as well of planning of applications including skin infections and bone healing. Zn, Cu and quercetin tested on mice shows strong potential to treat Androgenic Alopecia. Copper-quercetin complexes seem to be easy to make and have good pharmacological potential in antimicrobial function, osteogenesis, angiogenesis and cancer treatment. Complexes such as those involving phenoanthroline, quercetin and copper may be found to be superior and zinc might be better for cancer therapy.
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- Language
- en
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- OA Status
- gold
- Cited By
- 2
- References
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4409840146Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.biopha.2025.118055Digital Object Identifier
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Copper-quercetin complexes: methods of study, relevance to cell death pathways, therapeutic applicationsWork title
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reviewOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-04-26Full publication date if available
- Authors
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Michael K. LawsonList of authors in order
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https://doi.org/10.1016/j.biopha.2025.118055Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.biopha.2025.118055Direct OA link when available
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Quercetin, Copper, Programmed cell death, Relevance (law), Chemistry, Apoptosis, Biochemistry, Organic chemistry, Political science, Antioxidant, LawTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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108Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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