Cost-benefit analysis: Newborn screening for inborn errors of metabolism in Lebanon Article Swipe
Issam Khneisser
,
S M Adib
,
Shafika Assaad
,
André Mégarbané
,
Pascale E. Karam
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1177/0969141315590675
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1177/0969141315590675
Objectives Few countries in the Middle East-North Africa region have adopted national newborn screening for inborn errors of metabolism by tandem mass spectrometry (MS/MS). We aimed to evaluate the cost-benefit of newborn screening for such disorders in Lebanon, as a model for other developing countries in the region. Methods Average costs of expected care for inborn errors of metabolism cases as a group, between ages 0 and 18, early and late diagnosed, were calculated from 2007 to 2013. The monetary value of early detection using MS/MS was compared with that of clinical “late detection”, including cost of diagnosis and hospitalizations. Results During this period, 126000 newborns were screened. Incidence of detected cases was 1/1482, which can be explained by high consanguinity rates in Lebanon. A reduction by half of direct cost of care, reaching on average 31,631 USD per detected case was shown. This difference more than covers the expense of starting a newborn screening programme. Conclusion Although this model does not take into consideration the indirect benefits of the better quality of life of those screened early, it can be argued that direct and indirect costs saved through early detection of these disorders are important enough to justify universal publicly-funded screening, especially in developing countries with high consanguinity rates, as shown through this data from Lebanon.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/0969141315590675
- https://journals.sagepub.com/doi/pdf/10.1177/0969141315590675
- OA Status
- bronze
- Cited By
- 43
- References
- 17
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2190482122
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2190482122Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1177/0969141315590675Digital Object Identifier
- Title
-
Cost-benefit analysis: Newborn screening for inborn errors of metabolism in LebanonWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-06-10Full publication date if available
- Authors
-
Issam Khneisser, S M Adib, Shafika Assaad, André Mégarbané, Pascale E. KaramList of authors in order
- Landing page
-
https://doi.org/10.1177/0969141315590675Publisher landing page
- PDF URL
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https://journals.sagepub.com/doi/pdf/10.1177/0969141315590675Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
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https://journals.sagepub.com/doi/pdf/10.1177/0969141315590675Direct OA link when available
- Concepts
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Newborn screening, Medicine, Consanguinity, Pediatrics, Incidence (geometry), Environmental health, Developing country, Inborn error of metabolism, Demography, Internal medicine, Optics, Physics, Sociology, Economic growth, EconomicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
43Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 6, 2023: 4, 2022: 11, 2021: 5Per-year citation counts (last 5 years)
- References (count)
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17Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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