Cost-Effectiveness of Screening Algorithms for Familial Hypercholesterolaemia in Primary Care Article Swipe
Matthew Jones
,
Ralph Kwame Akyea
,
Katherine Payne
,
Steve E. Humphries
,
Hasidah Abdul-Hamid
,
Stephen Weng
,
Nadeem Qureshi
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/jpm12030330
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/jpm12030330
Although familial hypercholesterolemia (FH) screening within primary care is considered cost-effective, which screening approach is cost-effective has not been established. This study determines the cost-effectiveness of six case-finding strategies for screening of electronic health records to identify index patients who have genetically confirmed monogenic FH in English primary care. A decision tree was constructed to represent pathways of care for each approach (FH Case Identification Tool (FAMCAT) versions 1 and 2, cholesterol screening, Dutch Lipid Clinic Network (DLCN), Simon Broome criteria, no active screening). Clinical effectiveness was measured as the number of monogenic FH cases identified. Healthcare costs for each algorithm were evaluated from an NHS England perspective over a 12 week time horizon. The primary outcome was the incremental cost per additional monogenic FH case identified (ICER). FAMCAT2 was found to dominate (cheaper and more effective) cholesterol and FAMCAT1 algorithms, and extendedly dominate DLCN. The ICER for FAMCAT2 vs. no active screening was 8111 GBP (95% CI: 4088 to 14,865), and for Simon Broome vs. FAMCAT2 was 74,059 GBP (95% CI: −1,113,172 to 1,697,142). Simon Broome found the largest number of FH cases yet required 102 genetic tests to identify one FH patient. FAMCAT2 identified fewer, but only required 23 genetic tests.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jpm12030330
- https://www.mdpi.com/2075-4426/12/3/330/pdf?version=1645699974
- OA Status
- gold
- Cited By
- 10
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4213455031
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4213455031Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jpm12030330Digital Object Identifier
- Title
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Cost-Effectiveness of Screening Algorithms for Familial Hypercholesterolaemia in Primary CareWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-02-22Full publication date if available
- Authors
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Matthew Jones, Ralph Kwame Akyea, Katherine Payne, Steve E. Humphries, Hasidah Abdul-Hamid, Stephen Weng, Nadeem QureshiList of authors in order
- Landing page
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https://doi.org/10.3390/jpm12030330Publisher landing page
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https://www.mdpi.com/2075-4426/12/3/330/pdf?version=1645699974Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2075-4426/12/3/330/pdf?version=1645699974Direct OA link when available
- Concepts
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Primary care, Medicine, Algorithm, Computer science, Bioinformatics, Family medicine, BiologyTop concepts (fields/topics) attached by OpenAlex
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10Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 6, 2022: 1Per-year citation counts (last 5 years)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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