Correlation of Presynaptic and Postsynaptic Proteins with Pathology in Alzheimer’s Disease Article Swipe
Geidy E. Serrano
,
Jessica E. Walker
,
Courtney M. Nelson
,
Michael J. Glass
,
Richard Arce
,
Anthony J. Intorcia
,
Madison P. Cline
,
Natalie Lana Nabaty
,
Amanda M. Acuña
,
Ashton Huppert Steed
,
Lucia I. Sue
,
Christine M. Belden
,
Parichita Choudhury
,
Eric M. Reiman
,
Alireza Atri
,
Thomas G. Beach
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25063130
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25063130
Synaptic transmission is essential for nervous system function and the loss of synapses is a known major contributor to dementia. Alzheimer’s disease dementia (ADD) is characterized by synaptic loss in the mesial temporal lobe and cerebral neocortex, both of which are brain areas associated with memory and cognition. The association of synaptic loss and ADD was established in the late 1980s, and it has been estimated that 30–50% of neocortical synaptic protein is lost in ADD, but there has not yet been a quantitative profiling of different synaptic proteins in different brain regions in ADD from the same individuals. Very recently, positron emission tomography (PET) imaging of synapses is being developed, accelerating the focus on the role of synaptic loss in ADD and other conditions. In this study, we quantified the densities of two synaptic proteins, the presynaptic protein Synaptosome Associated Protein 25 (SNAP25) and the postsynaptic protein postsynaptic density protein 95 (PSD95) in the human brain, using enzyme-linked immunosorbent assays (ELISA). Protein was extracted from the cingulate gyrus, hippocampus, frontal, primary visual, and entorhinal cortex from cognitively unimpaired controls, subjects with mild cognitive impairment (MCI), and subjects with dementia that have different levels of Alzheimer’s pathology. SNAP25 is significantly reduced in ADD when compared to controls in the frontal cortex, visual cortex, and cingulate, while the hippocampus showed a smaller, non-significant reduction, and entorhinal cortex concentrations were not different. In contrast, all brain areas showed lower PSD95 concentrations in ADD when compared to controls without dementia, although in the hippocampus, this failed to reach significance. Interestingly, cognitively unimpaired cases with high levels of AD pathology had higher levels of both synaptic proteins in all brain regions. SNAP25 and PSD95 concentrations significantly correlated with densities of neurofibrillary tangles, amyloid plaques, and Mini Mental State Examination (MMSE) scores. Our results suggest that synaptic transmission is affected by ADD in multiple brain regions. The differences were less marked in the entorhinal cortex and the hippocampus, most likely due to a ceiling effect imposed by the very early development of neurofibrillary tangles in older people in these brain regions.
Related Topics
Concepts
Neuroscience
Entorhinal cortex
Neocortex
Hippocampus
Postsynaptic potential
Dementia with Lewy bodies
Postsynaptic density
Dementia
Biology
Psychology
Medicine
Pathology
Inhibitory postsynaptic potential
Internal medicine
Excitatory postsynaptic potential
Disease
Receptor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms25063130
- https://www.mdpi.com/1422-0067/25/6/3130/pdf?version=1709891329
- OA Status
- gold
- Cited By
- 6
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392588697
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4392588697Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms25063130Digital Object Identifier
- Title
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Correlation of Presynaptic and Postsynaptic Proteins with Pathology in Alzheimer’s DiseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-08Full publication date if available
- Authors
-
Geidy E. Serrano, Jessica E. Walker, Courtney M. Nelson, Michael J. Glass, Richard Arce, Anthony J. Intorcia, Madison P. Cline, Natalie Lana Nabaty, Amanda M. Acuña, Ashton Huppert Steed, Lucia I. Sue, Christine M. Belden, Parichita Choudhury, Eric M. Reiman, Alireza Atri, Thomas G. BeachList of authors in order
- Landing page
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https://doi.org/10.3390/ijms25063130Publisher landing page
- PDF URL
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https://www.mdpi.com/1422-0067/25/6/3130/pdf?version=1709891329Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/1422-0067/25/6/3130/pdf?version=1709891329Direct OA link when available
- Concepts
-
Neuroscience, Entorhinal cortex, Neocortex, Hippocampus, Postsynaptic potential, Dementia with Lewy bodies, Postsynaptic density, Dementia, Biology, Psychology, Medicine, Pathology, Inhibitory postsynaptic potential, Internal medicine, Excitatory postsynaptic potential, Disease, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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48Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.higher | 267 |
| abstract_inverted_index.levels | 193, 262, 268 |
| abstract_inverted_index.likely | 324 |
| abstract_inverted_index.marked | 315 |
| abstract_inverted_index.memory | 45 |
| abstract_inverted_index.mesial | 31 |
| abstract_inverted_index.people | 341 |
| abstract_inverted_index.showed | 218, 235 |
| abstract_inverted_index.study, | 127 |
| abstract_inverted_index.system | 6 |
| abstract_inverted_index.visual | 211 |
| abstract_inverted_index.(PSD95) | 152 |
| abstract_inverted_index.Protein | 141, 162 |
| abstract_inverted_index.amyloid | 288 |
| abstract_inverted_index.ceiling | 328 |
| abstract_inverted_index.cortex, | 210, 212 |
| abstract_inverted_index.density | 149 |
| abstract_inverted_index.disease | 21 |
| abstract_inverted_index.frontal | 209 |
| abstract_inverted_index.imaging | 105 |
| abstract_inverted_index.imposed | 330 |
| abstract_inverted_index.nervous | 5 |
| abstract_inverted_index.primary | 171 |
| abstract_inverted_index.protein | 71, 138, 147, 150 |
| abstract_inverted_index.reduced | 200 |
| abstract_inverted_index.regions | 92 |
| abstract_inverted_index.results | 298 |
| abstract_inverted_index.scores. | 296 |
| abstract_inverted_index.suggest | 299 |
| abstract_inverted_index.tangles | 338 |
| abstract_inverted_index.visual, | 172 |
| abstract_inverted_index.without | 245 |
| abstract_inverted_index.(ELISA). | 161 |
| abstract_inverted_index.(SNAP25) | 143 |
| abstract_inverted_index.30–50% | 67 |
| abstract_inverted_index.Synaptic | 0 |
| abstract_inverted_index.affected | 304 |
| abstract_inverted_index.although | 247 |
| abstract_inverted_index.cerebral | 35 |
| abstract_inverted_index.compared | 204, 242 |
| abstract_inverted_index.controls | 206, 244 |
| abstract_inverted_index.dementia | 22, 189 |
| abstract_inverted_index.emission | 102 |
| abstract_inverted_index.frontal, | 170 |
| abstract_inverted_index.function | 7 |
| abstract_inverted_index.multiple | 308 |
| abstract_inverted_index.plaques, | 289 |
| abstract_inverted_index.positron | 101 |
| abstract_inverted_index.proteins | 88, 272 |
| abstract_inverted_index.regions. | 276, 310, 345 |
| abstract_inverted_index.smaller, | 220 |
| abstract_inverted_index.subjects | 180, 187 |
| abstract_inverted_index.synapses | 12, 107 |
| abstract_inverted_index.synaptic | 27, 51, 70, 87, 118, 134, 271, 301 |
| abstract_inverted_index.tangles, | 287 |
| abstract_inverted_index.temporal | 32 |
| abstract_inverted_index.cingulate | 167 |
| abstract_inverted_index.cognitive | 183 |
| abstract_inverted_index.contrast, | 231 |
| abstract_inverted_index.controls, | 179 |
| abstract_inverted_index.dementia, | 246 |
| abstract_inverted_index.dementia. | 19 |
| abstract_inverted_index.densities | 131, 284 |
| abstract_inverted_index.different | 86, 90, 192 |
| abstract_inverted_index.essential | 3 |
| abstract_inverted_index.estimated | 65 |
| abstract_inverted_index.extracted | 164 |
| abstract_inverted_index.pathology | 265 |
| abstract_inverted_index.profiling | 84 |
| abstract_inverted_index.proteins, | 135 |
| abstract_inverted_index.recently, | 100 |
| abstract_inverted_index.Associated | 140 |
| abstract_inverted_index.associated | 43 |
| abstract_inverted_index.cingulate, | 214 |
| abstract_inverted_index.cognition. | 47 |
| abstract_inverted_index.correlated | 282 |
| abstract_inverted_index.developed, | 110 |
| abstract_inverted_index.different. | 229 |
| abstract_inverted_index.entorhinal | 174, 224, 318 |
| abstract_inverted_index.impairment | 184 |
| abstract_inverted_index.neocortex, | 36 |
| abstract_inverted_index.pathology. | 196 |
| abstract_inverted_index.quantified | 129 |
| abstract_inverted_index.reduction, | 222 |
| abstract_inverted_index.tomography | 103 |
| abstract_inverted_index.unimpaired | 178, 258 |
| abstract_inverted_index.Examination | 294 |
| abstract_inverted_index.Synaptosome | 139 |
| abstract_inverted_index.association | 49 |
| abstract_inverted_index.cognitively | 177, 257 |
| abstract_inverted_index.conditions. | 124 |
| abstract_inverted_index.contributor | 17 |
| abstract_inverted_index.development | 335 |
| abstract_inverted_index.differences | 312 |
| abstract_inverted_index.established | 56 |
| abstract_inverted_index.hippocampus | 217 |
| abstract_inverted_index.neocortical | 69 |
| abstract_inverted_index.presynaptic | 137 |
| abstract_inverted_index.accelerating | 111 |
| abstract_inverted_index.hippocampus, | 169, 250, 322 |
| abstract_inverted_index.individuals. | 98 |
| abstract_inverted_index.postsynaptic | 146, 148 |
| abstract_inverted_index.quantitative | 83 |
| abstract_inverted_index.transmission | 1, 302 |
| abstract_inverted_index.Alzheimer’s | 20, 195 |
| abstract_inverted_index.characterized | 25 |
| abstract_inverted_index.enzyme-linked | 158 |
| abstract_inverted_index.immunosorbent | 159 |
| abstract_inverted_index.significance. | 255 |
| abstract_inverted_index.significantly | 199, 281 |
| abstract_inverted_index.Interestingly, | 256 |
| abstract_inverted_index.concentrations | 226, 238, 280 |
| abstract_inverted_index.neurofibrillary | 286, 337 |
| abstract_inverted_index.non-significant | 221 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5050607848 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 16 |
| corresponding_institution_ids | https://openalex.org/I4210145600 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.4300000071525574 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.89563548 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |