cpSRP43 Is Both Highly Flexible and Stable: Structural Insights Using a Combined Experimental and Computational Approach Article Swipe
Mitchell Benton
,
Mercede Furr
,
Vivek Govind Kumar
,
Adithya Polasa
,
Feng Gao
,
Colin D. Heyes
,
Thallapuranam Krishnaswamy Suresh Kumar
,
Mahmoud Moradi
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1021/acs.jcim.3c00319
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1021/acs.jcim.3c00319
The novel multidomain protein, cpSRP43, is a unique subunit of the post-translational chloroplast signal recognition particle (cpSRP) targeting pathway in higher plants. The cpSRP pathway is responsible for targeting and insertion of light-harvesting chlorophyll a/b binding proteins (LHCPs) to the thylakoid membrane. Upon emergence into the stroma, LHCPs form a soluble transit complex with the cpSRP heterodimer, which is composed of cpSRP43 and cpSRP54. cpSRP43 is irreplaceable as a chaperone to LHCPs in their translocation to the thylakoid membrane and remarkable in its ability to dissolve aggregates of LHCPs without the need for external energy input. In previous studies, cpSRP43 has demonstrated significant flexibility and interdomain dynamics. In this study, we explore the structural stability and flexibility of cpSRP43 using a combination of computational and experimental techniques and find that this protein is concurrently highly stable and flexible. In addition to microsecond-level unbiased molecular dynamics (MD), biased MD simulations based on system-specific collective variables are used along with biophysical experimentation to explain the basis of the flexibility and stability of cpSRP43, showing that the free and cpSRP54-bound cpSRP43 has substantially different conformations and conformational dynamics.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acs.jcim.3c00319
- https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c00319
- OA Status
- bronze
- References
- 58
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4381162959
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- OpenAlex ID
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https://openalex.org/W4381162959Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acs.jcim.3c00319Digital Object Identifier
- Title
-
cpSRP43 Is Both Highly Flexible and Stable: Structural Insights Using a Combined Experimental and Computational ApproachWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-06-19Full publication date if available
- Authors
-
Mitchell Benton, Mercede Furr, Vivek Govind Kumar, Adithya Polasa, Feng Gao, Colin D. Heyes, Thallapuranam Krishnaswamy Suresh Kumar, Mahmoud MoradiList of authors in order
- Landing page
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https://doi.org/10.1021/acs.jcim.3c00319Publisher landing page
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https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c00319Direct link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://pubs.acs.org/doi/pdf/10.1021/acs.jcim.3c00319Direct OA link when available
- Concepts
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Thylakoid, Molecular dynamics, Biophysics, Flexibility (engineering), Protein subunit, Chemistry, Microsecond, Biological system, Computational biology, Chloroplast, Biology, Biochemistry, Physics, Computational chemistry, Mathematics, Statistics, Astronomy, GeneTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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58Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5071912456, https://openalex.org/A5067922932 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I78715868 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/7 |
| sustainable_development_goals[0].score | 0.8999999761581421 |
| sustainable_development_goals[0].display_name | Affordable and clean energy |
| citation_normalized_percentile.value | 0.25376898 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |