Correction: A real-life experience with eculizumab and efgartigimod in generalized myasthenia gravis patients Article Swipe
Chiara Pane
,
Vincenzo Di Stefano
,
Nunzia Cuomo
,
Alessio Sarnataro
,
Claudia Vinciguerra
,
Liliana Bevilacqua
,
Filippo Brighina
,
Nicasio Rini
,
Giorgia Puorro
,
Angela Marsili
,
Matteo Garibaldi
,
Laura Fionda
,
Francesco Saccà
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s00415-025-13061-9
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s00415-025-13061-9
Introduction Eculizumab, a complement active antibody, and efgartigimod, an Fc fragment that blocks neonatal Fc receptor, are both approved to treat generalized myasthenia gravis (gMG) patients. The objective of this study is to describe the clinical response to both treatments in a real-life setting. Methods We collected baseline and follow-up clinical data using the Myasthenia Gravis-Activities of Daily Living (MG-ADL), and Quantitative Myasthenia Gravis (QMG). We included 63 patients, 32 treated with eculizumab and 31 with efgartigimod. Of the efgartigimod-treated patients, 22 were anti-acetylcholine receptor antibody-positive (AChR-Ab +) and 9 were AChR-Ab- (3 MuSK-Ab + and 6 seronegative). Results Both treatments showed similar efficacy relative to the MG-ADL scale reduction (p = 0.237). Efgartigimod had a similar effect on both AChR-Ab + and AChR-Ab- (p = 0.280). Eculizumab was superior to efgartigimod relative to the QMG score reduction for the entire dataset (p = 0.003) and was more likely to achieve a clinical response at the QMG compared to efgartigimod (OR 1.373; p = 0.016). Steroid-sparing effect was higher for eculizumab than efgartigimod ( – 16.7 vs – 5.2 mg of the baseline daily dose at follow-up; p = 0.001). Mean speed of prednisone reduction was – 13.1 mg of the daily dose for each month of follow-up for eculizumab-treated patients and – 3.2 for efgartigimod (p = 0.001). We found three serious events, all not related to treatment in the investigator’s opinion. One eculizumab-treated patient experienced a severe pneumonia and died despite treatment. Conclusions Our study provides evidence that eculizumab and efgartigimod can be used in clinical practice to reduce disability in gMG patients. Eculizumab-treated patients had a higher QMG response and steroid sparing effect. Efgartigimod may offer a more flexible schedule due to its cyclical use, no need for vaccination, and efficacy in AChR-Ab- patients.
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Metadata
- Type
- erratum
- Language
- en
- Landing Page
- https://doi.org/10.1007/s00415-025-13061-9
- https://link.springer.com/content/pdf/10.1007/s00415-025-13061-9.pdf
- OA Status
- hybrid
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409924671
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409924671Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1007/s00415-025-13061-9Digital Object Identifier
- Title
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Correction: A real-life experience with eculizumab and efgartigimod in generalized myasthenia gravis patientsWork title
- Type
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erratumOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-29Full publication date if available
- Authors
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Chiara Pane, Vincenzo Di Stefano, Nunzia Cuomo, Alessio Sarnataro, Claudia Vinciguerra, Liliana Bevilacqua, Filippo Brighina, Nicasio Rini, Giorgia Puorro, Angela Marsili, Matteo Garibaldi, Laura Fionda, Francesco SaccàList of authors in order
- Landing page
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https://doi.org/10.1007/s00415-025-13061-9Publisher landing page
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https://link.springer.com/content/pdf/10.1007/s00415-025-13061-9.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://link.springer.com/content/pdf/10.1007/s00415-025-13061-9.pdfDirect OA link when available
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Eculizumab, Myasthenia gravis, Neurology, Neuroradiology, Medicine, Pediatrics, Intensive care medicine, Internal medicine, Immunology, Psychiatry, Complement system, AntibodyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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