Correspondence: insulin resistance and chronic kidney disease in patients without diabetes Article Swipe
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· 2025
· Open Access
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· DOI: https://doi.org/10.1186/s12882-025-04005-6
Future investigations on the association between insulin resistance in people without diabetes and chronic kidney disease (CKD) should consider the following aspects to facilitate causal inference and provide more robust findings. The study design should have an adequate follow-up period to rule out reverse causation and pre-existing diabetes, as well as to confirm the diagnosis of CKD. Known causes of CKD and relevant covariates should be identified where possible. Homeostasis model assessment of insulin resistance (HOMA-IR), being an indirect measure of insulin resistance, has limited sensitivity and specificity compared to direct methods like the hyperinsulinaemic-euglycaemic clamp. Regression modelling with HOMA-IR quartiles instead of continuous form may have masked more nuanced relationships. Sensitivity analyses, such as spline regression, could provide more insights about the association and mechanism. Propensity score methods could help address the inadequate overlap in covariate distributions, if present, by ensuring covariate balance. When investigating the CKD diagnostic performance of HOMA-IR, its cut-off for clinically meaningful insulin resistance should be well justified or comprehensively explored to improve the reliability of the results.
Related Topics
- Type
- letter
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12882-025-04005-6
- OA Status
- gold
- References
- 9
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4407231431
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4407231431Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s12882-025-04005-6Digital Object Identifier
- Title
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Correspondence: insulin resistance and chronic kidney disease in patients without diabetesWork title
- Type
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letterOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-07Full publication date if available
- Authors
-
Hong Tham Pham, Kim‐Huong Truong‐Nguyen, Minh‐Hoang TranList of authors in order
- Landing page
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https://doi.org/10.1186/s12882-025-04005-6Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1186/s12882-025-04005-6Direct OA link when available
- Concepts
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Medicine, Nephrology, Insulin resistance, Diabetes mellitus, Internal medicine, Kidney disease, Type 2 diabetes, Disease, Insulin, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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9Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| publication_date | 2025-02-07 |
| publication_year | 2025 |
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