Core GRADE 2: choosing the target of certainty rating and assessing imprecision Article Swipe
Gordon Guyatt
,
Linan Zeng
,
Romina Brignardello‐Petersen
,
Manya Prasad
,
Hans de Beer
,
M. Hassan Murad
,
Alfonso Iorio
,
Arnav Agarwal
,
Liang Yao
,
Thomas Agoritsas
,
Jamie Rylance
,
Reem A. Mustafa
,
Per Olav Vandvik
,
Prashanti Eachempati
,
Chunjuan Zhai
,
Lingli Zhang
,
Víctor M. Montori
,
Monica Hultcrantz
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1136/bmj-2024-081904
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1136/bmj-2024-081904
This second article in a seven part series presents the Core GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to deciding on the target of the certainty rating, and decisions about rating down certainty of evidence due to imprecision. Core GRADE users assess if the true underlying treatment effect is important or not in relation to the minimal important difference (MID) or, alternatively, if a true underlying treatment effect exists. The location of the point estimate of effect in relation to the chosen threshold determines the target. For instance, using the MID thresholds, a point estimate greater than the MID suggests an important effect and less than the MID, an unimportant or little to no effect. Users then rate down for imprecision if the 95% confidence interval crosses the MID for benefit or harm.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/bmj-2024-081904
- https://www.bmj.com/content/bmj/389/bmj-2024-081904.full.pdf
- OA Status
- bronze
- Cited By
- 14
- References
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- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409920683
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409920683Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1136/bmj-2024-081904Digital Object Identifier
- Title
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Core GRADE 2: choosing the target of certainty rating and assessing imprecisionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-04-29Full publication date if available
- Authors
-
Gordon Guyatt, Linan Zeng, Romina Brignardello‐Petersen, Manya Prasad, Hans de Beer, M. Hassan Murad, Alfonso Iorio, Arnav Agarwal, Liang Yao, Thomas Agoritsas, Jamie Rylance, Reem A. Mustafa, Per Olav Vandvik, Prashanti Eachempati, Chunjuan Zhai, Lingli Zhang, Víctor M. Montori, Monica HultcrantzList of authors in order
- Landing page
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https://doi.org/10.1136/bmj-2024-081904Publisher landing page
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https://www.bmj.com/content/bmj/389/bmj-2024-081904.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://www.bmj.com/content/bmj/389/bmj-2024-081904.full.pdfDirect OA link when available
- Concepts
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Certainty, Computer science, Core (optical fiber), Medicine, Information retrieval, Mathematics, Telecommunications, GeometryTop concepts (fields/topics) attached by OpenAlex
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14Total citation count in OpenAlex
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2025: 14Per-year citation counts (last 5 years)
- References (count)
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14Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| primary_location.is_published | True |
| primary_location.raw_source_name | BMJ |
| primary_location.landing_page_url | https://doi.org/10.1136/bmj-2024-081904 |
| publication_date | 2025-04-29 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4409654354, https://openalex.org/W2616456691, https://openalex.org/W3152804121, https://openalex.org/W4289779569, https://openalex.org/W1583848026, https://openalex.org/W4289938702, https://openalex.org/W6881383655, https://openalex.org/W3111011457, https://openalex.org/W4362640557, https://openalex.org/W4385336753, https://openalex.org/W4408245171, https://openalex.org/W3141014958, https://openalex.org/W2983079501, https://openalex.org/W2090132603 |
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