CORRECTION OF PHOTOBLEACHING FOR THE ASSESSMENT OF PHARMACOKINETIC PARAMETERS USING DYNAMIC FLUORESCENCE MICROSCOPY Article Swipe
Marc Derieppe
,
Clemens Bos
,
Martijn de Greef
,
Chrit Moonen
,
Baudouin Denis de Senneville
·
YOU?
·
· 2024
· Open Access
·
YOU?
·
· 2024
· Open Access
·
Local drug delivery in oncology aims at depositing high doses of anticancer agents while limiting their toxic side effects. Biological barriers, such as cell plasma membranes, hinder their delivery and requires strategies to address this challenge. Previously [1], we demonstrated the feasibility to monitor in real-time, with dynamic fluorescence microscopy, the in-tracellular delivery of a hydrophilic model drug mediated by ultrasound (US), and to quantify the pharmacokinetic parameters derived from a two-compartment model. We evaluate here the impact of the photobleaching (PB) effect experimentally , and compute the PB-corrected uptake kinetics.
Related Topics
Concepts
Photobleaching
Fluorescence recovery after photobleaching
Limiting
Pharmacokinetics
Fluorescence microscope
Drug delivery
Kinetics
Microscopy
Fluorescence
Compartment (ship)
Chemistry
Biophysics
Nanotechnology
Biomedical engineering
Materials science
Computer science
Membrane
Pharmacology
Medicine
Optics
Pathology
Physics
Biochemistry
Engineering
Biology
Geology
Mechanical engineering
Oceanography
Quantum mechanics
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://hal.science/hal-01259351
- OA Status
- green
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2615440161
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2615440161Canonical identifier for this work in OpenAlex
- Title
-
CORRECTION OF PHOTOBLEACHING FOR THE ASSESSMENT OF PHARMACOKINETIC PARAMETERS USING DYNAMIC FLUORESCENCE MICROSCOPYWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-04Full publication date if available
- Authors
-
Marc Derieppe, Clemens Bos, Martijn de Greef, Chrit Moonen, Baudouin Denis de SennevilleList of authors in order
- Landing page
-
https://hal.science/hal-01259351Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://hal.science/hal-01259351Direct OA link when available
- Concepts
-
Photobleaching, Fluorescence recovery after photobleaching, Limiting, Pharmacokinetics, Fluorescence microscope, Drug delivery, Kinetics, Microscopy, Fluorescence, Compartment (ship), Chemistry, Biophysics, Nanotechnology, Biomedical engineering, Materials science, Computer science, Membrane, Pharmacology, Medicine, Optics, Pathology, Physics, Biochemistry, Engineering, Biology, Geology, Mechanical engineering, Oceanography, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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