Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine development Article Swipe
Guo‐Jen Huang
,
Xin Dong
,
Xiaoxiao Shao
,
Mengping Wu
,
Shan Gao
,
Yixuan Wang
,
Xinying Guan
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2025.1556498
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2025.1556498
Background Migraine, a condition stemming from neurological and vascular irregularities with inflammation involvement, was investigated in a case-control study focusing on the Chinese Han population. Methods The research analyzed specific genetic variations—TNF-α −308 G/A, TNF-α −857 C/T, TNF-α −238G/A, IL1B-3953 C/T, and IL1RN −2018T/C SNPs—within 212 migraine patients and 210 healthy controls. Utilizing SNaPshot technology, scientists genotyped these markers related to TNF-α and IL-1 genes. Results Findings revealed a significant association between the IL1B−3953 C/T SNP and migraine susceptibility, particularly noting its link with a familial history of the disorder. The presence of the C allele at this location was more prevalent in migraine sufferers. Multivariate analysis reinforced this connection, indicating the C allele under a dominant model as an independent risk factor for migraine (OR = 2.315, 95%CI: 1.053–5.090, P = 0.037). Additionally, the study observed a sex-specific difference regarding the TNF-α −857 C/T SNP among migraine patients. Conclusion Overall, this investigation contributes to understanding the genetic underpinnings of migraine in the Han Chinese population, highlighting the IL1B−3953 C/T SNP as a potential biomarker for migraine susceptibility.
Related Topics
Concepts
Single-nucleotide polymorphism
Correlation
Migraine
Tumor necrosis factor alpha
Interleukin
Genetics
Interleukin 1β
Tumor necrosis factor α
Biology
Medicine
Bioinformatics
Immunology
Computational biology
Internal medicine
Gene
Genotype
Cytokine
Mathematics
Geometry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fgene.2025.1556498
- https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1556498/pdf
- OA Status
- gold
- Cited By
- 1
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409826555
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409826555Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fgene.2025.1556498Digital Object Identifier
- Title
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Correlation of tumor necrosis factor-α and interleukin-1 single-nucleotide polymorphisms with the risk of migraine developmentWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-25Full publication date if available
- Authors
-
Guo‐Jen Huang, Xin Dong, Xiaoxiao Shao, Mengping Wu, Shan Gao, Yixuan Wang, Xinying GuanList of authors in order
- Landing page
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https://doi.org/10.3389/fgene.2025.1556498Publisher landing page
- PDF URL
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https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1556498/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1556498/pdfDirect OA link when available
- Concepts
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Single-nucleotide polymorphism, Correlation, Migraine, Tumor necrosis factor alpha, Interleukin, Genetics, Interleukin 1β, Tumor necrosis factor α, Biology, Medicine, Bioinformatics, Immunology, Computational biology, Internal medicine, Gene, Genotype, Cytokine, Mathematics, GeometryTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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37Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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