COX6B2 drives metabolic reprogramming toward oxidative phosphorylation to promote metastasis in pancreatic ductal cancer cells Article Swipe
Ke Nie
,
Jin Li
,
Xujun He
,
Yuqing Wang
,
Qiongya Zhao
,
Miaomiao Du
,
Hongwei Sun
,
Jinjing Wang
,
Jianxin Lyu
,
Hezhi Fang
,
Liqin Jin
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1038/s41389-020-0231-2
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1038/s41389-020-0231-2
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer type with poor prognosis due to its high metastatic potential, however, the role of metabolic reprogramming in the metastasis of PDAC cell is not known. Here, we report that COX6B2 drive metastasis but not cancer cell proliferation in PDAC by enhancing oxidative phosphorylation function (OXPHOS). Transcriptome and clinical analyses revealed that cytochrome c oxidase subunit 6B2 (COX6B2) positively associated with metastasis of PDAC cells. Knockdown of COX6B2 in PDAC cells tuned down the assembly of complex IV and downregulated the function of OXPHOS, whereas re-expression of COX6B2 restored the function of OXPHOS and metastatic potential. Mechanistically, COX6B2 upregulated OXPHOS function to active purinergic receptor pathway for the metastasis of PDAC cells. Notably, the metastatic potential in PDAC could be reversely regulated by metformin, a drug was found accelerating the degradation of COX6B2 mRNA in this study. Collectively, our findings indicated that a complex metabolic control mechanism might be involved in achieving the balance of metabolic requirements for both growth and metastasis in PDAC, and regulation of the expression of COX6B2 could potentially encompass one of the targets.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41389-020-0231-2
- https://www.nature.com/articles/s41389-020-0231-2.pdf
- OA Status
- gold
- Cited By
- 55
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3025982311
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3025982311Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41389-020-0231-2Digital Object Identifier
- Title
-
COX6B2 drives metabolic reprogramming toward oxidative phosphorylation to promote metastasis in pancreatic ductal cancer cellsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-05-15Full publication date if available
- Authors
-
Ke Nie, Jin Li, Xujun He, Yuqing Wang, Qiongya Zhao, Miaomiao Du, Hongwei Sun, Jinjing Wang, Jianxin Lyu, Hezhi Fang, Liqin JinList of authors in order
- Landing page
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https://doi.org/10.1038/s41389-020-0231-2Publisher landing page
- PDF URL
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https://www.nature.com/articles/s41389-020-0231-2.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.nature.com/articles/s41389-020-0231-2.pdfDirect OA link when available
- Concepts
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Metastasis, Cancer research, Oxidative phosphorylation, Pancreatic cancer, Biology, Cancer, Cancer cell, Gene knockdown, Internal medicine, Medicine, Apoptosis, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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55Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 7, 2023: 14, 2022: 11, 2021: 10Per-year citation counts (last 5 years)
- References (count)
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42Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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