Correlations between ATF3 polymorphisms and ischemic stroke in Dali, Yunnan Province, as determined by a case-control study Article Swipe

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Single-nucleotide polymorphism Genotype Haplotype SNP Genetic predisposition Internal medicine Case-control study Activating transcription factor Biology Genotype frequency Odds ratio Genetics Immunology Medicine Gene Transcription factor

Yunhui Yang , Pengyu Wang , Min Wang , Guangming Wang ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.21203/rs.3.rs-3675590/v1 · OA: W4389166578

<title>Abstract</title> <bold>Background: </bold>Genetic factors play an important role in ischemic stroke (IS) onset. Activating transcription factor 3 (<italic>ATF3</italic>) is a known IS biomarker; however, the association between <italic>ATF3</italic>polymorphisms and susceptibility to IS remains unclear. Therefore, we aimed to explore the association between <italic>ATF3</italic>single-nucleotide polymorphisms (SNPs) and genetic susceptibility to IS in a population in Dali, Yunnan, China. <bold>Methods: </bold>We included 145 patients with IS and 127 healthy controls in this case-control study. <italic>ATF3</italic>SNP sites (rs1105899, rs1008737, rs1195474, and rs1195472) were genotyped using SNaPshot detection. <bold>Results:</bold> Venous serum glucose (VSG), white blood cell count, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and systolic blood pressure (SBP) were IS risk factors; VSG had the highest impact on IS susceptibility, whereas SBP had the lowest. Genotype distributions of rs1105899, rs1008737, and rs1195472 polymorphisms in the control group conformed to the Hardy–Weinberg equilibrium. Association analysis between <italic>ATF3</italic> polymorphisms and IS risk showed that rs1105899, rs1008737, and rs1195474 <italic>ATF3</italic> polymorphisms were not significantly associated with IS risk. In the codominant and superdominant model of the rs1195472 [C/T] loci, CT carriers exhibited a lower IS risk than CT and TT carriers. Haplotype AGAC was an inhibitory factor for IS. The GTEx database showed that the rs1195472 CT genotype increased <italic>ATF3</italic> expression and was associated with its expression in individual tissues. <bold>Conclusion: </bold>The rs1195472 polymorphism was associated with IS risk in our study population; no significant correlation was noted between rs1105899, rs1008737, and rs1195474 polymorphisms and IS.