Correction: Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African Ancestry Article Swipe
YOU?
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· 2021
· Open Access
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· DOI: https://doi.org/10.17615/nnk8-vz92
Adult height is a classic polygenic trait of high heritability (h 2 ∼0.8). More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. These variants convey modest effects and explain ∼10% of the variance in height. Discovery efforts in other populations, while limited, have revealed loci for height not previously implicated in individuals of European ancestry. Here, we performed a meta-analysis of genome-wide association (GWA) results for adult height in 20,427 individuals of African ancestry with replication in up to 16,436 African Americans. We found two novel height loci (Xp22-rs12393627, P = 3.4×10−12 and 2p14-rs4315565, P = 1.2×10−8). As a group, height associations discovered in European-ancestry samples replicate in individuals of African ancestry (P = 1.7×10−4 for overall replication). Fine-mapping of the European height loci in African-ancestry individuals showed an enrichment of SNPs that are associated with expression of nearby genes when compared to the index European height SNPs (P<0.01). Our results highlight the utility of genetic studies in non-European populations to understand the etiology of complex human diseases and traits.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.17615/nnk8-vz92
- OA Status
- green
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4299300478
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4299300478Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.17615/nnk8-vz92Digital Object Identifier
- Title
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Correction: Identification, Replication, and Fine-Mapping of Loci Associated with Adult Height in Individuals of African AncestryWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
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2021-06-24Full publication date if available
- Authors
-
Amidou N’Diaye, Gary K. Chen, Cameron D. Palmer, Bing Ge, Bamidele O. Tayo, Rasika A. Mathias, Jingzhong Ding, Michael A. Nalls, Adebowale Adeyemo, Véronique Adoue, Christine B. Ambrosone, Larry D. Atwood, Elisa V. Bandera, Lewis C. Becker, Sonja I. Berndt, Leslie Bernstein, William J. Blot, Eric Boerwinkle, Angela Britton, Graham Casey, Stephen J. Chanock, Ellen W. Demerath, Sandra L. Deming, W. Ryan Diver, Caroline S. Fox, Tamara B. Harris, Dena G. Hernandez, Jennifer J. Hu, Sue A. Ingles, Esther M. John, Craig Johnson, Brendan J. KeatingList of authors in order
- Landing page
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https://doi.org/10.17615/nnk8-vz92Publisher landing page
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://doi.org/10.17615/nnk8-vz92Direct OA link when available
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Replication (statistics), Identification (biology), Genetics, Evolutionary biology, Biology, Computational biology, Geography, Genealogy, History, Virology, EcologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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